One of the major challenges of constructing any high rise building for civil engineers is to make it earthquake resistant. This resistance largely depends on the building’s shape and structural system. A comparative study has been done in this paper about the seismic behavior and response of buildings having a regular plan and plan irregularity (re-entrant corners). The 5 building models considered in this study are 15 stories each, the same area and identical weight. Among the 5 building models, 2 are with a regular plan (square, rectangle) and the other 3 building models are with plan irregularity (re-entrant corners). All of them are modeled using ETABS 2015 program for Dhaka, Bangladesh (seismic zone 2). Static loads, wind loads and seismic loads are considered for each model and dynamic response under Bangladesh National Building Code (BNBC) 2006 response spectrum has been meticulously analyzed. A comparison for story displacement, base shear, story drift and time period has been established and explored for dynamic response spectrum among the models. The results show that buildings with irregularity have a greater value of time period, drift and displacement and hereby are more susceptible to damage during an earthquake or disaster.