Antibacterial Activity Research Articles

Antimicrobial-guided metabolomic analysis of essential oil derived from the Aotearoa New Zealand endemic plant Kunzea robusta (Kānuka).

Antimicrobial-guided metabolomic analysis of essential oil derived from the Aotearoa New Zealand endemic plant Kunzea robusta (Kānuka).

α-Mangostin encapsulated gellan gum membranes for enhanced antibacterial, anti-inflammatory, antioxidant and wound healing activity.

α-Mangostin encapsulated gellan gum membranes for enhanced antibacterial, anti-inflammatory, antioxidant and wound healing activity.

Molecular docking and dynamic simulation of sesamin from Piper crocatum Ruiz & Pav as an inhibitor of canonical NF-κB: Potential anti-inflammatory mechanism

Context: Red betel (Piper crocatum Ruiz & Pav) has several fingerprint compounds with antibacterial, antifungal, anti-inflammatory, antiseptic, and antioxidant activities. Aims: To evaluate the potential of P. crocatum active compound as an anti-inflammatory agent through in silico studies. Methods: The selected active compounds of P. crocatum, including kaempferritin, piperbetol, sesamin, piperine, and piperbetol were used in this study. The bioactive compounds of P. crocatum were analyzed for drug-likeness screening using the SwissADME and then analyzed using Lipinski’s rule to identify medicinal properties. The bioactive compounds of P. crocatum also predicted their toxicity using the web server https://tox-new.charite.de/protox_II/. The selected ligands and NF-kB proteins were then docked using Pyrx 0.8 software and visualized by Discovery Studio. Molecular dynamics simulation was used to obtain RMSF values using YASARA software. Results: Kaempferitrin, piperbetol, β-amyrin, and sesamin were predicted to be inactive in hepatotoxicity, carcinogenicity, mutagenicity, and cytotoxicity. Meanwhile, piperine was predicted to be active in hepatotoxicity and carcinogenicity and inactive in mutagenicity and cytotoxicity. Sesamin has a similar structure to the synthetic drug panobinostat. Sesamin has a binding affinity of -6.9 kcal/mol. While panobinostat has a binding affinity of -5.5 kcal/mol. The RMSD value showed that the compound-complex of NF-kB-sesamin was more stable than the compound-complex of NF-kB- drug (panobinostat). Conclusions: Sesamin from P. crocatum could be considered as an anti-inflammatory agent by inhibiting NF-kB based the in silico study.

Nano CaCO3 mediated in vitro and in vivo wound healing characteristics of chitosan films without added drugs.

Nano CaCO3 mediated in vitro and in vivo wound healing characteristics of chitosan films without added drugs.

Chitosan-based structures for skin repair: A literature review.

Chitosan-based structures for skin repair: A literature review.

Cyclodextrin modified biocompatible Chitosan-Cinnamaldehyde Schiff base hydrogels: Their antibacterial, antioxidant, and drug delivery potential.

Cyclodextrin modified biocompatible Chitosan-Cinnamaldehyde Schiff base hydrogels: Their antibacterial, antioxidant, and drug delivery potential.

Magnetic nanoparticles of Fe3O4 biosynthesis using Anacardium occidentale fruit extract: Evaluation of in vitro antioxidant, antibacterial, antidiabetic, anti-cholinesterase and cytotoxic activities

Magnetic nanoparticles of Fe3O4 biosynthesis using Anacardium occidentale fruit extract: Evaluation of in vitro antioxidant, antibacterial, antidiabetic, anti-cholinesterase and cytotoxic activities

Polysaccharide edible film-the new star in food preservation: A review.

Polysaccharide edible film-the new star in food preservation: A review.

Antimicrobial and insecticidal activity of spray dried juniper berry (Juniperus communis L.) essential oil microcapsules prepared by using gum arabic and maltodextrin.

Antimicrobial and insecticidal activity of spray dried juniper berry (Juniperus communis L.) essential oil microcapsules prepared by using gum arabic and maltodextrin.

Proline rich-39 (PR-39) antimicrobial protein alleviated lipopolysaccharide-induced intestinal barrier dysfunction in piglets by altering intestinal flora associated bile acid metabolism and in turn regulating TGR-5/NF-κB/MLCK/MLC pathway.

Proline rich-39 (PR-39) antimicrobial protein alleviated lipopolysaccharide-induced intestinal barrier dysfunction in piglets by altering intestinal flora associated bile acid metabolism and in turn regulating TGR-5/NF-κB/MLCK/MLC pathway.

Studies on Gelatin-Keratin-Chitosan Functionalized Silver Nanoparticles Based Bionanocomposite Films With Improved Antimicrobial and UV-Blocking Properties.

