Baskent University Research Articles

The Effect of Weight Cycling on Cardiometabolic Risk Factors in Women

Aim: This study aims to examine weight cycling causes cardiometabolic risks in women. Materials and Methods: This study was carried out on 60 volunteer women between the ages of 25-45 years who applied to Baskent University Hospital Endocrine Department for weight control. Individuals were applied a questionnaire face to face. Some biochemical parameters were taken from the patient files and anthropometric measurements were evaluated by dietitian. The individuals participating in the study were divided into two groups as those who experienced weight cycling (n: 20) and those who did not (n: 40). Results: The mean BMI was 31.6 ± 4.76 kg/m2 in the weight cyclers and 25.4 ± 4.49 kg/m2 in non-cyclers (p<0.05). The mean waist and hip circumference, waist / hip ratio, total body fat percentage and fat mass were higher in the weight cyclers compared to the non-cyclers (p<0.05). The mean total cholesterol level was 202.2 ± 44.05 mg/dL and 178.1 ± 3 3.39 mg/dL, LDL-cholesterol level was 140.0 ± 40.29 mg/dL and 114.1 ± 28.99 mg/dL, triglyceride level was 129.0 ± 39.52 mg/dl and 99.3 ± 38.37 mg/dL in the weight cyclers and non-cyclers groups, respectively (p<0.05). Conclusion: Weight cycling may be considered as a cardiometabolic risk factor.

Optimization of change in epicardial fat thickness for obese patients who lost weight via the bariatric surgery method using central composite and Box-Behnken experimental designs.

BackgroundThe aim of this study was to detect the optimal values for Age, Body Mass Index (BMI) and HOMA-IR of obese patients prior to surgery that results in a maximal decrease of visceral fat mass 6 months after bariatric surgery.MethodIn this study, 33 experimental set-ups were designed. This study was approved by Baskent University Medical and Health Sciences Research Board (Approval number: KA16/281). The study data consisted of 40 obese patients who lost weight through the bariatric surgery between February 2015 and December 2016. The values of BMI, Age and HOMA for the obese patients who lost weight through the bariatric surgery were evaluated in three categories and at three levels; the response variable was determined as the Change in Epicardial Fat Thickness (ΔEFT).ResultsAs a result of CCD analysis, the optimum ΔEFT = 2.571 was determined when Age = 30.52, BMI = 45.30, and HOMA = 34.62. As a result of the BBD analysis, the optimum ΔEFT = 3.756 was determined, when Age = 38.36, BMI = 63.18, and HOMA = 14.95. The optimum ΔEFT was modeled with Contour and Response Surface plots.ConclusionBased on the two surface response models used in our study, the maximal decrease of visceral fat mass as assessed by measuring echography images of epicardial fat thickness can be obtained by bariatric surgery of persons who are between 31 and 38 year old, have a BMI between 45 and 63 kg/m2 and have a HOMA-IR 34 between 15 and 35. Central Composite Design and a Box-Behnken Design of suitable patient data predicted 35 optimal settings of independent variables for the maximal clinical response of an intervention.

PO-1219 Utility of MRI-guided adaptive radiotherapy for pancreatic cancer: Baskent University experience

PO-1219 Utility of MRI-guided adaptive radiotherapy for pancreatic cancer: Baskent University experience

Impact of Religion on Opinions About Organ Donation and Transplantation in University Students From a Single University in Turkey.

The objective of the present report was to analyze the opinions, attitudes, and practices of Baskent University students with regard to the impact of religion on organ donation and transplantation. We sent a web-based, 5-point Likert scale questionnaire (1: strongly disagree; 5: strongly agree) to capture the opinions and attitudes toward organ donation and transplantation after participants attended or did not a panel discussion on these topics. We sent 361 E-mails and received 69 responses, of which 46 students attended the panel discussion. Most of the participants who attended were part of the faculty of medicine. Participants who did not attend were composed of students from other faculties at Baskent University. Religion played less of a role with regard to opinions on organ donation in those who did not attend. Of the attendees, 54.3% strongly agreed to become organ donors, 50% believed in the important role of religion in organ donation, and 54.3% believed that media sources play important roles in shaping public opinion on organ donation. The majority felt comfortable discussing organ donation with family and friends. Although religion has an undeniable effect on the decision-making process, our survey showed that more than half of the participants were willing to become organ donors. Education, through the joint efforts of medical and religious scholars, as well as the media, should contribute to raising awareness on organ donation, thus contributing to increased access to transplantation worldwide.

