Basic Requirements Research Articles

Assesment of adherence to therapeutic recommendations among patients with hypertension

Abstract Hypertension is a multifactorial condition involving environmental and genetic factors along with risk behaviors. Data from the National Health Fund show that nearly 10 million adult Poles have hypertension. The main goal of drug therapy is to effectively lower blood pressure to normal or near-normal values, and the basic prerequisite for effective pharmacotherapy of chronic diseases is patient adherence to pharmacological recommendations. Objectives The aim of this study was to determine the level of adherence to treatment recommendations among patients with hypertension with regard to sociodemographic and medical variables. Methods This survey-based study included 200 patients with hypertension, hospitalized in the Department of Cardiology with the Intensive Cardiac Care Unit of an Independent Public Clinical Hospital. The author’s questionnaire and The Adherence to Refills and Medication Scale (ARMS) were used as research instruments. Results The study demonstrated the effect of age and place of residence on adherence to treatment recommendations (the older the age, the worse the adherence). The overall level of non-adherence to recommendations (ARMS total score), and the level of non-adherence to taking medications or refilling prescriptions were significantly higher in patients with than without diabetes, and in patients without heart failure than in those with this condition. Conclusion Adherence among patients diagnosed with hypertension was at a good level. Age, employment status, place of residence, and diagnosed diseases (diabetes, heart failure) significantly affected adherence to treatment among the subjects.Table1

Methodology for shielding design and evaluation for container scanners.

There has been an increase in the use of high energy photon beam for container scanners in many countries for multi purposes such as detecting high atomic number materials which might be nuclear materials, drugs, high explosive materials and other contrabands etc. High energy photon beams generally 6 and 9 MV can be used for scanning such materials. However, it is important to ensure that radiation level beyond the container scanner installation is within the permissible dose limit specified by the national competent authority for the protection of public and radiation workers. In this paper, challenges in the biological shielding during the installation of high energy X-ray system for scanning vehicles containing suspected materials are discussed. The purpose of the present study is to develop a methodology for shielding design and evaluation for container scanner installations. The basic concept pertaining to shielding evaluation of radiotherapy installations provided in National Council on Radiation Protection and Measurements (NCRP)/International Atomic Energy Agency (IAEA) reports are referred, and appropriately used to calculate optimized shielding thicknesses requirements for container scanner installation. Workload is estimated based on number of containers scanned, machine ON time and dose rate at 1m. The shielding evaluation includes use of beam stopper in the primary beam, scattering by heterogeneous metallic scrap materials or any other suspected materials contained in the vehicle and their impact on the thickness of shielding walls. A model lay out plan to be used for installation of container scanner is developed. A methodology for shielding evaluation for various protective walls and ceiling of this model is also discussed. The study provides basic requirement for designing a structural room for installing 9MV container scanner from radiological safety view point.

Study on the Design Parameters of Landscape Elements of Urban Tunnel Body Segments in China Based on Biomass Perception

To provide a comprehensive analysis of how an intricate landscape environment comprising various landscape elements influences driving safety and comfort. Beginning with the individual design of the tunnel body section, which includes the roof, sidewalls, road surface, and sidewalk facade markings, this paper references the driver’s biomass index to identify design alterations that satisfy basic safety requirements through simulated driving experiments. Subsequently, employing orthogonal experimental design and semi-supervised clustering algorithms, we ascertain the optimal combination of the four main landscape elements of the tunnel body section that align with both safety and comfort objectives. The experimental findings demonstrate that a safe and comfortable landscape design for urban tunnel sections does not entail a single optimal design; rather, any landscape design conforming to the criterion of “patterned landscapes are set on the side walls and roofs of the tunnel instead of the surface of the road” is the optimal design.

