Background: Eccentric training redresses the consequences of spastic muscle shortening by altering the length– tension characteristics of muscle to operate at longer lengths Purpose: Purpose of this study was to study the effect of eccentric control training on balance and gross motor function in children with Spastic Cerebral Palsy. Methods: The study was prospective controlled study, simple randomization plane used to assign participants, triple blind study (participant, outcomes assessor, data analysts). 40 children with spastic cerebral palsy were enrolled from the pediatrics' out-patient clinic, faculty of physical therapy, Cairo University. Participants randomly divided into experimental and control groups. The experimental group received 60 minute of neurodevelopmental technique and eccentric control exercise. While, 60 minute of neurodevelopmental technique was applied for the control group. Stability index of The Biodex balance system (primary measure) as well as standing and gait parameters of the gross motor function measures (secondary measure) were evaluated before and after the trail. Results: There was a significant difference between the control and the study group in the overall stability indices in favour of the study group (P<0.001) with confidence interval 95%. Significant increase in the values of GMFM post treatment of study group compared with the control group (p<0.02). Conclusion: Eccentric control exercise therapy in children with spastic Cerebral Palsy is an effective approach to develop balance and gross motor function.