Functional Bases Research Articles

Improving the infrastructure of the stock market in the context of economic modernization

The article describes the economic essence of the stock market infrastructure and the main directions of its formation, the scientific and theoretical basis. The foreign experience of the stock market infrastructure and stock exchanges has been studied, and opportunities for their application to the stock market of Uzbekistan have been identified. Analysis of the institutional, technical and functional bases of the stock market, the economic situation in the stock market of the Republic of Uzbekistan. Factors influencing the development of stock market infrastructure were systematized and analyzes were performed on the autoregressive distributed lag ARDL model based on the factors influencing the stock market infrastructure (UCI) and their complex econometric methods.

Xanthine oxidase inhibitory potentials of flavonoid aglycones of Tribulus terrestris: in vivo, in silico and in vitro studies

BackgroundDespite the ongoing safety-driven spate of flavonoid xanthine oxidase (XOD) inhibition investigations, there is a lack of flavonoid-based uricostatic antihyperuricemic agents in clinical medicine. The poor pharmacokinetic profiles of glycosides (the natural form of existence of most flavonoids) relative to their aglycones could be largely responsible for this paradox. This investigation was aimed at providing both functional and molecular bases for the possible discovery of XOD inhibitory (or uricostatic) anti-hyperuricemic flavonoid aglycones from the leaves of a flavonoid-rich medicinal plant, Tribulus terrestris. To this end, the flavonoid aglycone fraction of T. terrestris leaf extract (FATT) was evaluated in vivo for antihyperuricemic activity in ethanol-induced hyperuricemic mice, monitoring serum and liver uric acid levels. Molecular docking and molecular dynamics simulation studies were carried out on the three major flavonoid aglycones of T. terrestris (isorhamnetin, quercetin and kaempferol) against an inhibitor conformation XOD model. The three flavonoids were also subjected to in vitro XOD activity assay, comparing their IC50 to that of allopurinol, a standard uricostatic antihyperuricemic drug.ResultsFATT significantly lowered serum uric acid (p < 0.0001) and liver uric acid (p < 0.05) levels of the experimental animals, implying anti-hyperuricemic activity with uricostatic action mechanism allusions. Molecular docking studies revealed high binding affinity values (− 7.8, − 8.1, − 8.2 kcal/mol) for the aglycones (isorhamnetin, quercetin and kaempferol, respectively). Radius of gyration and RMSD analyses of the molecular dynamics simulation trajectories of the three aglycone–XOD complexes revealed substantial stability, the highest stability being demonstrated by the kaempferol–XOD complex. In vitro XOD activity assay showed kaempferol (IC50: 8.2 ± 0.9 μg/ml), quercetin (IC50: 20.4 ± 1.3 μg/ml) and isorhamnetin (IC50: 22.2 ± 2.1 μg/ml) to be more potent than allopurinol (IC50: 30.1 ± 3.0 μg/ml).ConclusionThis work provides a scientific basis for the use of T. terrestris in the treatment of hyperuricemia-related (e.g. kidney stone and gout) disorders. It also provides the molecular basis for a focussed screening of the flavonoid aglycones chemical space for the possible discovery of flavonoid-based uricostatic anti-hyperuricemic drugs or drug templates.

ОПТИМІЗАЦІЙНИЙ МЕТОД КОМРЕСІЇ БАГАТОСПЕКТРАЛЬНИХ ЦИФРОВИХ ЗОБРАЖЕНЬ ПРОЕКЦІЙНОЇ ПРИРОДИ

A method for compressing digital images of a projection nature obtained in an arbitrary amount of spectral radiation ranges - a carrier of specific information or under various positional conditions of formation, optimized according to the criteria for preserving the specified levels of signal image energy and their structural similarity, is proposed. The method uses the representation of a set of such images in the form of a single multidimensional geometric object, which is described by a two-dimensional data array ordered by raster and spectral intervals and includes preprocessing by means of singular decomposition of the specified array. Actual compression is carried out by means of decomposition the constituent images, represented by maximum singular numbers, according to discrete orthonormed functional bases, zeroing out part of the decomposition coefficients and subsequent reconstruction of the digital brightness codes of images. The determination of the thresholds for zeroing the decomposition coefficients of images digital levels is formulated in the form of a two-criteria optimization problem of obtaining the given ratios of signal energies of the compressed and initial images and indices of their structural similarity. The implementation of the proposed methods includes the following steps: pairwise orthogonalization of distributions of digital brightness codes of images in different spectral channels based on singular decompositions; preservation of the constituent distributions of brightness with maximum singular numbers; compression of orthogonalized representations according to the specified criteria; reconstructing the brightness codes of compressed images of spectral channels by a functional transformation reversed by the one used at the stage of decomposition of brightness distributions of directly recorded multispectral images. Comparison of various discretized functional bases as the basis for compression showed the greatest efficiency in the specified criteria of the discrete functional basis of Haar. Key words: multispectral image, orthogonalization, signal energy, structural similarity index, orthonormed basis.