Evaluation of the uterine cavity and fallopian tubes in one step in patients undergoing assisted reproductive technology treatment: Hysterosalpingofoam sonography (hyfosy) in combination with hysteroscopy

Aim: To report on the utilization of hysterosalpingo-foam sonography (HyFoSy) with hysteroscopic evaluation for selected patients undergoing Assisted Reproductive Technology Treatment (ART), whereby we aimed to assess the effectiveness of HyFoSy before hysteroscopy. Material and Method: This retrospective study included 36 infertile women referred to Baskent University’s Ankara Hospital Infertility Clinic in 2017-2019. HyFoSy was applied with hysteroscopy in one step for patients who had not previously been evaluated for tubal patency or who had to be re-evaluated. Results: Two patients were diagnosed with tubal obstruction by HyFoSy and were treated with hysteroscopic tubal catheterization, and tubal patency was obtained after this procedure. HyFoSy was applied in seven patients (19.49%) because their previous hysterosalpingography (HSG) reports were doubtful. Although previous HSG had shown tubal obstruction in three patients, the standard passage of the foam from the fallopian tubes to the abdominal cavity was observed when HyFoSy was applied. Conclusion: The one-step method that we apply in our clinic seems appropriate for both patients and clinicians because it speeds up the evaluation steps of the uterine cavity and fallopian tubes before the next ART attempt.

The role of body temperature on respiratory rate in children with acute respiratory infections.

The World Health Organization (WHO) recommends the use of tachypnea as a proxy to the diagnosis of pneumonia. The purpose of this study was to examine the relationship between body temperature alterations and respiratory rate (RR) difference (RRD) in children with acute respiratory infections(ARI). This cross-sectional study included 297 children with age 2-60 months who presented with cough and fever at the pediatric emergency and outpatient clinics in the Department of Pediatrics, Baskent University Hospital, from January 2016 through June 2018. Each parent completed a structured questionnaire to collect background data. Weight and height were taken. Body temperature, respiratory rate, presence of the chest indrawing, rales, wheezing and laryngeal stridor were also recorded. RRD was defined as the differences in RR at admission and after 3 days of treatment. Both respiratory rate and RRD were moderately correlated with body temperature (r=0.71, p<0.001 and r=0.65, p<0.001; respectively). For every 1°C increase in temperature, RRD increased by 5.7/minutes in overall, 7.2/minute in the patients under 12 months of age, 6.4/minute in the female. The relationship between body temperature and RRD wasn't statistically significant in patients with rhonchi, chest indrawing, and low oxygen saturation. Respiratory rate should be evaluated according to the degree of body temperature in children with ARI. However, the interaction between body temperature and respiratory rate could not be observed in cases with rhonchi and severe pneumonia.

Dydrogesterone primed luteal phase stimulation may be better than follicular phase stimulation in patients with diminished ovarian reserve

Objective In this study, we aimed to compare the efficacy of luteal phase stimulation (LPS) and follicular phase stimulation (FPS) in two separate menstrual cycles (2–5 months intervals) of the same patient, utilizing LPS with dydrogesteron only. Methods This retrospective case control study was conducted with patients with diminished ovarian reserve (DOR) (Group 1) and infertile patients with Anti-Müllerian hormone >1.2 ng/mL (Group 2) undergoing two ovarian stimulations (FPS and LPS with dydrogesteron only) and two oocyte retrievals in two separate menstrual cycles (2–5 months intervals) in the Division of Reproductive Endocrinology and Infertility of Baskent University, Ankara, between April 2019 and December 2019. Results In group 1, the number of frozen embryos was significantly higher in LPS when compared to FPS; 1.71 vs. 0.54, (p < .001), respectively. In group 2, the number of frozen embryos was higher in LPS when compared to FPS (0.8 vs. 0.4) however the difference did not reach a statistical significance (p: 0.157). Conclusion LPS may be beneficial especially in the patients with diminished ovarian reserve with follicular asynchronization in the menstrual onset. In addition, it should be kept in mind that dydrogesterone only may be used instead of gonadotropin-releasing hormone antagonist to prevent possible luteinizing hormone rise in LPS.

