Basic Index Research Articles

Mining Leachates Effect on the Hydraulic Performance of Geosynthetic Clay Liners under Different Temperatures

Geosynthetic clay liners (GCLs) are often used as anti-seepage systems in landfills and at the bottom of tailing ponds. The anti-seepage performance of GCL will change under different temperatures. In this study, bentonite was mixed with test solutions at different temperatures to measure the basic performance indexes of bentonite components and analyze the permeability. The composition and micro-structure of bentonite at different temperatures were analyzed by X-ray diffraction, X-ray fluorescence spectrum, and SEM, and the change rule of permeability property with the mine leachates at different temperatures was understood by combining the macro-measured parameters with the microscopic analysis results. The research results indicate that the fluid loss of two bentonites increased with the increasing temperature due to the inhibition of ion exchange between bentonite and mixture by the increased temperature. The swelling index of the bentonite increased at high temperatures. The micro-structure analysis showed the increase of the pore size attributed to high temperature, and the uneven distribution of the pore size resulted in the increase of the intrinsic permeability. The study would provide the reference for the application of GCL in mining.

Myelin basic protein and index for neuro-Behçet's disease

Neuro-Behçet's disease (NBD) contributes to poor prognosis in BD patients which lacks reliable laboratory biomarkers in assessing intrathecal injury. This study aimed to determine the diagnostic value of myelin basic protein (MBP), an indicator of central nervous system (CNS) myelin damage, in NBD patients and disease controls. Paired samples of cerebrospinal fluid (CSF) and serum MBP were measured using ELISA, while IgG and Alb were routinely examined before the MBP index was developed. CSF and serum MBP in NBD were significantly higher than in NIND, which could distinguish NBD from NIND with a specificity exceeding 90%, moreover, they could also be excellent discriminators for acute NBD and chronic progressive ones. We found positive linkage between MBP index and IgG index. Serial MBP monitoring confirmed serum MBP's sensitive response to disease recurrences and drug effects, whereas MBP index suggests relapses prior to clinical symptoms. MBP has high diagnostic yield for NBD with demyelination and identifies CNS pathogenic processes before imaging or clinical diagnosis.

Establishment and application of theoretical-empirical prediction model of VMA in hot mix asphalt mixture

Voids in mineral aggregate (VMA) is a basic gradation design index of mineral aggregate in hot mix asphalt (HMA). In order to avoid the tedious process of selecting qualified gradation by obtaining measured VMA values from a large number of experiments, a prediction method of VMA value ranking without testing is established in this paper. Several theoretical-empirical models about VMA corresponding to skeleton porosity, skeleton dense and suspension dense gradations are set up, respectively. According to VMA standard value, measured VCA and the established equation for calculating the passing rate of 2.36 mm or 4.75 mm sieve of skeleton dense gradation, the gradation types of several gradations to be analyzed can be determined, and then the corresponding prediction model maybe selected to predict the VMA value of each gradation. The experimental results based on AC13 (Asphalt concrete with nominal maximum particle size of 13.2 mm) show that the estimated VMA size order is exactly consistent with the measured values, which demonstrates the effectiveness of the prediction method.

The rheological properties of high-viscosity modified reclaimed asphalt binder at multiple application temperatures

The asphalt binder of permeable asphalt concrete has high requirements and there are few studies on mixing reclaimed asphalt (RA) with high-viscosity asphalt (HVA) for recycled permeable asphalt concrete. This study aims to research the wide-temperature-range rheological properties of high-viscosity modified reclaimed asphalt binder (HVRA) which is the bituminous binder in recycled permeable asphalt concrete. First, HVRA was prepared by mixing RA and HVA, wherein RA was extracted from reclaimed asphalt pavement (RAP) and HVA was prepared in the laboratory. Then, the properties of HVRA at multiple application temperatures were analyzed by basic indexes test, dynamic shear rheological test, and bending beam rheometer test. Finally, the comprehensive performance was contrastively evaluated by radar chart. The results revealed that the properties of HVRA are excellent when the high-viscosity modifier (HVM) content is 18 % and 20 %. Additionally, the rheological properties and fatigue resistance of the HVRA showed a decreasing trend with adding RA. Among them, considering rheological properties, the optimal content of HVM in HVA is 18 % − 20 %, and the optimal proportion of RA in HVRA is 10 % − 20 %. Furthermore, the fatigue performance of HVRA is significantly enhanced when HVM content is 18 %, especially the fatigue life of HVRA with 10% RAP is 5–9 times HVA containing 12 % HVM which is regularly used as the bituminous binder.