Linking quantitative genetics with community-level performance: Are there operational models for plant breeding?

Plant breeding is focused on the genotype and population levels while targeting effects at higher levels of biodiversity, from crop covers to agroecosystems. Making predictions across nested levels of biodiversity is therefore a major challenge for the development of intercropping practices. New prediction tools and concepts are required to design breeding strategies with desirable outcomes at the crop community level. We reviewed theoretical advances in the field of evolutionary ecology to identify potentially operational ways of predicting the effects of artificial selection on community-level performances. We identified three main types of approaches differing in the way they model interspecific indirect genetic effects (IIGEs) at the community level: (1) The community heritability approach estimates the variance for IIGE induced by a focal species at the community level; (2) the joint phenotype approach quantifies genetic constraints between direct genetic effects and IIGE for a set of interacting species; (3) the community-trait genetic gradient approach decomposes the IIGE for a focal species across a multivariate set of its functional traits. We discuss the potential operational capacities of these approaches and stress that each is a special case of a general multitrait and multispecies selection index. Choosing one therefore involves assumptions and goals regarding the breeding target and strategy. Obtaining reliable quantitative, community-level predictions at the genetic level is constrained by the size and complexity of the experimental designs usually required. Breeding strategies should instead be compared using theoretically informed qualitative predictions. The need to estimate genetic covariances between traits measured both within and among species (for IIGE) is another obstacle, as the two are not determined by the exact same biological processes. We suggest future research directions and strategies to overcome these limits. Our synthesis offers an integrative theoretical framework for breeders interested in the genetic improvement of crop communities but also for scientists interested in the genetic bases of plant community functioning.

Genomic Variants Disrupt miRNA-mRNA Regulation.

Micro RNA (miRNA) and its regulatory effect on messenger RNA (mRNA) gene expression are a major focus in cancer research. Disruption in the normal miRNA-mRNA regulation network can result in serious cascading biological repercussions. In this study, we curated miRNA-related variants from major genomic consortiums and thoroughly evaluated how these variants could exert their effects by cross-validating with independent functional knowledge bases. Nearly all known variants (more than 664 million) categorized by type (germline, somatic, epigenetic) were mapped to the genomic regions involved in miRNA-mRNA binding (miRNA seeds and miRNA-mRNA 3'-UTR binding sequence). Subsets of miRNA-related variants supported by additional functional evidence, such as expression Quantitative Trait Loci (eQTL) and Genome-Wide Association Study (GWAS), were identified and scrutinized. Our results show that variants in miRNA seeds can substantially alter the composition of a miRNA's target mRNA set. Various functional analyses converged to reveal a post-transcriptional complex regulatory network where miRNA, eQTL, and RNA-binding protein intertwined to disseminate the impact of genomic variants. These results may potentially explain how certain variants affect disease/trait risks in genome wide association studies.

Multi-functional BST2/tetherin against HIV-1, other viruses and LINE-1.

Bone marrow stromal cell antigen 2 (BST2), also known as CD317, HM1.24, or tetherin, is a type II transmembrane glycoprotein. Its expression is induced by IFN-I, and it initiates host immune responses by directly trapping enveloped HIV-1 particles onto the cell surface. This antagonistic mechanism toward the virus is attributable to the unique structure of BST2. In addition to its antiviral activity, BST2 restricts retrotransposon LINE-1 through a distinct mechanism. As counteractive measures, different viruses use a variety of proteins to neutralize the function or even stability of BST2. Interestingly, BST2 seems to have both a positive and a negative influence on immunomodulation and virus propagation. Here, we review the relationship between the structural and functional bases of BST2 in anti-HIV-1 and suppressing retrotransposon LINE-1 activation and focus on its dual features in immunomodulation and regulating virus propagation.

Gene expression and genetic divergence in oak species highlight adaptive genes to soil water constraints.

