Nowadays, as in the urban areas the space available for the construction of buildings is limited. So in limited space we have to construct such type of buildings which can be used for multiple purposes such as lobbies, car parking etc. To fulfill this demand, high rise buildings is the only option available. The performance of a high rise building during strong earthquake motion depends on the distribution of stiffness, strength and mass along both the vertical and horizontal directions. If there is discontinuity in stiffness, strength and mass between adjoining storeys of a building then such a building is known as irregular building. The present study focuses on the seismic performance of regular and vertical irregular building with and without masonary infills. In the present study G+11 building is considered for the analysis with modelling and analysis done on ETABS software v17.0.1. The earthquake forces are calculated as per IS 1893 (part 1): 2016 for seismic zone III. The width of strut is calculated by using equivalent diagonal strut method. Total five models are considered for the analysis i.e. regular building with bare frame, regular building with masonary infill, soft storey building with open ground storey, mass irregular building with masonary infill and vertical geometric irregular building with masonary infill. The non-linear static analysis (pushover analysis) and linear dynamic analysis (response spectrum analysis) are performed for all the models and thereby compare their results. From analysis, the parameters like performance point, time period, maximum storey displacement, maximum storey drifts, storey shears and overturning moments are determined and also comparative study is done for all the models. From the comparison, it is observed that the vertical geometric irregular building shows better performance under seismic loading and bare frame building shows inferior performance. Moreover, the performance of masonary infilled frame building is f