The strongest earthquake in the Urals registered during the period of instrumental observations, with a magnitude of ML-5.4 occurred in the area of Katav-Ivanovsk city, Chelyabinsk region, on 05.09.2018. In October 2018, Institute of Geophysics, the Ural Branch RAS organized temperature and radon observations. The conducted studies have shown that the behavior patterns of the volume radon activity (VRA) established for the tectonic event preparation in the subduction zone (Southern Kuriles), are also true for the South Ural region. The natural phenomena caused by the earthquake 2018 preparation are analyzed. During the observation period from 28.11.2018 to 23.05.2019, there was an increase in temperature with a gradient of 0.02°C per month. The observed patterns of VRA abnormal behavior before aftershocks in the Katav-Ivanovsk area are typical for the compression zone in the radon monitoring area. It is noted that the assumed compression deformations were manifested in the hydrogeodynamic field at least 10 years before the event proper. The proximity of earthquake foci to the identified aseismic zone within the boundaries of the East European Platform, the Pre-Ural Regional Trough, and the Bashkir anticlinorium indicates the most likely places of seismic events. The arranged temperature and radon monitoring network in the epicentral zone by observing aftershocks has shown the possibility of tracking the earthquake preparation process.