A model for acute kidney injury in severe burn patients

IntroductionIn patients with severe burns, morbidity and mortality are high. One factor related to poor prognosis is acute kidney injury. According to the AKIN criteria, acute kidney injury has 3 stages based on urine output, serum creatinine level, and renal replacement therapy. In this study, we aimed to create a decision tree for estimating risk of acute kidney injury in patients with severe burn injuries. MethodsWe retrospectively evaluated 437 adult patients with ≥20% total burn surface area injury who were treated at the Baskent University Ankara and Konya Burn Centers from January 2000 to March 2020. Patients who had high-voltage burn and previous history of kidney disease were excluded. Patient demographics, medical history, mechanism of injury, presence of inhalation injury, depth of burn, laboratory values, presence of oliguria, need for renal replacement therapy, central venous pressure, and prognosis were evaluated. These data were used in a “decision tree method” to create the Baskent University model to estimate risk of acute kidney injury in severe burn patients. ResultsOur model provided an accuracy of 71.09% for risk estimation. Of 172 patients, 78 (45%) had different degrees of acute kidney injury, with 26 of these (15.1%) receiving renal replacement therapy. Our model showed that total burn surface area was the most important factor for estimation of acute kidney injury occurrence. Other important factors included serum creatinine value, burn injury severity score, hemoglobin value, neutrophil-to-lymphocyte ratio, and platelet count. ConclusionThe Baskent University model for acute kidney injury may be helpful to determine risk of acute kidney injury in burn patients. This determination would allow appropriate treatment to be given to high-risk patients in the early period, reducing the incidence of acute kidney injury.

EVALUATION OF GRAPHIC DESIGN PROJECT COURSES THROUGH FACE TO FACE EDUCATION AND DISTANCE LEARNING

Tüm dünyada yaşanan salgın hastalık süreci eğitim sistemini de etkilemiştir. Bu çalışmada, Başkent Üniversitesi, Güzel Sanatlar Tasarım ve Mimarlık Fakültesi, Görsel Sanatlar ve Tasarım Bölümü, Grafik Tasarımı Programı 2019-2020 Akademik Yılı Güz Dönemi’nde yüz yüze gerçekleştirilmiş GRA427 Grafik Tasarım proje V dersi ile 2019-2020 Akademik Yılı Bahar Dönemi’nde bu dersin devamı olan çevrimiçi gerçekleştirilmiş GRA428 Grafik Tasarım Proje VI derslerinde tasarlanan projelerin iki farklı eğitim sürecinde karşılaştırmaları yapılıp, yüz yüze ve uzaktan eğitim süreçlerinin grafik tasarım alanındaki etkilerinin araştırılması hedeflenmektedir. Araştırmada, nicel araştırma yöntemlerinden ilişkisel tarama modeli kullanılmıştır. Araştırma grubunu yüz yüze yürütülen Proje V ve uzaktan eğitim ile gerçekleştirilen Proje VI dersine devam eden 20 öğrenci oluşturmuştur. Araştırma sonucunda, yüz yüze eğitimin öğrencilerin sosyalleşmesi ve motivasyonunda daha etkili olduğu, proje üretme aşamasında ders öğretim elemanının anlık yönlendirmelerinin daha güçlü hissedildiği, uzaktan eğitimde ise devam edilemeyen derslerin canlı ders kayıtları ile izlenebilme imkânın olduğu, çevrimiçi dönem sonu ders sergilerinin yoğun izleyici kitlesine sunulabildiği olumlu noktalar olarak ortaya çıkmış; yüz yüze proje dersinde derse gelemeyen öğrencilerin aynı dersi izleme olanağının olmadığı, zaman kullanımı ve maddi harcamanın daha fazla olduğu, uzaktan eğitimde ise sosyalleşme ve motivasyonun daha zayıf olduğu, öğrenci konsantrasyonunun da daha kısa sürede dağıldığı sonuçları ortaya çıkmıştır.