Strong s-box construction approach based on Josephus problem

There are two basic requirements for symmetric encryption algorithms. The first of these is diffusion. The second and most important is confusion. In these algorithms, this requirement is usually met by s-box structures. Therefore, s-box structures must be strong. So, a cryptographically good s-box will make the encryption algorithm difficult to crack. However, obtaining a strong s-box is a rather difficult problem. In this study, Josephus circle logic is used to solve this problem. Initially, with a random s-box structure, the elements are replaced according to their Josephus positions, and the s-box is made stronger. In the proposed algorithm, according to the Josephus logic, the elements that kill each other are replaced and this process continues until one element remains. The last 30 surviving elements are replaced with all elements. In this way, three different s-boxes were obtained. In two of them, the nonlinearity value was 110.5, and in one of them, the nonlinearity value was 110.75. Fixed points in the proposed s-box structures were identified and eliminated. In addition, it has been proven because of the analysis that the obtained s-box structures also meet other cryptographic requirements. In addition to leaving behind most studies in the literature, the proposed method will also provide strong s-box structures for encryption algorithms to be built in the future.

Folic acid capping Bi3+-doped Ag quantum dots for enzyme-like dual-mode recognition of toxic S2− and visual sensing of NO2−

BackgroundNO2− and S2− are two kinds of common toxic anions widely distributed in environmental water, soil and food products. Human beings have suffered a lot of diseases from intake of excessive NO2− or S2−, i.e., infantile methemoglobin, cancer and even to death. Although tremendous efforts have been afforded to monitor NO2− and S2−, most were high instrument-depended with complex processing procedures. To keep food safety and to protect human health, it will be a huge challenge to develop a convenient and efficient way to monitor S2− and NO2− in practice. ResultsA kind of folic acid capping Bi3+-doped Ag quantum dots (FA@Bi3+-Ag QDs) was developed for the first time by one-pot homogeneous reduced self-assembly. Not only did FA@Bi3+-Ag QDs possess intrinsic fluorescent property, it expressed synergistic peroxidase-like activity to catalyze the redox of 3,3′,5,5′-tetramethylbenzidine (TMB) and H2O2 with Km/vmax of 0.087 mM/6.61 × 10−8 M s−1 and 6.42 mM/6.25 × 10−7 M s−1 respectively. Interestingly, trace S2− could exclusively alter its fluorescent property and peroxidase-like activity, exhibiting significant hypochromic and “turn-on” fluorescent effects. While trace NO2− could make FA@Bi3+-Ag QDs-TMB-H2O2 system hyperchromic. Under the optimized conditions, FA@Bi3+-Ag QDs were applied for dual-mode recognition of S2− and visual sensing of NO2− in real food samples with satisfactory recoveries, i.e., 100.7–107.9 %/95.8–104.7 % and 97.2–104.8 % respectively. The synergistic enzyme-mimic mechanism of FA@Bi3+-Ag QDs and its selective response mechanisms to S2− and NO2− were also proposed. SignificanceThis represents the first nanozyme-based FA@Bi3+-Ag QDs system for dual-mode recognition of S2− and visual sensing of NO2−, well meeting the basic requirement in drinking water set by WHO. It will offer a promising way for multi-mode monitoring of different pollution using the same nanozyme-based sensor.

Digital Twin-Enhanced Control for Fuel Cell and Lithium-Ion Battery Hybrid Vehicles

With the development of lithium-ion batteries and fuel cells, the application of hybrid power systems is becoming more and more widespread. To better optimize the energy management problem of fuel cell hybrid systems, the accuracy of system modeling and simulation is very important. The hybrid system is formed by connecting the battery to the fuel cell through an active topology. Digital twin technology is applicable to the mapping of physical entities to each other with high interactivity and fast optimization iterations. In this paper, a relevant model based on mathematical logic is established by collecting actual operational data; subsequently, the accuracy of the model is verified by combining relevant operating conditions and simulating the model. Subsequently, a three-dimensional visualization model of a hybrid power system-based sightseeing vehicle and its operating environment was established using digital twin technology to improve the model simulation of the fuel cell hybrid power system. At low speeds, the simulation results of the hybrid power system-based sightseeing vehicle have a small error compared with the actual running state, and the accuracy of the data related to each internal subcomponent is high. In the simple interaction between the model display vehicle and the environment, the communication state can meet the basic requirements of the digital twin model because the amount of data to be transferred is small. This study makes a preliminary attempt at digital parallelism by combining mathematical logic with visualization models and can be used as a basis for the subsequent development of more mature digital twin models.