다문화 청소년의 삶의 만족도 구조모형

The purpose of this study was to construct a hypothetical model based on the life satisfaction of multicultural youths and ecological system theory. In this study, the data of 1,197 high school students who participated in the 8th year of the Multicultural Youth Panel Survey (2018) conducted by the Korea Youth Policy Institute were used for the final analysis. The measurement variables consisted of bi-cultural acceptance attitude, achievement motivation, and family support as exogenous variables, self-esteem and school adaptation as endogenous variables, and life satisfaction as outcome variables. The collected data were analyzed using the SPSS/WIN 23.0 and Amos 21.0 programs. The hypothetical model calculated chi verification, basic fit index, adjusted fit index, double root of approximate error mean square, comparative fit index, standard fit index, and average difference between elements, and the model was found to be suitable. Factors that directly affect life satisfaction of multicultural adolescents were self-esteem, family support, and school adaptation, In addition, self-esteem and school adaptation were found to be important mediating factors between bi-cultural acceptance attitude, achievement motivation, and family support. Therefore various programs should be prepared to improve the life satisfaction of multicultural youths.

COVID-19 Accelerated Cognitive Decline in Elderly Patients with Pre-Existing Dementia Followed up in an Outpatient Memory Care Facility.

Coronavirus disease 2019 (COVID-19) may affect the cognitive function and activities of daily living (ADL) of elderly patients. This study aimed to establish the COVID-19 effect on cognitive decline and the velocity of cognitive function and ADL changes in elderly patients with dementia followed up in an outpatient memory care facility. In total, 111 consecutive patients (age 82 ± 5 years, 32% males) with a baseline visit before infection were divided into those who had or did not have COVID-19. Cognitive decline was defined as a five-point loss of Mini-Mental State Examination (MMSE) score and ADL comprising basic and instrumental ADL indexes (BADL and IADL, respectively). COVID-19 effect on cognitive decline was weighted for confounding variables by the propensity score, whereas the effect on change in the MMSE score and ADL indexes was analyzed using multivariate mixed-effect linear regression. COVID-19 occurred in 31 patients and a cognitive decline in 44. Cognitive decline was about three and a half times more frequent in patients who had COVID-19 (weighted hazard ratio 3.56, 95% confidence interval 1.50-8.59, p = 0.004). The MMSE score lowered on average by 1.7 points/year, independently of COVID-19, but it lowered twice faster in those who had COVID-19 (3.3 vs. 1.7 points/year, respectively, p < 0.050). BADL and IADL indexes lowered on average less than 1 point/year, independently of COVID-19 occurrence. Patients who had COVID-19 had a higher incidence of new institutionalization than those who did not have the disease (45% versus 20%, p = 0.016, respectively). COVID-19 had a significant impact on cognitive decline and accelerated MMSE reduction in elderly patients with dementia.

Analysis of the spatio-temporal coupling coordination mechanism supporting economic resilience and high-quality economic development in the urban agglomeration in the middle reaches of the Yangtze River.