Pediatrik Anestezi Alanındaki Yayınların Bibliyometrik Analizi ve Türkiye Kaynaklı Yayınların Bu Alana Katkısı

Objective: Bibliometric analysis can be used to assess the contributions of scholars, institutions, countries by examining the materials published in a certain discipline. The objective of this study is to make a bibliometric analysis in the field of pediatric anesthesia and to examine Turkey’s contribution to research in this field. Methods: I used the search engine of the Web of Science (WoS), and included all types of contributions (original articles, reviews, letters, editorials, etc.) in the bibliometric analysis. I scanned Science Citation Index Expanded (SCIE) and Emerging Sources Citation Index (ESCI) as they were the most relevant indexes for my study. Statistical analyses were performed by using SPSS 22. I used a binomial test to make a comparison between Turkey and other countries in terms of research output, and academic performance. Results: Pediatric Anesthesia is the only journal that positions itself in WoS categories of both “pediatrics” and “anesthesia”. A total of 5,791 citations were found in this particular journal of which 227 were from Turkey. In addition to this journal, 2,096 published materials were found in 433 different sources. Turkish authors have made only 61 contributions to these journals. Hacettepe University, Istanbul University, and Baskent University are the predominant institutions from Turkey accounting for a total of 80 published materials. Conclusion: The findings of this bibliometric analysis not only showed the contribution of Turkish authors to the field of pediatric anesthesia but also revealed the areas of improvement for their future research. The study also showed a list of journals that publish articles in the area of pediatric anesthesia.

Is percutaneous cholecystostomy bridge to cholecystectomy or definite therapy in high-risk patients with severe acute calculous cholecystitis?

Aim: The medical records of 68 patients diagnosed with severe ACC and treated with PC at Baskent University Faculty of Medicine, General Surgery Clinic between January 2011 and January 2018 were retrospectively analyzed.Results: Among patients who underwent PC for severe ACC at our clinic, 39 (57.4%) were male. Their mean age was 71.7 (28-94) years. All patients had pain; 13 (19.1%) patients had nausea-vomiting; 8 (11.8%) had had fever. The mean time from symptom onset to hospital admission was 6.2 (1-30) days; the mean time from admission to PC placement was 2.1 (1-9) days. Twelve (17.6%) patients had minor complications due to cholecystostomy catheter. Twenty seven (39.7%) patients underwent cholecystectomy with a mean of 83.1 (20-705) days after cholecystostomy placement. Seventeen of these patients underwent laparoscopic surgery and 3 of them converted to open surgery. In 5 of 41 patients who did not undergo cholecystectomy, AC recurrence developed (12.2%) and PC was inserted again. Five (7.4%) patients died.Conclusion: Percutaneous cholecystostomy catheter is an effective treatment to control inflammation until cholecystectomy among high-risk patients diagnosed with severe cholecystitis and may be a definitive therapy for patients unable to undergo surgery.

Factors influencing vaccination status against influenza and pneumococcus in sickle cell anemia patients

Aim: The aim of the present study is to investigate the factors which influence vaccination status against seasonal influenza and pneumococcus in patients with sickle cell anemia which is known to be the most common hereditary hematologic disease worldwide.Materials and Methods: This prospective, cross-sectional study was conducted with the volunteer patients above 18 years who were admitted to Hematology Clinic of Baskent University Adana Research and Training Center due to sickle cell anemia during 01 December – 31 December 2018.Results: Of 38 patients, 22 (57.9%) were females. Ratio of vaccination against pneumococcus was found to be higher among the patients who had vaccination cards (p0.05). Ratio of vaccination against pneumococcus and influenza was found to be higher among the patients who were coming for regular controls and the difference was statistically significant (p0.05). The reason for not getting vaccinated was detected to be “forgetting vaccination” (37.5%), “not believing the necessity of vaccination” (25%) and “not being recommended by health authorities” (25%).Conclusion: It was concluded that vaccination rates could be increased through using vaccination cards, inviting the patients for regular controls and health authorities’ recommending vaccination.

Clinical characteristics and outcomes of ocular injuries in pediatric patients.