استخدام وسيلة السلم والثعبان في تعليم المفردات ﺑSD Islam Qur’ani (البحث التجريبي)

Reading was an important language skill that students learned in learning the Arabic language, and teaching reading related to teaching vocabulary. Learning vocabulary is a basic requirement for learning a foreign language. After the researcher learns that the method and means used in SD Islam Qur’ani are traditional and were not effective in conducting vocabulary teaching, with evidence after observation, the researcher arrived at the results that the students are unable to understand the meaning of vocabulary. It leads to a weakness in the students ability to learn the Arabic language, so the researcher conducted research on the topic “Using the Snakes and Ladders Method in Teaching Vocabulary in SD Islam Qur’ani” "To determine the effectiveness of using the snakes and ladders method in the process of teaching vocabulary. To achieve the intended goal, the researcher designed an experimental research for this research, and the population for this research was all the students of the fourth semester, numbering 45 students. So the researcher took as a sample the research the fourth semester (2) as the experimental group, numbering 22 students. As for The method used to collect data was the method of testing and direct observation, and the researcher obtained the result of the research, which is that the use of the snakes and ladders method is effective in the process of teaching vocabulary in SD Islam Qur’ani. The evidence for this is that the result of the arithmetic t-test is greater than the table t-test result That means 2.09>13.81

Analysis of efficiency and influencing factors of knowledge services in public libraries: the evidence from China

PurposeThe purpose of this study is to quantify and evaluate the efficiency of knowledge services public libraries (PLKS) in China and to analyze the factors affecting the efficiency of PLKS. The focus of this study is to explore the characteristics and changing trends of PLKS and how to improve the efficiency of PLKS. The conclusions drawn in this paper are expected to provide important references for academic research and practical exploration in related fields.Design/methodology/approachThis study constructs a three-stage process of PLKS. On this basis, the efficiency is analyzed by using the Super-NSBM model, and the influencing factors of PLKS are analyzed by using OLS. Finally, through the comprehensive interpretation of the measured data and the existing social development conditions, the authors put forward relevant recommendations.FindingsIn the first stage, the PLKS in China meets the basic requirements, but there is an obvious waste of resources in the second stage. In addition, China’s public libraries show obvious regional differences in knowledge service efficiency. Finally, it was found that economic and technological factors can increase the efficiency of PLKS, but the increase in the number of university students will reduce the efficiency of PLKS.Originality/valueIn this study, the authors provide an exhaustive deconstruction and explanation of PLKS, which leads to the proposal of a three-stage PLKS efficiency conversion process. Furthermore, the authors identify a diverse set of quantifiable metrics that are readily accessible for open collection. Notably, the authors correlated the efficiency of PLKS with the influencing factors, exploring PLKS from a new perspective and enriching the research related to PLKS.

Sex differences in physical functioning among older adults: cross-sectional results from the OUTDOOR ACTIVE study

