The Usangu basin is a rift basin developed along the Eastern arm of the East African rift system trending in the NE-SW direction. Although the general structures of the basin have been well studied, the structural configuration of the basin and the spatial and depth variations of sediment thickness are still not well known. This study investigates the structures in relation to basement configuration and the variation of sediment thickness within the basin using the Shuttle Radar Topography Mission (SRTM) Digital Elevation Model (DEM), aeromagnetic and gravity data. Results from DEM data indicate a few lineaments on the basin flanks representing the Usangu and Chimala border faults with no structures in the central part of the basin. The aeromagnetic and gravity data highlight three sets of normal and strike-slip faults, most of which trend NE-SW and others NNE-SSW, while a few trend WNW-ESE or NW-SE. Structures on the southwest of the basin reveal complex patterns attributed to the concentration of important tectonic and seismic activities in the study area. The Euler deconvolution and gravity models used to calculate the depth to the basement show that the basement is shallow in the north and south to southwest, and the basin deepens in the northeastern, northwestern and western parts. The findings also reveal that the basin has two grabens, troughs, depression and intrabasinal basement trending in the same direction as the basin configuration. The general thickness of sediments filling the basin ranges from 3 to 4.5 km, with the maximum accumulation of sediments reaching up to 4.8 km in the two depocenters at the south and southwest of the basin. The depth range of the sediments obtained implies that the basin has potential for hydrocarbon exploration with the possibility of natural gas occurrence.