Drought and waterlogging impede tree growth and may even lead to tree death. Oaks, an emblematic group of tree species, have evolved a range of adaptations to cope with these constraints. The two most widely distributed European species, pedunculate (PO; Quercus robur L.) and sessile oak (SO; Quercus petraea Matt. Lieb), have overlapping ranges, but their respective distribution are highly constrained by local soil conditions. These contrasting ecological preferences between two closely related and frequently hybridizing species constitute a powerful model to explore the functional bases of the adaptive responses in oak. We exposed oak seedlings to waterlogging and drought, conditions typically encountered by the two species in their respective habitats, and studied changes in gene expression in roots using RNA-seq. We identified genes that change in expression between treatments differentially depending on species. These "species × environment"-responsive genes revealed adaptive molecular strategies involving adventitious and lateral root formation, aerenchyma formation in PO, and osmoregulation and ABA regulation in SO. With this experimental design, we also identified genes with different expression between species independently of water conditions imposed. Surprisingly, this category included genes with functions consistent with a role in intrinsic reproductive barriers. Finally, we compared our findings with those for a genome scan of species divergence and found that the expressional candidate genes included numerous highly differentiated genetic markers between the two species. By combining transcriptomic analysis, gene annotation, pathway analyses, as well as genome scan for genetic differentiation among species, we were able to highlight loci likely involved in adaptation of the two species to their respective ecological niches.

The orbitalauricular chord of Alligator: The unusual functional linkage between the earflap and eyelid of Crocodylians.

One of the distinctive features of the Crocodylia is the presence of a superficial meatal chamber the aperture of which is regulated by two earflaps. The movements of the upper earflap have been detailed by multiple workers, however, the mechanics of the lower earflap remain unresolved. The present study was undertaken to document the mechanics of the lower earflap in the American alligator, Alligator mississippiensis, and to explore the functional bases of coordinated movements between the lower earflap and lower eyelid in this species. This anatomical system was examined using a combination of fresh dissection, histology, and micro-CT analyses applied to post-embryonic specimens. The rostral margin of the lower earflap is tightly bound to a block of dense connective tissue herein termed the orbitalauricular chord. The orbitalauricular chord is anatomically distinct from both a ligament and a tendon. The dorsal surface of the orbitalauricular chord is attached to a slip of the levator palpebra, while the ventral surface is attached to a slip of the depressor palpebra. These attachments produce a simple mechanism for the elevation and depression of the lower earflap, and thus the opening and closing of the meatal aperture. The caudal surface of the orbitalauricular chord has connective tissue links to the rostral margin of the lower earflap. The morphology of the orbitalauricular chord appears to explain both the mechanics of the lower earflap and the functional coupling between the lower eyelid and lower earflap.

Vibration of Complex Euler–Bernoulli and Timoshenko–Ehrenfest Beams Through Affine GPSFs

Abstract Vibrations of thin and thick beams containing internal complexities are analyzed through generalized bases made of global piecewise-smooth functions (GPSFs). Such functional bases allow us to globally analyze multiple domains as if these latter were only one, such that a unified formulation can be used for different mechanical systems. Such bases were initially introduced to model a specific part of stress and displacement components through the thickness of multi-layered plates; subsequent extensions were introduced in the literature to allow the modeling of thin-walled beams and plates. However, in these latter cases, certain analytical difficulties were experienced when inner boundary conditions needed to be englobed into the GPSFs; in this work, such mentioned difficulties are successfully overcome through certain affine transformations which allow the analyses of vibrating complex beam systems through a straightforward analytical procedure. The complex mechanical components under investigation are Euler and/or Timoshenko models containing inner complexities (stepped beams, concentrated mass or stiffness, internal constraints, etc.). The ability of the models herein analyzed is shown through the comparison of the resulting solutions to exact counterparts, if existing, or to finite elements solutions.

For Straight Persons, Correlates of Biphobia Are Mostly the Same as for Homophobia

In a previous study, for a sample of 187 female and 107 male straight U.S. college undergraduates randomly assigned to complete measures of homophobia and transphobia with either born-female or born-male targets, the authors reported on the similarities and differences between the correlates for homophobia versus those for transphobia, dependent on participant and/or target gender. Participants in this study also completed a widely used measure of biphobia. In the present brief report, the authors show not only that straight participants’ homophobia scores were highly correlated with their biphobia ones but that the correlations of homophobia with other predictors were highly similar to the corresponding ones for biphobia. In contrast to the previously demonstrated functional bases for differences in determinants of straight individuals’ attitudes about gay/lesbian versus transgender individuals, these new findings indicate that, for straight individuals, determinants of biphobia largely overlap with those for homophobia.

