The purpose of present study was to analyze the determination factors that affects the Multicultural Family Support Center in Korea. Data were from the A Study on the National Survey of Multicultural Families 2012. Subjects were 281,606 persons (56,273 male; 225,333 female) over the age of 19 in South Korea. A prediction model was developed by the use of a Radial Basis Function Neural Network Algorithm. In the Prediction model, age, residence, national origin, relationship with spouse parent satisfaction, marital satisfaction relationship between brothers and sisters, nationality status, occupation were significantly associated with experience of Multicultural Family Support Center in South Korea. Received (March 06, 2015), Review Request(March 09, 2015), Review Result(March 27, 2015) Accepted(April 17, 2015), Published(June 30, 2015) 506-706 Dept. Speech Language Pathology & Audiology, Nambu University, Chumdan 23, Gwansangu, Gwangju, Korea email: byeon@nambu.ac.kr (Corresponding Author) 506-706 Dept. Physical Therapy, Nambu University, Chumdan 23, Gwansangu, Gwangju, Korea email: geriatricpt1@naver.com Determination Factors of Multicultural Family Support Center Using Radial Basis Function Neural Network Copyright c 2015 HSST 110