Childhood eye injuries are one of the most common causes of acquired unilateral blindness. In this study, our purpose was to investigate the demographics, etiology, and outcome of pediatric patients with ocular injury. The charts of children with ocular trauma who presented to Baskent University Hospitals, between January 1, 2017 and December 31, 2019 were retrospectively reviewed. All patients who were under 16 years of age were included. Data were collected on age, sex, time of trauma, injury type, associated injuries, treatments, visual impairment, intraocular pressure (IOP), and ophthalmic sequelae. Ocular traumas were classified according to the Birmingham Eye Trauma Terminology (BETT) system. A total of 21 patients were identified. Male-female ratio was 13/8. The mean age of the patients was 8.5±3.4 years. Mean post-treatment follow-up was 8.2±4.3 months. Injury was unilateral in all cases (10 right eye, 11 left eye). Fifteen patients (71.4%) had open globe, and 6 (28.5%) had closed globe injury. Type of injury was rupture in 7 cases, perforation in 5, penetration in 4, and intraocular foreign body in 4. A total of 5 cases were documented to have retinal detachment during the follow-up. Sharp injuries were documented in 11 (64.7%) cases, and blunt in 6 (35.2%). The most frequent finding was hyphema in blunt injury, and corneal laceration in perforating injury. Five patients had choroidal hemorrhage, 3 had commotio retinae, 2 had intravitreal hemorrhage, 1 had subhyaloidal hemorrhage, 1 had macular hole, and 1 had optic nerve avulsion. Lens aspiration was performed in 12 (57.1%) cases, and 2 of them had intraocular lens implantation. In children whose initial vision was able to be taken, 4 had no light perception, 7 had light perception-counting fingers, and 5 had best-corrected visual acuity of 0.05-0.3. At final visit, 61.9% of patients had a VA of 0.05-0.8. Corneal scar or leucoma was observed in 14 (66.6%) cases at last visit. One eye was enucleated due to post-traumatic endophthalmitis that did not respond to treatment. At final visit, IOP <6 mmHg was identified in 2 cases and >21 mmHg in 4. Anterior segment damage is the main cause of visual morbidity in pediatric ocular trauma. Injuries with sharp objects occur twice as often as blunt trauma and reduce vision with residual corneal scarring in about two-thirds of patients. Under-standing the pattern of eye injuries is useful in determining the strategies required to protect children's eye health.

LE FORT I OSTEOTOMİSİNDE İKİ PLAK İLE MAKSİLLER FİKSASYON YÖNTEMİ :TEKNİK RAPOR VE VAKA SUNUMU

Restoring facial esthetics and occlusion while maintaining long term stability are the goals of orthognathic surgery. Le Fort I osteotomy is frequently used for the correction of dentofacial deformities and is accepted as a relatively stable procedure. Many factors affecting the stability of the mobilized maxilla have been reported. Among these, the use of a stable internal fixation method is of primary importance to postoperative stability. Most oral and maxillofacial surgeons prefer bilaterally applying titanium miniplates in both the anterior apertura piriformis region and the posterior zygomaticomaxillary buttress region to achieve the rigid fixation of the maxillary segment following Le Fort I osteotomy. In the literature, there is currently a lack of agreement on the number of plates required to adequately secure the mobilized maxilla to prevent postoperative relapse. Reducing the number of miniplates allows surgeons to reduce any potential complications, operation time, and costs. In this case report, a patient with maxillary retrognathia and mandibular prognathia, manifesting dental Class III characteristics who underwent one piece Le Fort I osteotomy at Baskent University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery was presented. Under general anesthesia one piece Le Fort I osteotomy was performed. Following down fracture, mobilization of the maxillary segment was completed and 10 mm horizontal advancement movement was achieved. Surgical rigid fixation was performed under intermaxillary fixation with surgical splints. Maxillary fixation was completed with two pre-bent titanium Le Fort I plate placed bilaterally at the piriform apertura with no zygomaticomaxillary buttress fixation. Prior to extubation, intermaxillary fixation and surgical splints were released. Intermaxillary elastics were used six to eight weeks following surgery in addition to a soft, no-chew diet. The patient received both preoperative and postoperative orthodontic treatment. Digital lateral cephalometric radiographs, which were taken one week before orthognatic surgery (T1), one week postoperatively (T2), and nine months postoperatively (T3), were used to analyze skeletal movement and stability of the maxilla. Lateral cephalometric measurements were performed digitally using a computer-assisted software program. Linear and angular measurements of sagittal and vertical maxillary positions was calculated. A horizontal reference plane (HR) +7° to the SN plane at the S point and a vertical reference plane (VR) 90° to the horizontal plane at the Sella point were used in the analyses. After completion of growth and development, the SN plane remains in the same position, giving us the opportunity to measure skeletal movement with these horizontal and vertical reference planes. The difference in the A point-HR distances between the pre and postoperative radiographs indicates the horizontal movement of the maxilla, whereas the difference in the A point-VR distances indicates the vertical movement of the maxilla. The major criteria for maxillary skeletal relapse was the change in the distance from the A point to the horizontal and vertical reference planes. Significant immediate postsurgical changes were found in early postoperative lateral cephalometric radiography (T2). In 9 month follow-up lateral cephalometric measurements (T3) all landmarks in the horizontal and vertical plane showed skeletal stability. The relapse amount in maxillary movement was less than 1 mm in both horizontal and vertical planes. According to the postoperative lateral cephalometric measurements, the two plate anterior fixation method in the one piece Le Fort I ostetomy showed satisfactory results in terms of skeletal stability.

