This paper takes the training objective of applied talents under the background of new engineering as the guidance, the concept of OBE as the guidance, the knowledge system and practical ability as the training direction, and the focus of each course of basic chemistry. The investigation was carried out from the five aspects of teaching syllabus, course content, teaching model, application ability and assessment method. It is committed to cultivating a group of high quality composite new engineering talents with strong practical ability, innovation ability and international competitiveness