Basic Cardiovascular Sciences Research Articles

4th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences

4th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences

Developing Strategies to Link Basic Cardiovascular Sciences with Clinical Drug Development: Another Opportunity for Translational Sciences

Driven, at least in part, by the National Institutes of Health roadmap, an increasing number of studies has bridged the chasm between observations in the basic research laboratory and the clinical bedside. These studies have been an integral part in "translating" new discoveries into therapeutic initiatives. However, "translational medicine" has been used less frequently in the development of cardiovascular drugs or in predicting the potential cardiovascular toxicity of non-cardiac agents. Studies in animal models can provide important clues as to the potential cardiotoxicity of new therapeutic agents, as well as providing a template for the rational design of clinical trials. Three examples of drug development programs that might have been altered by clues available from laboratory studies include the development programs for the anti-cancer drug trastuzumab, the cyclooxygenase inhibitors, and the adenosine-receptor agonists and antagonists. Although mouse models may not always represent the physiology of humans, they provide important information that clinical scientists can utilize in designing safe programs for the evaluation of new pharmacologic agents.

Correction

HomeCirculation ResearchVol. 99, No. 11Correction Free AccessCorrectionPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessCorrectionPDF/EPUBCorrection Originally published24 Nov 2006https://doi.org/10.1161/01.RES.0000252902.06789.a0Circulation Research. 2006;99:e87This article corrects the following3rd Annual Symposium of the American Heart Association Council on Basic Cardiovascular SciencesIn the Abstracts from the 3rd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences: Translation of Basic Insights Into Clinical Practice (July 31–August 3, 2006, Keystone Conference Center Keystone, CO), which appeared in the September 1, 2006 issue (Circ Res. 2006;99:E18–e50), the abstract “Prenatal Hypoxia Determines Dilated Cardiomyopathy in the Adult Through a VEGF-Dependent Mechanism” (abstract P64) has been withdrawn by the authors. This has been corrected in the current online version of the abstracts. Previous Back to top Next FiguresReferencesRelatedDetailsRelated articles3rd Annual Symposium of the American Heart Association Council on Basic Cardiovascular SciencesCirculation Research. 2006;99:E18-E50 November 24, 2006Vol 99, Issue 11 Advertisement Article InformationMetrics https://doi.org/10.1161/01.RES.0000252902.06789.a0 Originally publishedNovember 24, 2006 PDF download Advertisement

3rd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences

HomeCirculation ResearchVol. 99, No. 53rd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences Free AccessOtherPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessOtherPDF/EPUB3rd Annual Symposium of the American Heart Association Council on Basic Cardiovascular SciencesTranslation of Basic Insights Into Clinical Practice: July 31–August 3, 2006 Keystone Conference Center Keystone, CO: BCVS Symposium Abstracts Originally published3 Apr 2018https://doi.org/10.1161/res.99.5.E18Circulation Research. 2006;99:E18–E50is corrected byCorrection Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesCorrectionCirculation Research. 2006;99:e87-e87 September 1, 2006Vol 99, Issue 5 Advertisement Article InformationMetrics https://doi.org/10.1161/res.99.5.E18 Originally publishedApril 3, 2018 PDF download Advertisement

Circulation Research Editors’ Annual Report for 2005

The Editors of Circulation Research are pleased to present this annual report on the progress of the journal over the course of 2005, the sixth year of our editorship. The journal saw continued overall growth and success in 2005, with increased submissions and brief time to publication. Submissions to the journal have climbed steadily since 1999. In 2005 Circulation Research reached new heights, receiving the greatest number of submissions in journal history, a total of 1935 articles (Figure 1). Manuscript submissions came from a diverse array of nations, including both developing countries and well-established centers of science (Figure 2). Figure 3 tracks submissions by region for the United States, Europe, Japan, Canada, and other countries. We have seen a slight decline in submissions from the United States from 2004 to 2005, while submissions from Europe and other countries have increased by 3%. The Editors encourage all authors, regardless of country of origin, to look to Circulation Research as the preeminent journal for cardiovascular basic science and mechanistic clinical research. Figure 1. Number of submissions to …

2nd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences

2nd Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences

Circulation Research Editors’ Annual Report for 2004

The Editors of Circulation Research are pleased to produce this annual state-of-the-journal report. Looking back on 2004, our fifth year as stewards of this fine publication, we are happy to relate that this was a year of continued growth and success. The editorial complement has evolved insofar as Marlene Rabinovitch stepped down as Associate Editor after four years of distinguished service to the journal; Kathy Griendling was recruited to fill the void and has become a valued member of the team. Fortuitously, Kathy and Marlene shared the 2004 Basic Research Prize of the American Heart Association. Submissions to Circulation Research have soared during the past five years, with each year setting a new record. Year 2004 was no exception. The journal received 1884 submissions, exceeding the 2003 total by 4% (Figure 1). Manuscript submissions to Circulation Research came from a diverse spectrum of nations, from well-known centers of science to developing countries (Figure 2). Even with this …

Heart Physiology From Cell to Circulation, 4th ed.