The coupling coordination mechanism between economic resilience and high-quality economic development is clarified not only to improve the capacity of economies to withstand external shocks but also to boost the level of sustainable economic development. However, economic resilience and economic quality research are still in their infancy. This study constructs an economic resilience indicator system based on the data of 28 prefecture-level cities in the urban agglomeration in the middle reaches of the Yangtze River (UAMRYR) from 2010-2019. The entropy approach was then coupled with the coupling coordination model to determine the level of coupling coordination between the two. Finally, the geographical detector was employed to reveal the coupling coordination process and driving elements. This study demonstrates that: (1) The economic resilience and high-quality economic development of the UAMRYR are on the rise; (2) The coupling coordination degree between economic resilience and high-quality economic development is improving, with the average value increasing from 0.33 in 2010 to 0.46 in 2019, exhibiting a Core-Periphery spatial distribution pattern with Wuhan, Changsha, and Nanchang as the core; (3) The economic resilience resistance subsystem plays a substantial role in the driving influence of the coupling coordination degree, where the total retail sales of consumer goods indicator have an explanatory power of 0.8 or higher for coupled coordination. Innovation and inclusiveness thoroughly drive the coupling coordination degree among the five subsystems of high-quality economic development, where the q-value of the number of urban basic endowment insurance participants index is at least 0.9. Additionally, the interplay of the components demonstrates a complementary enhancement impact and a two-factor enhancement effect; (4) Economic resilience and high-quality economic development are complementary and provide a powerful incentive for the sustainable development of urban economic systems to achieve higher quality, more efficient, more egalitarian, and more sustainable economic development. Overall, this study improves the analysis of mechanism between economic resilience and high-quality economic development, and it provides more targeted guidance for economic development in the UARMRYR.

Non-Contact Measurement and Identification Method of Large Flexible Space Structures in Low Characteristic Scenes.

The end-operation accuracy of the satellite-borne robotic arm is closely related to the satellite attitude control accuracy, and the influence of the vibration of the satellite's flexural structure on the satellite attitude control is not negligible. Therefore, a stable and reliable vibration frequency identification method of the satellite flexural structure is needed. Different from the traditional non-contact measurement and identification methods of large flexible space structures based on marker points or edge corner points, the condition of non-marker points relying on texture features can identify more feature points, but there are problems such as low recognition and poor matching of features. Given this, the concept of 'the comprehensive matching parameter' of scenes is proposed to describe the scene characteristics of non-contact optical measurement from the two dimensions of recognition and matching. The basic connotation and evaluation index of the concept are also given in the paper. Guided by this theory, the recognition accuracy and matching uniqueness of features can be improved by means of equivalent spatial transformation and novel relative position relationship descriptor. The above problems in non-contact measurement technology can be solved only through algorithm improvement without adding hardware devices. On this basis, the Eigensystem Realization Algorithm (ERA) method is used to obtain the modal parameters of the large flexible space structure. Finally, the effectiveness and superiority of the proposed method are verified by mathematical simulation and ground testing.

Preparation and performance evaluation of rubber powder-polyurethane composite modified cold patch asphalt and cold patch asphalt mixture

Considering the unfavorable stability and insufficient strength of cold patch mixtures used in pavement pothole repair at an early age, 80 mesh waste rubber powder and polyurethane were selected for composite modification of #70 base asphalt, in which the contents of the two modifiers were determined through parallel tests with basic performance indexes of asphalt being employed as the criteria for evaluation. The modified asphalt was diluted with XSJ-1, a self-made composite diluent, and the preparation process of cold patch asphalt, as well as the cold patch asphalt formula, were defined. Based on DSR, DSC and FTIR tests, the performance of the composite modified cold patch asphalt was evaluated, and the modification mechanism was analyzed. The cohesion, strength, high-temperature stability, and moisture susceptibility of the cold patch asphalt mixture were evaluated with two types of commercially available cold patch asphalt mixtures as the comparison. The outcomes demonstrate that the qualities of waste rubber powder/polyurethane composite modified cold patch asphalt are significantly superior to those of single modified cold patch asphalt. The viscosity of cold patch asphalt is remarkably influenced by the quantity of diluent employed. It is recommended that base asphalt contain 10 % and 7 %, respectively, of waste rubber powder and polyurethane with a diluent of 25 %. The initial strength and formed strength of the composite modified cold patch mixture were considerably higher than those of the control cold patch mixtures, and the time needed to reach the formed strength was shortened by 2 days.