BackgroundMaintaining good functional ability is a key component of healthy ageing and a basic requirement for carrying out activities of daily living, staying independent, and delaying admission to a nursing home. Even though women have a higher life expectancy and slower age-related muscle mass loss than men, they often show a higher prevalence of limitations in physical functioning. However, the reasons behind these sex differences are still unclear. Therefore, the aims of this study were to investigate sex differences among older adults regarding physical functioning and to study which factors are explaining these sex differences.MethodsCross-sectional data from participants of the OUTDOOR ACTIVE study residing in Bremen, Germany, aged 65 to 75 years, were included in the analyses. Physical functioning was assessed via a self-administered questionnaire using the SF-36 10-item Physical Functioning Scale. Social, lifestyle, and health-related factors were also assessed using the questionnaire. Physical activity was measured objectively using wrist-worn accelerometers over seven consecutive days. Descriptive analyses with absolute and relative frequencies, means and standard deviations, as well as T-tests and chi-square tests were carried out. To test for associations between sex, physical functioning, and several individual factors, linear regressions were performed.ResultsData of 2 141 participants (52.1% female) were included in the study. Women and men showed statistically significant differences in physical functioning, with men perceiving fewer limitations than women. On average, women had a physical functioning score of 81.4 ± 19.3 and men 86.7 ± 17.0. Linear regression showed a statistically significant negative association between physical functioning score and sex (β: -0.15, 95% CL: -0.19, -0.10). The association remained statistically significant when adding individual factors to the model. All factors together were only able to explain 51% of the physical functioning-sex association with health indicators and the presence of chronic diseases being the most influential factors.ConclusionsWe found sex differences in physical functioning, with older women having more limitations than older men. The results showed that health-related factors and chronic diseases played the biggest roles in the different physical functioning scores of women and men. These findings contribute to future longitudinal, more in-depth research.Trial registrationGerman Clinical Trials Register DRKS00015117 (Date of registration 17-07-2018).

Toxin-Induced Animal Models of Parkinson's Disease.

The debilitating motor symptoms of Parkinson's disease (PD) result primarily from the degenerative nigrostriatal dopaminergic pathway. To elucidate pathogenic mechanisms and evaluate therapeutic strategies for PD, numerous animal models have been developed. Understanding the strengths and limitations of these models can significantly impact the choice of model, experimental design, and data interpretation. Herein, we systematically review the literature over the past decade. Some models no longer serve the purpose of PD models. The primary objectives of this review are: First, to assist new investigators in navigating through available animal models and making appropriate selections based on the objective of the study. Emphasis will be placed on common toxin-induced murine models. And second, to provide an overview of basic technical requirements for assessing the nigrostriatal pathway's pathology, structure, and function.

Design and simulation of system to prevent runway overrun during landing of civil aircraft

Abstract The airborne runway overrun prevention system predicts landing distance by utilizing real-time aircraft status parameters obtained through onboard sensors. This system offers early warnings to pilots, thereby enhancing flight safety. This paper introduces a design scheme for a runway overrun prevention system considering aircraft dynamic performance. Initially, the study analyzes the basic components and functional requirements of the system based on the Minimum Operational Performance Standard For A Runway Overrun Awareness And Alerting System by the European Aviation Safety Agency. Subsequently, the approach and landing phases are segmented into four stages, providing a methodology for calculating landing distance using a dynamic model. Finally, concluded with a simulation verification conducted on the X-Plane flight simulation platform, we test the visual alarm system of the proposed runway overrun prevention system. Simulation results demonstrate that, during the landing phase, the system dynamically calculates and updates stopping points for each braking mode based on the current braking method. In situations where there is a risk of runway overrun, the system issues timely and well-founded alarms.

Research on digital entertainment media in English writing e-learning system based on interactive game learning method

As a new teaching tool, digital entertainment media has the potential to improve students’ learning effect and interest. This study aims to explore the application of digital entertainment media based on interactive game learning methods in English writing e-learning system, so as to improve students’ English writing ability and learning enthusiasm. By designing a digital entertainment media e-learning system based on interactive game learning method, this paper studies and designs an intuitive and easy to use interface, so that students can easily browse and participate in interactive game learning activities. Design various types of game tasks and challenges based on interactive game learning methods. Combined with the basic content and requirements of English writing teaching, a variety of interactive learning tools and activities are provided to stimulate students’ learning interest and writing ability. After the implementation of the digital entertainment media e-learning system, students demonstrated a more positive learning attitude and a higher level of English writing by participating in various activities and training provided by the interactive game learning method. They have made significant improvements in writing expression, grammar use and creative thinking.