Lionel H. Opie, MD 640 pp. Baltimore, Md: Lippincott Williams & Wilkins; 2003. $99.00. ISBN 0-7817-4278-1 Many excellent basic cardiovascular science and clinical cardiology texts are available to help the academic or practicing cardiologist keep abreast of the rapid developments in these areas. Few, however, combine a lucid and up-to-date description of new and established findings in laboratory research with an informed discussion of their clinical relevance to the pathophysiology and treatment of cardiac disease. This new edition of Dr Opie’s highly regarded book does this extremely well, as indicated in the …

First annual symposium of the American Heart Association Council on Basic Cardiovascular Sciences: stress signals, molecular targets, and the genome.

The completed sequence of a human genome, alongside increasingly those of model organisms, in rank of use and tractability, lays before the investigator the raw matter of inherited biology in stark and exquisite reductionist detail. At the dawn of our millennium, this newly arrived state of knowledge—omniscience, with respect to sequence—set into place the concatenation of new questions and bracing opportunities deemed the “postgenomic” era. What genes serve what functions, when, where, and how? (Even the most optimistic among us dispenses with “why?”) At a higher level of complexity, what networks of genes serve what functions, and how are these coordinated? How, too, do proteins relate, not just pairwise but in intricate webs of physical associations, counting in the thousands or many tens of thousands? In other words, broad-band biology. For the cardiovascular sciences, long-separate strands of work converged in recent years, in …

Circulation Research Editors’ Yearly Report: 2003

We are pleased to produce this yearly report on the status of our journal. Simply put, 2003 was a banner year for Circulation Research , which celebrated its 50th anniversary of publishing the best of basic cardiovascular science and translational research for the American Heart Association. The Editors hope you enjoyed over the past year the many personal reminiscences from prominent individuals in the field who reflected on the past 50 years of cardiovascular research and the journal as a vehicle for publication of the science. We are pleased to announce in this, our fourth such state-of-the-journal report, that Circulation Research received a total of 1813 manuscripts in 2003. This sets not only a new record for submissions to the journal, but exceeds our previous record by 21.8% (Figure 1). While submissions increased in the past year, our acceptance rate decreased slightly to a near-record low of 19.7% (Figure 2). The Editors remain committed to maintaining the journal’s traditional standards of selectivity, despite the number of submissions received. Figure 1. Number of submissions to Circulation …

Meetings Calendar

Meetings Calendar

Cardiovascular News

Cardiovascular News

Upcoming therapies for heart failure

Treatment of maladaptive neurohormonal activation in congestive heart failure (CHF) has been successful because basic cardiovascular science findings have been confirmed or dismissed through the use of well-controlled, large-scale clinical trials. It should be no surprise that this exciting approach is evolving toward novel agents and devices directed toward other pathways involved in CHF neurohormonal/ cytokine activation. Several of these are in advanced clinical development and are likely to play prominent roles in CHF therapy in the near future.

Two AHA councils become one. Ringing out the old and bringing in the new.

At the dawning of the new millennium, major changes in cardiovascular science lie on the horizon, including increased pay lines and a proposal to double the National Institutes of Health (NIH) budget in 5 years; major victories in the war against cigarette smoking by the American Heart Association (AHA) and an emphasis on outcomes research; the winding down of the Human Genome project; a reduction in the number of young people entering academic cardiovascular medicine; and the transition to a new editor at Circulation Research . Concurrent with all of these events and, perhaps, to better participate in these new directions, the Councils on Circulation and Basic Science, two of the thirteen councils of the AHA, have recently merged. The merger comes after a great deal of agonizing over the past several years, in fact, for more than 35 years, concerning the now artificial distinction between disciplines in basic cardiovascular sciences and the ensuing loss of individual identity due to the merging of so many scientific disciplines. Out of this reflection comes what we believe to be the best of the “old councils” and new energy and direction from their union. Council (Section) on Circulation: The Council on Circulation1 2 was the first “section” of the AHA and was formed as the Section on Peripheral Circulation in 1935. Its function was to encourage investigation into the function of the circulation. At its first annual meeting in 1936, nine papers were presented on topics such as assessment of peripheral resistance, surgical treatment of hypertension, …