Yaşlılarda yaşam kalitesi ve yaşlılık algısı: Başkent Üniversitesi örneği

Aging is a continuous and universal process that is seen in every living thing without privilege and causes a decrease in all our functions. In the past 40-50 years, the most important concept that has developed with the increase of the elderly population in the world, especially in developed countries, is the aging of societies. Quality oflife (QOL) was defined by the World Health Organization Quality of Life (WHOQOL) Group as “individuals’ perception of their position in life in the context of culture and value systems in which they live, and in relation to their goals, expectations, standards and concerns” In this study, it was aimed to evaluate the quality of life perception and aging perception of elderly patients who applied to family medicine outpatient clinics of a university hospital. The data of this descriptive and cross-sectional study, the questionnaire containing socio-demographic information, and the Turkish version of WHO’s Quality of Life Instrument Older Adults Module (WHOQOL-OLD)-TR and WHO’s Europe Attitudes to Aging questionnaire. (EAAQ)-TR were created. The questionnaires were applied to Baskent University Hospital Family Medicine outpatient clinics and 200 randomly selected volunteers over the age of 65.All scale dimension scores were compared according to demographic characteristics by statistical t-test and variance analysis. As a result, significant positive correlations among the dimensions of QOL and aging attitude (AA) were obtained. Also total scores of QOL and AA were significantly correlated.Moreover QOL dimension scores were significantly correlated to AA dimension scores. Whereas age and gender were significantly related to psychosocial loss dimension, education was significantly related to psychosocial growth, physical change and total aging attitude scores. Additionally higher educated subjects (university degree) had higher mean scores. The presence of a disease was significantly related to physical change and total aging attitude scores. (p&lt; 0.005) Changes in living environments were significantly correlated to physical change dimension. There is a significant positive correlation between WHOQOL-OLD-TR total scores and AYTA-TR total scores. Increasing the quality of life of the rapidly increasing elderly population will be one of the most important goals in the field of health both today and in the future. Family physicians can provide a better primary health care service by evaluating the quality of life and aging perceptions of the elderly and contribute to the development of new policies in this difficult issue.

Distribution of pathologic smear results and histopathologic agreement in precancerous cervical lesions

OBJECTIVES: The accuracy of the Papanicolau smear test is very important in cervical cancer which is preventable cancer. In this study, we aimed to investigate the distribution of smear results and cyto-histopathological correlation and agreement in biopsies.STUDY DESIGN: A retrospective study was performed at the gynecology obstetrics and pathology department of Baskent University Konya Application and Research Hospital, over a 5-year period. The histopathology results of 89 patients who underwent colposcopic biopsy from 273 patients with pathologic Pap smear results were examined. The histopathologic results and pathologic Pap smear results were compared and the compatibility between them was examined.RESULTS: Data records were collected for 11,191 women. Overall, the prevalence of cytologic abnormalities was 2.43%. The cytohistopathologic correlation in epithelial lesions was 56% and was statistically significant. In glandular lesions, normal biopsy results were reported in 93% of AGC-NOS cytology results, whereas there was a 100% malignancy correlation with AGC-FN cytology results. In terms of detecting low and high-grade lesions, the false-negative rate was 12% and the false-positive rate was 17%.CONCLUSION: In conclusion, Pap smears can be less cost-effective and easily accessible method. While conservative treatment is appropriate in young patients because of possible regression even in high-grade lesions; in older patients, it should not be hesitated to get biopsy when a suspicious clinic is present.

Risk factors for sexual dysfunction in pregnant women during the COVID-19 pandemic.

