<sec>A kind of off-axis meta-lens with large focal depth based on a single-layer metasurface is designed and fabricated. Our proposed off-axis focus is realized by combining the two functions of deflection and focus through phase superposition method, and the focal depth can be increased by optimizing the input aperture and off-axis deflection angle. Three-dimensional finite difference time domain (FDTD) method is used for numerical simulation to construct the off-axis meta-lens, then the off-axis meta-lens is fabricated and its focus performance is tested in a microwave anechoic chamber.</sec><sec>Experimental results indicate that at the designed electromagnetic wave frequency (9 GHz), the measured off-axis deflection angle is 27.5° and the focal length is 335.4 mm, which agree with the designed values of 30° and 350 mm. The measured full-wave half-maximum (FWHM) at the focal point is 48.2 mm, however, the simulated FWHM is 40.2 mm, which means that the imaging quality of the measured focus spot is slightly worse than the simulated one. This is mainly due to the fact that the actual parameters of the fabricated meta-lens are inconsistent with simulated parameters. In addition, during the measurement, the large sampling interval in the x- direction also leads to experimental errors.</sec><sec>The focusing efficiency of the off-axis meta-lens at the working frequency of 9 GHz is calculated to be 16.9%. The main reason for the low focusing efficiency is that the plasmonic metasurface works in the transmission mode, which can manipulate only the cross-polarized component of the incident wave, and the maximum efficiency will not exceed 25%. Moreover, the focal depths at 8 GHz, 9 GHz and 10 GHz are 263.2 mm, 278.5 mm and 298.2 mm, respectively, which are 7.02 times, 8.36 times and 9.98 times the corresponding wavelengths, indicating that a larger focal depth off-focus meta-lens is achieved. </sec><sec>This kind of off-axis meta-lens has a simple structure, good off-axis focus ability and large focal depth, which has potential applications in a compact and planar off-axis optical system and large focal depth imaging system. Although the working waveband in this article is the microwave band, according to the size scaling effect of the metasurface, it is also possible to design a large focal depth off-axis meta-lens in other bands such as visible light and terahertz bands by using the same method.</sec>