Automobile piston engines with a desaxial crank mechanism are characterized by increased vibration activity associated with a cyclic change in the pressure of the working fluid in the cylinders and inertial forces associated with the reciprocating and rotational movement of the crank mechanism moving masses. Properties reflecting the consumer properties of the engine, including acoustic characteristics, are largely determined by the level of vibration of the structural elements of the desaxial crank mechanism and, first of all, by the balance of inertial forces during operation. The article discusses balancing of five-cylinder four-stroke VR type engines with a desaxial crank mechanism and uniform flash alternation. The authors introduce formulas that can be used to determine and analyze moments of the inertia forces of the reciprocating and rotating masses arising in VR5 engines at the set values of the cylinder camber angle, the ratio of the crank radius to the connecting rod length and the relative displacement of the cylinder axis. A method of balancing the moments of inertia forces of the reciprocating and rotating masses is proposed.