elderly with breast cancer, since the number of this group of patient is continuously growing. Objectives: The aim of this study is to describe the histologic subtype and biologic profile (protein markers) of breast cancer among older Balinese women aged 65 years and more. Methods: This is a retrospective descriptive epidemiologic study of all breast cancer cases that were recorded in the local cancer registry of Sanglah General Hospital, the largest cancer registry in Bali. Statistical analyses were conducted using descriptive statistics with the Statistical Package for the Social Sciences version 16.0 (SPSS). Results: A total of 1020 cases of breast cancer among Balinese women were recorded during the period of 1997–2013, of which 78 cases (7.6%) were diagnosed in elderly. Only 964 cases presented with the result of histopathology examination. Infiltrating ductal carcinoma (IDC) was the most common histologic type (80.0%), followed by infiltrating lobular carcinoma (ILC) (4.7%), mucinous carcinoma (1.9%), and medullary carcinoma (0.9%). An almost equal proportion of low grade IDC was recorded between the elderly and the younger group of patients (9.3% vs. 9.2%). However, high grade IDC was recorded for 53.7% of the elderly, compared with 41.5% of the younger group of patients. Meanwhile, a lower proportion of ILC was recorded for the elderly (2.6% vs. 4.6%). The same observation was also found for mucinous carcinoma (1.4% vs. 1.9%). As for the immunohistochemistry (IHC) profiling, only 158 cases presented with the result of the examination. The proportion of cases with ER+, PR+, and over-expressed HER2 were lower in the elderly (33.3% vs. 41.9%, 33.3% vs. 42.3%, 11.1% vs. 29.3%, respectively). Luminal A and Triple Negative cases were recorded in a higher proportion in elderly, compared to the younger group of patient (44.4% vs. 35.4%, and 44.4% vs. 34.7%, respectively). In contrast, Luminal B and over-expressed HER2 cases were recorded in a lower proportion in elderly (0.0% vs. 14.3%, and 11.1% vs. 15.0%, respectively). Conclusion: Histologic subtypes favoring a slower, more indolent pattern of growth and progression is less common in elderly of Balinese population. Furthermore, biologic features that favor worse prognosis are quite frequent in this population. These findings are in discordance to the widely-accepted concept of breast cancer in elderly and factors that contribute to this observation need to be elucidated in future studies. Disclosure of interest: None declared.