The objective of the study is to determine the impact of stress management strategies on the performance output in the commercial banking organization in Nigeria. The population of the study comprises of all the operational twenty one (21) commercial banking firms in Nigeria as at December, 2016, totaled at 64,846 employees. The sample size for the study is 398 and is determined using Taro Yamane’s formula. Bowley’s allocation formula is used in determining respective commercial banks sample size. Both primary and secondary sources of data collection are employed in this research, confirmatory factor analysis with Varimax rotation has been performed to examine whether the classification of the variable into the specific factors is valid or not. In this case individual approaches, organizational approaches for managing stress and consequence of stress on performance output. Kaiser-Meyer-Oikin (KMO) test is used to measure sampling adequacy accepting a weak threshold of 0.5 and Bartlett’s test of Sphericity is also adopted and Total Variance Explained (TVE) score is used to measure how data is distributed within a range and also how much response differs (accepted threshold is 0.6). Cronbach Alpha (α) reliability test is performed to assess internal consistency of measurement adopting a weak threshold of 0.6. Multiple regression test is used in the test of two (2) formulated hypotheses. The findings of the study revealed that strategies/approaches adopted for the management of stress in the banking organizations such as realistic goal setting, placement of employees in appropriate jobs, time management, prioritizing activities and schedules amongst others will have a positive impact on performance of employee in banking organizations. Another finding reveals that consequences of stress symptoms have a significant effect on performance output of employees in the commercial banking firms in Nigeria (i.e, increase height blood pressure, anxiety, irritability, job turnover, sleep disorder, insomnia, heart attacks amongst others). The study recommendation are that employee that are assigned responsibilities and task for performance be experienced and skillful enough to live up to expected standards of job performance so that stress will not catch up with them. Again, proper delegation of authority and responsibilities, proper job descriptions, determination of objectives of the organization, proper job designs to suit the skills and needs of the employee, establishment of employee wellness programs, proper communications amongst others, are good strategies to adopt in managing stress in banking organizations for optimal growth and performance.