ObjectiveTo evaluate the level of sexual function during the COVID‐19 pandemic in pregnant women followed up in Baskent University Faculty of Medicine, Turkey, using the Female Sexual Function Index (FSFI).MethodsAn observational analysis was performed on pregnant women who were not infected with COVID‐19. A total of 135 pregnant women (group 1), 45 of whom were in the first trimester, 45 in the second trimester, and 45 in the third trimester, and 45 healthy women who were not pregnant (group 2), were included in the study. The FSFI was used to assess sexual dysfunction status.ResultsA total of 118 (87.4%) pregnant participants and 31 (68.9%) non‐pregnant participants were diagnosed as having sexual dysfunction according to the FSFI. When comparing groups 1 and 2, FSFI scores were significantly lower in group 1 (p = 0.002). It was also found that women who had university degrees, were multiparous, and in the third trimester were more likely to develop sexual dysfunction (p = 0.030, p = 0.029, and p = 0.001, respectively). FSFI scores were found to be significantly higher in planned pregnancies than in unplanned pregnancies (p = 0.001).ConclusionThe sexual function of uninfected pregnant women decreased during the COVID‐19 pandemic, negatively influenced by restrictive social distancing measures.

AİLELERİN FLORÜRLÜ AĞIZ BAKIM ÜRÜNLERİNE BAKIŞ AÇILARININ VE DAVRANIŞLARININ DEĞERLENDİRİLMESİ

ÖZET Amaç: Bu çalışmanın amacı 6-12 yaş grubu çocukları olan ailelerin florürlü ağız bakım ürünlerine bakış açısını, davranışlarını, tutum ve bilgi düzeylerini değerlendirmektir. Gereç Yöntem: Başkent Üniversitesi İstanbul Sağlık Uygulama ve Araştırma Merkezi ve Sultan Abdülhamid Han Eğitim ve Araştırma Hastanesi’ne başvuran 6-10 yaş grubu çocukların ve ailelerin katıldığı çok merkezli prospektif çalışmada toplam 10 soruluk anket uygulandı. Aynı zamanda çocukların ağız diş muayenesi yapıldı ve dft, DMFT indeksi belirlendi. İstatistiksel analizde bağımsız gruplarda t testi, Mann-Whitney U testi, ikiden fazla grup arası karşılaştırmalarında tek yönlü varyans analizi, Bonferroni düzeltmeli ikili değerlendirmeler ve Spearman Korelasyon analizi kullanıldı. İstatistiksel anlamlılık p<0.05 olarak kabul edildi. Bulgular: Bu çalışmaya %44,9’u (n=166) kız çocuk, %55,1’i (n=204) erkek çocuk olmak üzere toplam 370 çocuk ve aile katıldı. . Ailelerin %41.1’i (n=152) florür kullanımı hakkında bilgisinin olmadığını, %52.4’ü (n=194) florür kullanımının çürük oluşumunu engellediği şeklinde bilgisinin olduğunu, %6.51’i (n=24) ise florür kullanımının zeka ve gelişim geriliği yarattığı şeklinde bildiğini belirtti. Florür ile ilgili bilgilerin %35.1’inin (n=130) internetten, %10.0’unun (n=37) çocuk doktorundan, %35.4’ünün (n=131) diş hekimininden, %19.5’i (n=72) komşudan öğrenildiği görüldü. Çocukların dft, DMFT değerleri sırasıyla ortalama 5.50±3.20, 0.62±1.22’dir. Gelir düzeyi 2000 TL’den düşük olan ailelerde florür hakkında bilgisi olmayanların yüzdesinin hem 2000 TL-5000 TL arası hem de 5000 TL’den fazla geliri olan ailelerden istatistiksel olarak anlamlı düzeyde daha yüksek olduğu saptandı (p<0.001, p<0.001). Ailelerin gelir düzeyine göre uygulayıcı ile ilgili tercihlerine, ailelerin bilgiyi aldıkları yere, son altı ayda florür tedavisi yaptırmasına, okul taramasında çocuğa florür verniği yaptırmasına ve çürük sayısına ilişkin dağılımlar bakımından istatistiksel olarak anlamlı farklılık olmadığı bulundu (p>0.05). Ailelerin eğitim durumlarına göre ailelerin florür hakkındaki bilgilerine, uygulayıcı ile ilgili tercihlerine, bilgiyi aldıklara yere göre istatistiksel olarak anlamlı farklılıklar görüldü (p<0.001). Sonuç: Bu çalışmadan elde edilen sonuçlara göre ailelerin florür uygulamaları hakkında yeterli bilgiye sahip olmadıkları ve florürlü ürünlerin kullanımına uzak durdukları görülmüştür. Ailelerin olumsuz tutum ve davranışlarını değiştirerek erken çocukluk çağı çürüklerinin önlenebilir bir hastalık olduğunu, nedenlerini ve florür uygulamalarının koruyucu rolü hakkında bilgilendirmek için daha fazla çaba göstermek hedeflenmeleridir. Anahtar Kelimeler: Ailelerin bakış açısı, florür kullanımı, ağız sağlığı EVALUATION OF PERSPECTIVES AND ATTITUDES OF PATIENTS TOWARDS ORAL CARE PRODUCTS WITH FLUORIDE SUMMARY Aim: The aim of this study was to evaluate the perspectives, behaviors, attitudes and knowledge levels of parents with 6-12 age group children towards oral care products with fluoride. Materials and Method: A total of 10-question questionnaire was completed in a multicenter prospective study of 6-10 year old children and parents who attented Baskent University Istanbul Research and Training Hospital and Sultan Abdülhamid Han Research and Training Hospital. At the same time, children had oral examination and dft, DMFT index was determined. In statistical analysis, independent samples t-test, Mann-Whitney U-test, one-way ANOVA, Bonferroni-Correlated Binary Evaluations and Spearman’s Correlation analyis were used to evaluate the relationships between quantitative variables. Statistical significance was accepted as p <0.05. Results: This study was carried out with the participation of 370 children and parents, 44.9% (n = 166) female children, 55.1% (n = 204) male children. 41.1% (n = 152) of the parents reported that they had no knowledge of the use of fluoride, 52.4% (n = 194) reported that they had knowledge the use of fluoride prevents caries formation; 6.51% (n = 24) reported that they believe that use of fluoride causes intelligence and developmental retardation. 35.1% (n = 130) pointed internet as a source of the information about fluoride, 10.0% (n = 37) pointed pediatrician, 35.4% (n = 131) pointed dentist, 19.5% (n = 72) pointed to the neighbor. The mean dft and DMFT values ​​of the children were 5.50 ± 3.20 and 0.62 ± 1.22, respectively. The percentage of parents who had no knowledge about fluoride was found to be statistically higher in low income (<2000TL) families than higher income families with 2000 TL-5000 TL and families with more than 5000 TL (p <0.001, p <0.001). It was found that there was no statistically significant difference between families according to their income preferences and source of information, fluoride treatment in the last six months, distribution of fluoride to the child in school screening, and distribution of caries (p> 0.05). According to the educational status of the parents, there were statistically significant differences between the families’ knowledge about fluoride, the preferences of the practitioner and the place where they received the information (p <0.001). Conclusions: According to the results of this study, it is seen that families do not have enough knowledge about fluoride applications and they avoided the use of fluoride products. By changing the negative attitudes and behaviors of families, it is aimed to make more effort to inform about the causes and the protective role of fluoride applications in early childhood caries. Keywords: parents’ perspectives, fluoride consumption, oral health

