Spreading of fine (D50 ≤20μm) powders into thin layers, such as required by layer-wise additive manufacturing (AM) processes, typically requires a mechanism such as a roller that provides adequate shear and compression to overcome the cohesive forces between particles. We explore improved, roller-based spreading strategies for highly cohesive powders using an integrated discrete element-finite element (DEM-FEM) framework. We find that optimal roller-based spreading, quantified by maximum packing density and uniformity of layer thickness, relies on a combination of surface friction of the roller and roller kinematics, e.g., counter-rotation or angular oscillation, that impart sufficient kinetic energy to break cohesive bonds between powder particles. However, excess rotation speed (or shear stress) can impart excessive kinetic energy to the powder causing ejection of particles and a non-uniform layer, suggesting the existence of a process window of optimal spreading parameters. Interestingly, the identified optimal parameters for both investigated roller kinematics, i.e., angular velocity for counter-rotation as well as angular frequency and amplitude for rotational oscillation, result in a very similar range of roller surface velocities, suggesting roller surface velocity as the critical kinematic parameter. When these conditions are chosen appropriately, layers with packing fractions beyond 50% are predicted for layer thicknesses as small as ∼2 times D90 of the exemplary cohesive powder, and the layer quality is robust with respect to substrate adhesion over a 10-fold range. The latter is an important consideration given the spatially varying substrate conditions in AM due to the combination of fused/bound and bare powder regions. As compared to counter-rotation, the proposed rotational oscillation kinematics are particularly attractive because they can overcome practical issues with mechanical runout of roller mechanisms (which limit their precision).