3D volume construction methodology for cold spray additive manufacturing

Cold spraying has proved as an attractive and rapidly developing solid-state material deposition process that allows for fast formation of high quality, large 3D volume objects. Low risks of undesirable heat effects lead to increased interest in cold spraying based rapid additive manufacturing. However, by continuous powder spraying and high-pressure gas operation, cold spray additive manufacturing in terms of shape building is sensitive to operating parameters and imposes high requirements on the control of process conditions and locally needed kinematics. Every step of the manufacturing process therefore needs to be meticulously conceived and planned, especially the toolpath planning and implementation. This is not only essential to meet basic performance requirements, but also needed for the desired geometric accuracy. To address these needs, this study presents a new implementation method for cold spray additive manufacturing to improve manufacturing accuracy and flexibility. The workflow and principles of the proposed method are explained and strategies are presented for building up various component types, including rotational geometries as well as freestanding parts. The developed algorithms for 3D applications can be well integrated into the cold spray additive manufacturing process for toolpath planning and path parameter determination. Reliable and accurate robot programs were developed to make the process easy to repeat and to follow. Toolpath planning and robot programming are supported and performed by applying virtual cells to simulate the automation process for the real scenario. Path parameter adjustment and kinematic optimization can then be conducted according to the feedback from the simulation result. Applied benchmarking tests prove acceptable shape accuracy and demonstrate that the current method can enhance the capabilities of cold spray additive manufacturing for near-net shape construction. This implies that careful planning and manufacturing strategies should enable overcoming the challenges associated with cold spray additive manufacturing.

Technology Focus: Unconventional and Tight Reservoirs (July 2024)

Unconventional reservoirs bear a unique perplexity in that, at every scale, they are different from their conventional counterparts and even one another. Small nuances in any one parameter can result in a vastly different well result, which may affect how an area, or even an entire play, is interpreted. This month’s selection of papers is all about those differences, in recognition that it is technology that drives innovation through understanding what these differences mean and how best to extract value from these vast resources. Starting at the well scale and looking at the benefits of knowing the efficacy of each stimulation stage, paper URTeC 3864145 is from the Ordos Basin in China. Investigating hydraulic fracture performance on a stage-by-stage basis proves time and time again that understanding the details can improve overall development outcomes. The case study reviews two hydraulic fracture diagnostic techniques used in combination to determine water breakthrough and shutoff plans. Zooming out to the play scale, paper SPE 216292 is focused on the most variable of unconventional reservoirs: the carbonate reservoir. This case study of the Austin Chalk formation in Texas analyses the production uplift from application of horizontal, multistage fracture stimulation technology in tight or fractured carbonate reservoirs. The application of unconventional technology in carbonate reservoirs can extended field life, and the deployment of this technology should be considered for any redevelopment or reassessment of potential resources trapped in tight carbonate reservoirs. Finally, paper OTC 34832 draws on the concept of innovation that is required to unlock unconventional resources. Novel methods of stimulation are the cornerstone of unconventional technology in that well stimulation is a basic requirement of all low-permeability reservoirs. The paper describes a trial pilot from idea through execution from Kuwait Oil Company for enhanced oil recovery in tight formations using downhole hydrogen generation from in-situ exothermic multistage chemical reactions between two unique hydroreacting agents. The paper also provides lessons learned and optimization insights from the trial, concluding that a successful, low-cost alternative stimulation technique was demonstrated and repeatable. Recommended additional reading at OnePetro: www.onepetro.org. SPE 216139 Tight Gas Reservoir Characterization and Comparison of PLT Methods: Microseismic Monitoring, Fiber-Optical Production Logging, and Tracer-Coated Sand Monitoring Applied in the Same Well by Xiao Yao, Petrochina, et al. SPE 216149 New Insight in Developing Tight Fractured Carbonate Reservoirs, Mishrif Formation, West Kuwait by M. El-Jeaan, Kuwait Oil Company, et al. SPE 215712 Successful Utilization of In-Situ Dune Sands in Saudi Arabian Unconventional Frac Operations by Nahar Qahtani, Saudi Aramco, et al.

