The multi-institutional RTOG 0617 study compares the efficacy of high-dose (74 Gy) and standard-dose (60 Gy) radiotherapy for non-small cell lung cancer. The reported, unexpected outcome in the high-dose cohort not displaying a survival advantage differed from that observed in a previous multi-center study RTOG 0117. Patient heterogeneity may be attributed to the variation in radiotherapy effectiveness and might have explained why the high dose arm was not as effective as anticipated. This study aims to evaluate radiomic biomarkers with the potential to predict who would benefit from a high dose with predictive models built with radiomic characteristics. We analyzed 184 baseline planning CTs from DICOM images of patients in the high-dose cohort. The Radiomic features were extracted from the target structures within the GTV or ITV. Overall, 1130 radiomic characteristics were extracted from each patient using an open source software package. Furthermore, image pre-processing was performed with open source software. We used feature-selection methods, such as LASSO, Recursive Feature Elimination, forward selection, backward selection, Boruta, and Multivariate Adaptive Regression Spline (MARS), and evaluated their reduction efficiency and consistencies in feature selection. The MARS method provided the best results by identifying nine consistent features, which were used to build survival models. The accuracy of all models was estimated using 50-fold cross-validation. The Cox regression model was predictive with a C-index of 0.6552. The decision tree method exhibited the following: accuracy, 65.8%; AUC, 0.67; specificity, 70%; and sensitivity, 61%. The Ensemble Boosted Tree adopted an AdaBoost ensemble method with following characteristics: overall accuracy, 63%; AUC, 0.69; specificity, 73%; and sensitivity, 49%. The Ensemble Bagged Tree adopted the normal bootstrap aggregating method with the following characteristics: accuracy, 66.3%; AUC, 0.72; sensitivity, 77%; and specificity, 52%. Finally, the RUSBoosted tree method exhibited an accuracy of 65.8%, an AUC of 0.69, a sensitivity of 73%, and a specificity of 49%. Using the MARS method, we identified nine significant radiomic features. Using these features, 2-year survival predictive models were generated with reasonable performance. These nine features can also be used to calculate the prognostic index for patients to classify them into a high risk or low risk cohort. Hence determining who may benefit from a high dose prescription. Nevertheless, further investigation using more data and validation of the methodology is warranted.