The paper describes the in situ investigation, site stratigraphy, field monitoring, data reduction, and subsequent time-domain analysis of soil–structure interaction from a full scale vessel impact loading of a bridge pier at the St. George Island Causeway. The in situ investigation included standard penetration testing, electric cone, dilatometer, and pressuremeter testing to identify soil stratigraphy, engineering properties (strength and moduli), and axial and lateral static pile resistance (T–z, and P–y). Field instrumentation included soil total stress and pore pressure gauges in front of and behind the pile cap, a fully instrumented pile (strain gauges along length), dynamic load cells to monitor barge impact loads, and accelerometers to monitor pier accelerations, velocities, and displacements. Analyses of the field data reveal significant dynamic forces within the soil–structure system as a result of the duration and magnitude of the loading. Inertia from the piers, cap, and piles provide significant resistance in the early portion of the impact. However, postpeak inertia (i.e., pier deceleration) resulted in maximum deformations of the pier. Soil damping provided most of the resisting force at the peak barge loading, whereas static soil resistance dominated at the peak lateral displacement. Time-domain finite element analysis of an impact event employing viscous soil dashpots, nonlinear P–y and T–z springs with nonlinear beam, and shell elements for the pier, cap, and piles resulted in reasonable load displacement predictions.