Quiet quitting: Obedience a minima as a form of nursing resistance.

In this article, we provide a philosophical and ethical reflection about quiet quitting as a tool of political resistance for nurses. Quiet quitting is a trend that gained traction on TikTok in July 2022 and emerged as a method of resistance among employees facing increasing demands from their workplaces at the detriment of their personal lives. It is characterised by employees refraining from exceeding the basic requirements outlined in their job descriptions. To understand why quiet quitting can be a tool of resistance useful for nurses, we first draw on Frédéric Gros' concept of 'surplus obedience' and Michael Lipsky's notion of 'routines and simplification strategies' to highlight the ethical implications associated with nurses engaging in and sustaining harmful systems, such as the neoliberal healthcare system. Leaning again on Gros, we then propose that 'obedience a minima', a concept akin to quiet quitting, can serve as a method of ethical nursing resistance. After describing what the concept entails, we provide a discussion emphasising the potential of obedience a minima as a one method, among many, that can be leveraged by nurses to challenge and resist a system that prioritises financial considerations over patient wellbeing. The article concludes by reflecting on the ethical nature of resistance in the context of nursing, that is the act of obeying oneself and refraining from participating in systems that are detrimental to the lives of Others.

Privacy between Past and Present in Designing Jordanian Homes

This research aims to focus on the role that the interior designer plays in enhancing home efficiency directly and effectively that can be observed through the privacy of homes. The privacy of the interior design is completely affected, whereas the design of each home differs from the other according to the differences that follow individuals' behavior within Residential environments, or even the differences between the daily activities that they practice within their places of residence. The question in the research study is to mainly consider the role that privacy plays in interior design, influencing the composition and characteristics of Jordanian housing and how to design its internal environment between the past and present period, serving the requirements of the daily life of individuals and achieving their satisfaction with their homes. This research follows the deductive inductive and the comparative analytical method to write results. Results confirmed the importance and influence of privacy aspects in the interior design process, as it is a basic requirement that must be considered by the interior designer when carrying out the design process for any housing, where privacy is one of the important aspects and factors that effect on how people deal with their homes in which they live. The results also confirmed that the multiplicity of colors in the design of homes provides better privacy, and that the diverse furniture in the Jordanian homes ensures functional efficiency, which in turn ensures the achievement of privacy for individuals, and that appropriate lighting plays a major role in supporting the privacy of the home, and that the appropriate materials achieve privacy in components of the interior space of interiors, and finally, the well-thought-out spatial planning ensures the high privacy of individuals inside the home. Keywords: Privacy, Interior design, Jordanian housing

Anti-Mainstream Culinary: The Influence of Post-Modernism on Gastronomy in Indonesian Restaurants

The culinary movement is currently undergoing interesting developments: initially, food was a basic requirement for energy and the food consumed was usually processed from nature. Consequently, processed food often characterized the identity of specific tribes, cultures, and regions. In the modern era, food has a long history (for example, the French Revolution), with ethics and rules. This shows that modern food culture is structured and even classifies social classes. Originally, food in the modern era had a concept adapted from the serving of food in palaces, with order and layout. However, this modern presentation of food was rejected by cooks who served food in different ways. For example, enjoying meals at a high altitude and serving food with unusual artistry. With this resistance to the European-style presentation of many luxury restaurants in Indonesia, this post-modernist restaurant can attract customers. This research uses a descriptive qualitative approach. Data collection technique is conducted through visual observation via social media. The findings reveal that the flow of post-modernism and post-structuralism has influenced the way food is served in several Indonesian restaurants. The full results and discussion are presented herein.

