Menopause is a major change in a women’s life, it refers to a permanent cessation of menstruation and fertility. The fast face of modern life has induced many problems like stress, anxiety, insomnia etc. associated with serious health problems. The most common disorders associated with menstruation among younger women are dysmenorrhea, pre-menstrual syndrome, menorrhagia, metrorrhagia. Aims and Objectives: To record the effect of handgrip exercise on QTc and RR interval in different phases of menstrual cycle and to compare with the baseline ecg values. The study was conducted on 40 medical (I MBBS) students from Mysore Medical College and Research Institute, Mysore. In this study a total of 40 female students aged between 17-19 years from 1st MBBS studying at Mysore Medical Collage and Research Institute, Mysore were selected as per the inclusion and exclusion criteria. Informed consent was obtained from each student. Data about the duration of previous two menstrual cycles and the days of menstrual bleeding were noted from the subjects statement. Subject monitored basal body temperature was used to identify phases of menstrual cycle. Ovulation was indicated by a sustained increase in the basal body temperature of at least 0.3°C after LH surge.