Abstract Background A Multiple Deprivation Index (MDI) is a composite measure designed to comprehensively evaluate the socio-economic status of individuals within a population. While various countries have employed their own versions of MDI to assess deprivation, none have been developed at the European level thus far. The BEST-COST project (www.best-cost.eu) aims to integrate the dimension of social inequalities in the assessment of the burden of environmental stressors, using a new MDI. Therefore, the objective of this study is to conduct a scoping review to identify and assess current MDIs while extracting details on the methodologies employed in their development. Methods We conducted a scoping review on deprivation indices in European countries, encompassing three databases (Medline, Embase and Web of Science). Following screening of all the articles based on inclusion criteria, we specifically examined the methodological choices made across the development of the MDIs, such as the choice of the underlying indicators, geographical scales, data source used, and if and/or how indicator weighting was applied in creating a composite score. Results In total, 22 MDIs were identified from 195 articles. 42% of these indices were developed from census data at the municipality level or finer. About half of them (55%) employed weighting of indicators, thereby reflecting their relative importance within the index’s score. From these 22 MDIs, a total of 156 individual indicators were extracted. These indicators encompass several domains such as basic amenities, crime, education, employment, family structure or income. The extensive variety of indicators can be attributed to cultural differences within the EU, data availability and the specific time period during which each index was developed. Conclusions Several European countries have separately developed their own MDI, showcasing significant variability in both the included individual indicators and the methodologies applied. Key messages • This review highlights the variability of existing indices and which methodologies could be used for the development of a Europe-wide multiple deprivation index. • It further emphasizes the importance of considering cultural differences and data availability across countries in this process.