Frequency of Zygomatic Complex Fracture in Patients Presenting to Ayub Teaching Hospital

Zygomatic complex fractures are a prevalent type of facial injury. It often results from road traffic accidents (RTA). It poses significant clinical challenges. Objective: To find out the frequency of zygomatic complex fractures among patients introduced at the Ayub Teaching Hospital. Methods: This cross-sectional study was carried out in the Department of Oral and Maxillofacial Surgery at Ayub Teaching Hospital, Abbottabad, Pakistan after approval from IRB (Institutional Review Board) of the Ayub Teaching Hospital Abbottabad, (IRB-F5/Dent/AMC&ATH) from September 1, 2019, to March 1, 2020. A total of 146 patients, including both genders and revealing oral and maxillofacial injury, were essential parts of the research. Before performing meticulous intra and extra-oral clinical examinations and computed tomography (CT) scans in the Department of Radiology to diagnose zygomatic complex fractures. Results: Out of the total number of 146 patients, 33.6% had ZMC fractures. The study involved patients aged 18-60 years. This is consistent with an average age of 31.993 ± 8.00 years and a mean weight of 74.664 ± 9.26 kg. Male patients represented 74.7% of cases and female comprised 25.3%. The primary causes of fractures were road traffic accidents, falls, and sports injuries. Conclusions: The research concluded that zygomatic complex fractures occurred due to road traffic accidents (RTA), which are more common in this region. Thus, the examination highlights the basic requirement for procedures to alleviate street mishaps to abridge such terrible facial injuries.

Determination of Antibiotic Resistance Patterns of Beta-Lactamase-Producing Escherichia coli Strains from Kindirmo in Nasarawa Town, Nasarawa State, Nigeria

Study’s Novelty/Excerpt This study examined the antibiotic resistance patterns of beta-lactamase-producing Escherichia coli in Kindirmo, a traditional fermented milk product, in Nasarawa town, Nasarawa State, Nigeria. It identifies the prevalence of beta-lactamase-producing E. coli in Kindirmo, highlighting a 5.92% contamination rate and revealing complete resistance to six antibiotics among the isolates. The study underscores the public health risks associated with consuming Kindirmo and calls for stringent hygiene measures during its production and sale to protect consumers. Full Abstract This study investigates the antibiotic resistance patterns of beta-lactamase-producing Escherichia coli in Kindirmo in Nasarawa town, Nasarawa State, Nigeria. Over five months, 169 samples were collected from four sampling points. Escherichia coli was isolated using the streak-plating method and identified through biochemical tests. All isolates tested positive for beta-lactamase production. The agar-disc diffusion technique assessed the beta-lactamase-producing E. coli strains' susceptibility to 10 antibiotics. Out of 169 samples, 10 were contaminated with E. coli, resulting in a prevalence of 5.92%. The isolates showed complete resistance to six antibiotics, while 70% and 50% demonstrated susceptibility to ofloxacin, pefloxacin, and gentamicin, respectively. Six antibiotic-resistance phenotypes were identified among the E. coli isolates. The presence of beta-lactamase-producing E. coli in Kindirmo suggests that consuming the product in the area poses a risk to consumers. Authorities should enforce basic hygiene requirements during production and sales to safeguard public health.

ЕВРОПЕЙСКАЯ ИДЕЯ А. БРИАНА В МЕЖВОЕННЫЙ ПЕРИОД

The main purpose of the study is to identify the reasons that hindered the integration processes on the European continent during the interwar period, based on new materials on this topic in the Western press. During the study, the main focus was on establishing the key facts that prevented Aristide Briand's ambitious plans. A. Briand's plan for the creation of the United States of Europe is being considered. The Memorandum of the European Federal Union on the organization of the system of the Federal European Union, the technical aspects of the organization of the System for the Federal Union of Europe, which includes a number of basic prerequisites at the initial stage of the process of building the European Community, are analyzed. On the basis of the Memorandum, proposals are analyzed for future research in the main areas in which the organization could be most attractive, determining its relations with the League of Nations and studying Europe's external relations. The main methods are ideographic, comparative historical and retrospective. The research is carried out in accordance with the principle of historicism and is based on an extensive source base, which is based on recently digitized documents of the League of Nations, selected publications in the press and the works of Western historians.