Relationship of liver fat content with systemic metabolism and chronic complications in patients with type 2 diabetes mellitus

ObjectiveThis study investigated the correlation of liver fat content (LFC) with metabolic characteristics and its association with chronic complications in type 2 diabetes mellitus (T2DM) patients.MethodsEighty-one prospectively enrolled T2DM patients were divided into non-alcoholic fatty liver disease (NAFLD) group and the non-NAFLD group according to the presence of NAFL complications. LFC was determined by MRI IDEAL-IQ Sequence, and patients were divided into 4 groups according to LFC by quartile method. Basic information, metabolic indexes, and occurrence of chronic complications in different groups were analyzed and compared.ResultsBMI, SBP, DBP, TG, ALT, AST, GGT, UA, HbA1c, FCP, 2 h CP, HOMA-IR, and HOMA-IS in the NAFLD group were significantly higher than the non-NAFLD group (P < 0.05). The incidences of chronic complications in the NAFLD group were higher than in the non-NAFLD group but not statistically significant (P > 0.05). BMI, SBP, DBP, TC, TG, ALT, AST, FCP, 2 h CP, HOMA-IR, and HOMA-IS showed significant differences between the patients with different LFC, and these indexes were significantly higher in patients with higher LFC than those with lower LFC (P < 0.05). Moreover, diabetes duration, TC, HOMA-IR, and LFC were the risk factors for ASCVD complications, while diabetes duration, TG, and LDL-C were risk factors for DN complications. Also, diabetes duration and SBP were risk factors for both DR and DPN complications in T2DM patients (P < 0.05).ConclusionLFC is positively correlated with the severity of the systemic metabolic disorder and chronic complications in T2DM patients.

Case Study on Pre-Splitting Blasting Reasonable Parameters of Goaf-Side Entry Retained by Roof Cutting for Hard Main Roof

The key parameters of pressure relief pre-splitting blasting technology (PRPBT) contribute to the implementation effect of goaf-side entry by roof cutting (GSERC). This study is an attempt to design the key parameters including the roof cutting height, the roof cutting angle, the spacing between blasting boreholes, the charge structure and the sealing length by using theoretical analysis, numerical simulation and field implementation. The basic quality index of the main roof is 666.27, and combined with the peeping observation result, the main roof belongs to the category of a hard main roof. Different from a weakened roof and a compound roof, the unreasonable parameters of the PRPBT for the hard main roof lead to three problems including an insufficient pre-splitting blasting effect, roof suspension in the goaf and serious damage to the rock mass for the roof cutting rib. The PRPBT effect is closely related to key parameters, including the roof cutting parameters and the pre-splitting blasting parameters. Hence, to solve those three problems, a new design strategy was proposed based on the optimized directions of increasing the roof cutting height, decreasing the spacing between the blasting boreholes, changing the charge structure and adjusting the sealing length. According to the results of the theoretical calculation, numerical simulation and in situ measurement, the roof cutting height, the roof cutting angle, the spaced distance between the blasting boreholes, the charge structure and the sealing length were determined as 10 m, 15°, 500 mm, 4 + 4 + 3 + 3 + 2 and 2.4 m, respectively. The fissure rate was proposed to assess the developed effect of different pre-splitting blasting schemes. The proposed design strategy achieved a better effect of pre-splitting blasting for the entry, and eliminated the roof suspension of the hard main roof in the goaf. The design strategy in this study could contribute to other similar coal mines under the condition of a hard main roof.