Investigating the Role of Dahuang in Hepatoma Treatment Using Network Pharmacology, Molecular Docking, and Survival Analysis.

Hepatoma is one of the most common malignant tumors. The incidence rate is high in developing countries, and China has the most significant number of cases. Dahuang is a classic traditional antitumor drug commonly used in China and has also been applied to treat hepatoma. However, the potential mechanism of Dahuang in treating hepatoma is not clear. Therefore, this study is aimed at elucidating the possible molecular mechanism and key targets of Dahuang using methods of network pharmacology, molecular docking, and survival analysis. Firstly, the active ingredients and key targets of Dahuang were analyzed through public databases, and then the drug-ingredient-target-disease network diagram of Dahuang against hepatoma was constructed. Five main active components and five core targets were determined according to the enrichment degree. Enrichment analysis demonstrated that Dahuang treated hepatoma through the multiple pathways in cancer. Additionally, molecular docking predicted that aloe-emodin and PIK3CG depicted the best binding energy. Survival analysis indicated that a high/ESR1 gene expression had a relatively good prognosis for patients with hepatoma (p < 0.05). In conclusion, the current study results demonstrated that Dahuang could treat hepatoma through a variety of active ingredients, targets, and multiantitumor pathways. Moreover, it effectively improved the prognosis of hepatoma patients. ESR1 is the potential key gene that is beneficial for the survival of hepatoma patients. Also, aloe-emodin and beta-sitosterol are the two main active crucial ingredients for hepatoma treatment. The study also provided some functional bases and references for the development of new drugs, target mining, and experimental animal research of hepatoma in the future.

Theoretical Analysis of Scientific Approaches to the Study of Printing of Recreational and Tourist Complexes

Relevance: the relevance, declared in the article of the problem, and the time being discussed, based on theoretical analysis of scientific approaches, their generalization systematized theoretical and methodological bases of functioning of entertainment, and recreational facilities in the national economy, refined the concept of recreation and wellness center. Purpose: The purpose of this research is to develop and improve organizational and economic bases for stimulating the development of the tourist and recreational complex. Methods: Different research methods, including the dialectical approach (the study of institutional units included in the tourist and recreational complex), grouping (the classification of types of tourism and tourist and recreational resources), a systematic approach (structurization touristy) was used to achieve the set goal. Tourist and recreational complex), the method of structural-logical generalization (improvement of the conceptual apparatus for stimulating the development of the tourist-recreational complex), index, comparative Economic and statistical analysis (determination of the state and efficiency of the tourism and recreation complex functioning), project analysis (evaluation of the effectiveness of investment projects), and others. Results: The theoretical and methodological developments in the part of tourist and recreational classification of territories are considered. Based on the worked out sources, a generalization is made that the main problem in the complex assessment of recreational and tourist resources is their delimitation during the assessment. Іdentifies theoretical approaches to the study of the attractiveness of the tourist and recreational complex, substantiates the economic content of this study, as well as reveals the conceptual foundations of the study of the attractiveness of the tourist and recreational complex. Practical Significance: The socio-economic preconditions for the formation of the attractiveness of the tourist and recreational complex have been studied, as well as the attractiveness of the tourist and recreational complex has been assessed. The basis is the scenario of the development of common features for the tourist-recreational and resort systems, namely: the possibility of modelling a variety of economic development options, especially in regions that do not have the main segments of the economy (industry and agriculture) but have resources for tourism and recreation.

The frontostriatal subtype of mild cognitive impairment in Parkinson's disease, but not the posterior cortical one, is associated with specific EEG alterations

BackgroundThe ‘dual syndrome’ hypothesis states that two cognitive subtypes can be distinguished in mild cognitive impairment in Parkinson's disease (PD-MCI): a frontostriatal one, characterized by attentional and/or executive deficits, and a posterior cortical one, characterized by visuospatial, memory and/or language deficits. The latter type has been associated with a higher risk of earlier development of PD dementia. The functional bases of these subtypes remain partly unknown. ObjectiveTo identify EEG modifications associated with PD-MCI subtypes. Methods75 non-demented PD patients underwent a comprehensive neuropsychological assessment and a high-density EEG. They were classified as having normal cognition (PD-NC; n = 37), PD-MCI with a frontostriatal subtype (PD-FS; n = 11) or PD-MCI with a posterior cortical subtype (PD-PC; n = 27). Two EEG analyses were performed: (a) spectral powers quantification and (b) functional connectivity analysis. ResultsPD-FS patients displayed spectral and functional EEG alterations, namely (a) higher powers in the theta and delta bands, (b) lower powers in the beta2 band and (c) lower functional connectivity in the beta2 band compared to PD-NC and PD-PC patients. These alterations were mainly located in the frontal, limbic and parietal regions. There were no significant differences between PD-NC and PD-PC. ConclusionEEG alterations previously reported in PD-MCI may only concern the frontostriatal subtype, and not the posterior-cortical subtype. This provides evidence for the dual syndrome hypothesis and emphasizes the importance of identifying PD-MCI subtypes. It also shows the promising potential of EEG to discriminate between PD-MCI subtypes.

