The Russian Federation borders with 18 foreign countries. Seven of them are NATO members as of March 2024. The state border of Russia passes through the territory of almost half of the constituent entities of the Russian Federation. The shelling of the territory of the Russian Federation by the armed forces of Ukraine radically changes the situation in the sphere of not only of military, but also of socio-economic security, primarily in the border regions of Russia. The issue of their protection, elimination of weaknesses and organization of society’s life in a new, unstable, largely unfavorable external environment is especially acute. The formation of resources necessary for solving these issues largely depends on the current level of economic development of the country and its border regions. The author’s purpose was to illustrate some aspects of the economic situation in the border regions of the Russian Federation, given the current circumstances where Russia’s adversaries are attempting to create areas of tension near the Russian borders, exemplified by Ukraine, Poland, and the Baltic States. To achieve this goal, the author solved several tasks. They are: selecting the subjects of the Russian Federation to be studied, determining the set of statistical indicators to be analyzed, and determining the length of the dynamic range for each indicator. We also constructed the dynamics of change for these selected indicators. The results of the author’s analysis of seven statistical indicators that reflect the socio-economic situation in 36 selected border regions of the Russian Federation are presented below. The analyzed statistical data are taken for the period from 1995 to 2021. The economic and statistical research was carried out on the basis of data from the Federal State Statistics Service of the Russian Federation, most of which are published in statistical collections “Regions of Russia. Socio-economic Indicators”. The article shows that a number of the studied parameters indicate the need to strengthen the economic power of the Russian border regions in modern and possible future conditions. The obtained results can be useful for legislative and executive authorities of the Russian Federation and the subjects of the Russian Federation in the development and implementation of the development policy of regions that have a particularly important strategic importance.