The Role of Technology in the Learning Process: A Decision Tree-Based Model Using Machine Learning

Machine learning approaches may establish a complex and non-linear relationship among input and response variables for the assessment of the Basic Education Development Index (IDEB) database and show indicators that may contribute to monitoring the quality of education. This paper uses extensive experimental databases from public schools, consisting of a case study in Brazil, to analyze data such as the physical and technological structure of schools and teacher profiles. The research proposes decision tree-based machine learning models for predictions of the best attributes to positively contribute to IDEB. It employs a newly developed SHapley Additive exPlanations (SHAP) approach to classify input variables, so to identify variables that impact the most the final model; a non-probabilistic sample was used, composed from three official databases of 450 schools, and 617 teachers. Results show that the number of computers per student, teachers’ service time, broadband internet access, investments in technology training for teachers, and computer labs in schools are the variables that have the greatest effect on IDEB. The model applied shows high prediction accuracy for test data (MSE = 0.2094 and R² = 0.8991). This article contributes to improving efficiency when monitoring parameters used to measure the quality of a teaching-learning process. Doi: 10.28991/ESJ-2022-SIED-020 Full Text: PDF

The Role of Technology in the Learning Process: A Decision Tree-Based Model Using Machine Learning

Machine learning approaches may establish a complex and non-linear relationship among input and response variables for the assessment of the Basic Education Development Index (IDEB) database and show indicators that may contribute to monitoring the quality of education. This paper uses extensive experimental databases from public schools, consisting of a case study in Brazil, to analyze data such as the physical and technological structure of schools and teacher profiles. The research proposes decision tree-based machine learning models for predictions of the best attributes to positively contribute to IDEB. It employs a newly developed SHapley Additive exPlanations (SHAP) approach to classify input variables, so to identify variables that impact the most the final model; a non-probabilistic sample was used, composed from three official databases of 450 schools, and 617 teachers. Results show that the number of computers per student, teachers’ service time, broadband internet access, investments in technology training for teachers, and computer labs in schools are the variables that have the greatest effect on IDEB. The model applied shows high prediction accuracy for test data (MSE = 0.2094 and R² = 0.8991). This article contributes to improving efficiency when monitoring parameters used to measure the quality of a teaching-learning process. Doi: 10.28991/ESJ-2022-SIED-020 Full Text: PDF

Effects of prenatal polycyclic aromatic hydrocarbons and childhood material hardship on reading achievement in school-age children: A preliminary study.

Children from socioeconomically disadvantaged backgrounds are at elevated risk for reading problems. They are also likely to live in neighborhoods with high levels of air pollution and to experience material hardship. Despite these risk factors, the links between prenatal chemical exposures, socioeconomic adversities, and reading problems in youth from disadvantaged backgrounds remain understudied. Here we examine associations between prenatal exposure to polycyclic aromatic hydrocarbons (PAH), a common air pollutant, and reading skills, and determine if this relationship is exacerbated by material hardship among Black and/or Latinx children who have been followed as part of a longitudinal urban birth cohort. Mothers and their children, who were participants in a prospective birth cohort followed by the Columbia Center for Children's Environmental Health, were recruited for the current study. Personal prenatal PAH exposure was measured during the third-trimester of pregnancy using a personal air monitoring backpack. Mothers reported their level of material hardship when their child was age 5 and children completed measures of pseudoword and word reading [Woodcock Johnson III Tests of Achievement (WJ-III) Basic Reading Index] at age 7. We used multiple linear regression to examine the effects of the interaction between prenatal PAH and material hardship on Basic Reading Index, controlling for ethnicity/race, sex, birthweight, presence of a smoker in the home (prenatal), and maternal education (prenatal) (N = 53). A prenatal PAH × material hardship interaction significantly associated with WJ-III Basic Reading Index scores at age 7 (β = -0.347, t(44) = -2.197, p = 0.033). Exploratory analyses suggested that this effect was driven by untimed pseudoword decoding (WJ-III Word Attack: β = -0.391, t(44) = -2.550, p = 0.014). Environmental chemical exposures can be particularly toxic during the prenatal period when the fetal brain undergoes rapid development, making it uniquely vulnerable to chemical perturbations. These data highlight the interactive effects of environmental neurotoxicants and unmet basic needs on children's acquisition of reading skill, specifically phonemic processing. Such findings identify potentially modifiable environmental risk factors implicated in reading problems in children from economically disadvantaged backgrounds.