Administrative and legal bases of functioning of the institute of private performers in Ukraine

During the study, the author considers the administrative and legal principles and factors that contributed to the reform of the penitentiary system in Ukraine, analyzes the types of penitentiary systems operating in European countries, the impact of European experience on reforming domestic legislation and bringing it into line with European Union requirements. compliance with the third Copenhagen and Madrid criteria for membership in the European Union through the adaptation of domestic legislation, the establishment of relevant institutions of the legal system of Ukraine acquis communautaire. The special approach of Ukraine during the reform in terms of uneven, special, inherent in Ukraine distribution of powers between private and public performers is outlined. The research of domestic scientists of the institute of private executors and the system of executive proceedings after the reform as a whole is presented. The efficiency of private performers' activity is determined, as well as problematic issues of full-fledged existence of the institute of private performers in Ukraine. The statistical data operated by international experts, as well as the Association of Private Performers of Ukraine are given. A thorough study of the main factors that hinder the proper development of private performers in today's conditions. Ways to improve the institution of private performers, by continuing to reform, improving the legislation governing the selection and further activities of private performers are proposed.

Functional tensor network solving many-body Schrödinger equation

Schr\"odinger equation belongs to the most fundamental differential equations in quantum physics. However, the exact solutions are extremely rare, and many analytical methods are applicable only to the cases with small perturbations or weak correlations. Solving the many-body Schr\"odinger equation in the continuous spaces with the presence of strong correlations is an extremely important and challenging issue. In this work, we propose the functional tensor network (FTN) approach to solve the many-body Schr\"odinger equation. Provided the orthonormal functional bases, we represent the coefficients of the many-body wave-function as tensor network. The observables, such as energy, can be calculated simply by tensor contractions. Simulating the ground state becomes solving a minimization problem defined by the tensor network. An efficient gradient-decent algorithm based on the automatically differentiable tensors is proposed. We here take matrix product state (MPS) as an example, whose complexity scales only linearly with the system size. We apply our approach to solve the ground state of coupled harmonic oscillators, and achieve high accuracy by comparing with the exact solutions. Reliable results are also given with the presence of three-body interactions, where the system cannot be decoupled to isolated oscillators. Our approach is simple and with well-controlled error, superior to the highly-nonlinear neural-network solvers. Our work extends the applications of tensor network from quantum lattice models to the systems in the continuous space. FTN can be used as a general solver of the differential equations with many variables. The MPS exemplified here can be generalized to, e.g., the fermionic tensor networks, to solve the electronic Schr\"odinger equation.

Development of a machine learning-based soft sensor for an oil refinery’s distillation column

In this paper, a machine learning framework based on Kaizen Programming is proposed for building a soft-sensor using real historical data from an oil refinery. The soft-sensor estimates the composition of C4 hydrocarbons in the distillate stream of a splitter column. Kaizen Programming is a novel technique that has shown excellent results for symbolic regression problems without requiring a priori selection of the functional bases. The framework follows three different steps: pre-processing of the data, model building with the selected algorithm, and ensemble of different good-fitting models. The final ensemble model accurately predicts operation of the column at and between two steady states, outperforming the model based on Gaussian Process in both validation and soft-sensor degradation scenarios.