Nulliparity and postmenopausal status are independent factors of malignancy potential of endometrial intraepithelial neoplasia in polyps.

To estimate the risk of concurrent endometrial cancer in endometrium when endometrial intraepithelial neoplasia (EIN) is found within an endometrial polyp and to identify the possible predictive factors for concurrent endometrial cancer. Histopathologic data of women who underwent hysteroscopy for resection of endometrial polyps at Ankara Baskent University Hospital, between 2011 and 2019 were screened. Patients whose polypectomy report was EIN in a polyp, and who had a final report of the hysterectomy specimen were included. Patients were divided into two groups according to the presence of concurrent cancer in the hysterectomy material: group 1, concurrent cancer present and group 2, concurrent cancer absent. Statistical analyses were performed using SPSS. A total of 4125 women underwent hysteroscopy for the resection of endometrial polyps. Of those women, 161 (3.9%) were diagnosed as having EIN and 115 met the criteria. The rate of concurrent endometrial cancer was 28.6% (33/115). According to multivariate analysis, nulliparity (odds ratio [OR] 0.38; 95% confidence interval [CI] 1.04-3.67; p=0.036) and postmenopausal status (OR 0.64; 95% CI 0.42-0.98; p=0.042) were found to be independent factors significantly associated with concurrent endometrial cancer. The incidence of concurrent cancer is higher in postmenopausal or nulliparous women when EIN is detected in a polyp.

Liver transplantation at Baskent University

Liver transplantation at Baskent University