Research Status of Cathode Materials for Lithium Ion Batteries

Thanks to the promotion of new energy vehicles, the industry of lithium-ion batteries has ushered in its booming period. The current industry of lithium ion batteries is in rapid development with great potential. Therefore, many researchers have turned to focus on lithium ion batteries to obtain better lithium ion batteries. In this paper, the literature review of cathode materials for lithium ion batteries is to be carried out from the following aspects, including the overview of lithium ion batteries, their basic performance indexes, and the classification and preparation methods of cathode materials. Besides, the present situation and modification strategies of cathode materials for lithium ion batteries will be further analyzed, so as to improve their electrochemical performance.

Incidence and progression of erosive tooth wear according to tooth type in schoolchildren of Mexico City.

This study aimed to estimate the cumulative incidence and the progression of erosive tooth wear (ETW) according to tooth type over a follow-up period of 18 months in adolescents living in Mexico City. We examined 10,776 teeth from 424 participants and used the Basic Erosive Wear Examination index (BEWE) to assess ETW. Our results showed that the overall cumulative incidence rate of ETW was 5.9% (587 from 9933 teeth), and the progression of ETW was 10% (85 from 843 teeth). Notably, the cumulative incidence of initial texture loss (BEWE = 1) was 29.1% for maxillary central incisors, and 30.4% of mandibular first molars progressed to loss of hard tissues (BEWE ≥2).

Liver tuberculosis in children

Objective. The primary tuberculosis infection in childhood is manifested as a common disease. The diagnostics of liver tuberculosis is still a little-studied problem due to the absence of clinical manifestations.Purpose. To study clinical course, diagnostics and management of liver tuberculosis in children.Material and methods. 5 children, aged from 5 days to 16 years, with liver tuberculosis were under the observation. To put diagnosis, the researchers used the following parameters: anamnesis, examination, laboratory and specific tests, ultrasound, radiological methods including CT, biopsy of the surgical material.Results and discussion. Out of 5 children with liver tuberculosis, 3 had disseminated miliary pulmonary tuberculosis with liver damage; one had liver tuberculosis of the tuberculoma type and one had tumor-like liver tuberculosis. These three observations are described the article. In the diagnostics, basic indexes are CT of the abdominal organs, histological examination of the surgical material and positive Diaskin test.Conclusion. An isolated tuberculous liver damage is a rare case. More often, several anatomical regions are simultaneously involved in the specific process.

A Study on High and Low Temperature Rheological Properties and Oil Corrosion Resistance of Epoxy Resin/SBS Composite Modified Bitumen

In order to investigate the high and low temperature rheological properties and fuel corrosion resistance of epoxy resin on SBS modified asphalt, epoxy resin/SBS composite modified asphalt (ER/SBS) was prepared by high-speed shear. Moreover, composite modified bitumen with different proportions were designed based on the uniform design method and the basic performance index test was performed. The optimal composite mixing ratio of the ER and SBS modifier in composite modified asphalt (2.3% and 3.8%, respectively) was determined. Temperature scanning and a multiple stress creep test (MSCR) on ER/SBS composite modified asphalt with different ER content before and after oil corrosion was carried out using a dynamic shear rheometer (DSR). In addition, the high temperature rheological properties of different ER contents and composite modified asphalt after oil corrosion were evaluated by combing DSR measurements with the test data. The creep stiffness (S) and creep rate (m) indexes were obtained by a bending rheometer (BBR), and the effect of ER on the low-temperature rheological properties of SBS modified bitumen was investigated. The influence of the modifier incorporation on the micromorphology of asphalt and the change of micromorphology of asphalt after oil corrosion were analyzed by fluorescence microscopy. The test results show that the incorporation of 2.3% ER and 3.8% SBS can effectively improve the high temperature performance of SBS modified asphalt under the premise of cost saving. Moreover, the composite modified asphalt doped with ER can effectively improve the resistance of SBS modified asphalt to fuel corrosion at high temperatures, and the greatest improvement in the oil corrosion resistance of composite modified asphalt is observed at the ER content of 2.3%.