Medicine-Food Herbs against Alzheimer’s Disease: A Review of Their Traditional Functional Features, Substance Basis, Clinical Practices and Mechanisms of Action

Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder that currently has reached epidemic proportions among elderly populations around the world. In China, available traditional Chinese medicines (TCMs) that organically combine functional foods with medicinal values are named “Medicine Food Homology (MFH)”. In this review, we focused on MFH varieties for their traditional functional features, substance bases, clinical uses, and mechanisms of action (MOAs) for AD prevention and treatment. We consider the antiAD active constituents from MFH species, their effects on in vitro/in vivo AD models, and their drug targets and signal pathways by summing up the literature via a systematic electronic search (SciFinder, PubMed, and Web of Science). In this paper, several MFH plant sources are discussed in detail from in vitro/in vivo models and methods, to MOAs. We found that most of the MFH varieties exert neuroprotective effects and ameliorate cognitive impairments by inhibiting neuropathological signs (Aβ-induced toxicity, amyloid precursor protein, and phosphorylated Tau immunoreactivity), including anti-inflammation, antioxidative stress, antiautophagy, and antiapoptosis, etc. Indeed, some MFH substances and their related phytochemicals have a broad spectrum of activities, so they are superior to simple single-target drugs in treating chronic diseases. This review can provide significant guidance for people’s healthy lifestyles and drug development for AD prevention and treatment.

Peculiarities of the state environmental policy of Ukraine through the prism of environmental legislation

The article considers the environmental policy of the state through the analysis of environmental legislation of Ukraine. This legislation is one of the main tools, as well as a priority effective mechanism for implementing state environmental policy. The article analyzes the theoretical approaches and legal support of the peculiarities of the formation and provision of favorable conditions for the implementation of state policy in the field of environmental protection, use of natural resources, environmental safety. Theoretical bases of formation and functioning of ecological policy, the basic tasks and mechanisms of its realization, in particular at the national level are opened. Reforming the system of legal acts aimed at implementing the state environmental policy of Ukraine should take place in all priority areas, in particular, such as climate change prevention, biodiversity conservation, waste management, biological and genetic safety, restoration of the environment of polluted areas. emergencies, create an effective system of access to environmental information, improve air quality, water, land resources; natural resources management.

РОЗВИТОК СИСТЕМИ УПРАВЛІННЯ ПРОМИСЛОВИМИ ВІДХОДАМИ ПРИЧОРНОМОРСЬКОГО РЕГІОНУ В КОНТЕКСТІ ЦИРКУЛЯРНОЇ ЕКОНОМІКИ: ПРОБЛЕМИ ТА ПЕРСПЕКТИВИ

The article proposes an integrated approach to assessing the development of the industrial waste management system of the Black Sea region. This approach is based on the use of a set of indicators that characterize the current state of functioning of this system from an environmental and economic point of view. Based on the obtained results of the conducted diagnostics, barriers, threats, ecological bases of functioning of the regional system of industrial waste management are revealed. As a result of the research it is proved that to ensure the effective functioning of the industrial waste management system of the Black Sea economic region it is advisable to implement an integrated approach, the implementation of which will promote sound innovative decisions in environmental management; timely solution of waste management problems using the principle of systematicity; minimization of negative impact on the environment by reducing the volume of waste generation, increasing the volume of processing and reuse of industrial waste, the transition to a circular economy, expanding the responsibility of producers; increasing the level of environmental security of the region; achieving the goals of sustainable development. In order to improve the management system of industrial waste in the Black Sea region, it is advisable to: introduce the latest technologies and equipment for collection, sorting, transportation, processing and disposal of waste, taking into account best European practices; promoting the use of waste recycling as a secondary raw material on the basis of "green" investment; development of a financial mechanism for the use of public-private partnerships based on attracting private investment and other extra-budgetary sources of funding in the field of industrial waste management; formation of logistics infrastructure facilities for waste management; creation of an appropriate cluster structure as an organizational form of partnership in the field of industrial waste management; development and implementation of tools for economic incentives for industrial waste disposal; implementation of the concept of reverse logistics in the context of the circular economy.

Protection of consumer rights in the world wide web in the context of ensuring sustainable well-being

The Internet is the result of scientific and technological development of society. Innovation in any field is evidence of the well-being of the population. That is why society often uses services via the Internet, which is a sign of sustainable develop-ment and determines the relevance of the article. The purpose of the study is to determine the principles of sustainable development of consumer rights protection in the global network and the legal basis for the operation of commercial activities in Ukraine. General theoretical (analysis, synthesis, concretization, generalization, method of analogy, modeling) and specific research methods (methods of logic, comparison) were used. The results of this study allowed to create a set of methods of safe behavior of the buyer in the world wide web, form in order to realize the bases of functioning of sustainable development of consumer protection. The au-thors suggest possible options for improving the legislation of Ukraine for Internet commerce. The significance of the results is that the article is useful for introducing changes in the Ukrainian legislation on the regulation of the rules of purchase and sale on the Internet.