Experimental Study on Flexural Properties of Polyurethane–Cement Composites under Temperature Load

Polyurethane cement composite is a new organic–inorganic composite material with high strength, corrosion resistance, and fast curing. It is a complement and alternative to traditional cement materials. The flexural properties of polyurethane cement composites are the basic mechanical index of the material. In order to study the flexural properties under different temperature loads, a molecular model was established, the chemical reaction process of polyurethane cement and the temperature response mechanism was analyzed, and the preparation process of polyurethane cement was proposed. Then, bending tests were carried out in strain-controlled mode to obtain the specimens’ bending strength and stiffness modulus under different temperature loads. The test results showed that the tensile strength of polyurethane cement decreased first, then increased, and finally decreased with the increase in temperature, while the bending stiffness modulus decreased with the increase in temperature. Combined with the theoretical derivation, the damage mode of the samples under different temperature loads was analyzed, and the “L-type” damage strain curve was obtained. The results showed that the proposed theory could effectively explain the mechanism of action and flexural properties of polyurethane cement composites under temperature loading, which is a significant improvement to the application of polyurethane cement composites in practical engineering.

Evaluation of the pharmacological effects and exploration of the mechanism of traditional Chinese medicine preparation Ciwujia tablets in treating insomnia based on ethology, energy metabolism, and urine metabolomic approaches.

Ciwujia Tablets (CWT) are produced by concentrating and drying the extract solution of the dried rhizome of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim [Araliaceae; E. senticosus radix et rhizoma]. Besides, CWT is included in the 2020 edition of Chinese Pharmacopoeia and is widely used in the treatment of insomnia. It mainly contains eleutheroside B, eleutheroside E, isofraxidin, eleutheroside C, ciwujiatone, and chlorogenic acid, as well as other chemical components. Although the clinical efficacy of CWT in treating insomnia has been confirmed, its functions and pharmacological effects have not been systematically evaluated and its mechanism of action in the treatment of insomnia remains unclear. Therefore, in this study, behavioral, energy metabolism, and metabonomics methods were applied to systematically evaluate the effect of CWT on insomnia. Additionally, urine metabonomics based on UPLC-Q-TOF-MS/MS were utilized to identify potential endogenous biomarkers of insomnia, detect the various changes before and after CWT treatment, explore the metabolic pathway and potential target of CWT, and reveal its pharmacological mechanism. Results revealed that CWT increased inhibitory neurotransmitter (5-HT and GABA) content and reduced the content of excitatory neurotransmitters (DA and NE). Moreover, CWT enhanced autonomous behavioral activity, stabilized emotions, and promoted the return of daily basic metabolic indexes of insomniac rats to normal levels. The urine metabolomics experiment identified 28 potential endogenous biomarkers, such as allysine, 7,8-dihydroneopterin, 5-phosphonooxy-L-lysine, and N-acetylserotonin. After CWT treatment, the content of 22 biomarkers returned to normal levels. The representative markers included N-acetylserotonin, serotonin, N-methyltryptamine, and 6-hydroxymelatonin. Additionally, the metabolic pathways in rats were significantly reversed, such as tryptophan metabolism, folate biosynthesis, phenylalanine metabolism, and tyrosine metabolism. Ultimately, it is concluded that CWT regulated tryptophan metabolism, folate biosynthesis, phenylalanine metabolism, and other metabolic levels in the body. This drug has been confirmed to be effective in the treatment of insomnia by regulating the content of serotonin, 6-hydroxymelatonin, N-acetylserotonin, and N-methyltryptamine to a stable and normal level in tryptophan metabolism.