This study investigates the properties of a biocomposite film made from gelatin and sustainably sourced keratin incorporating chitosan-functionalized silver nanoparticles. Varied concentrations of chitosan solution (i.e., 0.4%, 0.6%, 0.8%, and 1% w/v) were used in the synthesis of silver nanoparticles, and their particle size, distribution, and antibacterial and antifungal activities were evaluated against foodborne pathogens (Escherichia coli, Staphylococcus aureus, Rhizopus stolonifer, and Aspergillus niger). The addition of keratin enhanced the film's tensile strength to 16.64 MPa, a 403% increase compared to the gelatin film. However, incorporating 2% chitosan functionalized silver nanoparticles reduced the tensile strength to 9.07 MPa compared to the Gelatin-Keratin film. The distribution of nanoparticles and the interaction between the polymer chains were analyzed using scanning electron microscopy and Fourier transform infrared spectroscopy. The composite films also exhibited significant UV blocking efficiency, achieving 99% blockage of ultraviolet A and 100% blockage of ultraviolet B. The biocompatibility of the films was tested with MG63 cell lines, showing that silver nanoparticle concentrations (0.3%-2%) improved cell viability to 87% after 96 h of incubation. These findings reveal that the bionanocomposite films exhibit strong antibacterial and antifungal properties, along with excellent biocompatibility, making them ideal materials for wound healing and tissue engineering applications.

Incorporation of co-encapsulated extracts of saffron petal and Stachys schtschegleevii into chitosan/basil seed gum/graphene oxide bionanocomposite: Effects on physical, mechanical, antioxidant, and antibacterial properties.

Incorporation of co-encapsulated extracts of saffron petal and Stachys schtschegleevii into chitosan/basil seed gum/graphene oxide bionanocomposite: Effects on physical, mechanical, antioxidant, and antibacterial properties.

Chemical Composition and Antimicrobial Effect of Essential Oil of Anthemis pauciloba Boiss. var. pauciloba from Türkiye

Anthemis pauciloba Boiss. var. pauciloba is one of four recognized varieties in Türkiye, locally known as “bol papatya.” Its flowers are traditionally used as a cold infusion to treat asthma. The aim of the research was to determine the chemical composition of essential oil (EO) of A. pauciloba var. pauciloba aerial parts obtained by hydrodistillation using a Clevenger-type apparatus, examined by GC-FID, and GC-MS, simultaneously. The EO was evaluated for antibacterial and antifungal activities against microbial strains utilizing the broth-microdilution technique. α-Thujone (28.7%), α-pinene (26.7%), and β-thujone (9.0%) were found as the main constituents of EO. The antimicrobial activity (Minimum Inhibitory Concentration) against gram-negative, gram-positive, and yeast was observed by the essential oil. The essential oil demonstrated the highest antimicrobial activity against Candida krusei (MIC: 1.25 mg/mL). The antimicrobial activity of the essential oil from the aerial parts of A. pauciloba var. pauciloba was evaluated for the first time in this study.

Identification and evaluation of active fractions from Radix Hedysari polysaccharides: Their regulatory impacts on intestinal flora and metabolism in mice.

Identification and evaluation of active fractions from Radix Hedysari polysaccharides: Their regulatory impacts on intestinal flora and metabolism in mice.

Multifunctional alginate-sinapic acid/arginine-strontium hydrogel for promoting diabetic wound healing.

Multifunctional alginate-sinapic acid/arginine-strontium hydrogel for promoting diabetic wound healing.

Preparation of sodium alginate and xanthan gum bionanocomposite films reinforced with hybrid halloysite nanotubes containing ZnO and licorice root extract for wound dressing applications.

Preparation of sodium alginate and xanthan gum bionanocomposite films reinforced with hybrid halloysite nanotubes containing ZnO and licorice root extract for wound dressing applications.

Valorization of metabolites of Kocuria marina DAGII in meat preservation using a sustainable approach

Valorization of metabolites of Kocuria marina DAGII in meat preservation using a sustainable approach

Surface Coating of Hydroxyapatite/Antibiotics Composite Layer onto Polyetheretherketone for the Improvement of Antibacterial and Bone Cell Growth Activities

Surface Coating of Hydroxyapatite/Antibiotics Composite Layer onto Polyetheretherketone for the Improvement of Antibacterial and Bone Cell Growth Activities

Ecofriendly Synthesis of CuO Nanoparticles Using Brassica Juncea (L.) Czern Seed Extract: A Green Approach for Effective Biological Applications

AbstractCopper oxide nanoparticles were synthesized by ecofriendly method using aqueous extract of Brassica juncea (L.) Czern seeds. Thus, obtained BJ‐CuO NPs were characterized using TEM, EDX, Raman spectra, DLS, zeta potential, UV–vis, FTIR, XRD, and SEM techniques. XRD analysis revealed monoclinic structure with 18 nm crystallite size. SEM studies confirmed the spherical morphology of produced BJ‐CuO NPs, further supported through TEM analysis (17.67 ± 5.45 nm). Raman spectra showed peaks at 292, 340, and 626 cm−1, which is attributed to Raman active modes for Cu–O stretching (Ag + 2Bg). The stability of the colloidal suspension was proved through DLS analysis with zeta potential value of −34.5 mV. The BJ‐CuO NPs had shown significant biological activities with IC50 values in µg/mL, namely, i) antioxidant (72.21), ii) anti‐inflammatory (77.77), and iii) antidiabetic activity (71.36). Further, the cytotoxicity studies on A549 and MCF‐7 cell lines through MTT test reveals moderate effect with IC50 values of 40.68 and 86.62 µg/mL. On screening BJ‐CuO NPs for antibacterial and antifungal activity against various strains, it shows significant activity with E. coli (18 ± 0.30) and A. Niger (18 ± 0.61). These results indicate that BJ‐CuO NPs hold significant potential for biological applications in future drug development.

One-step synthesis of hybrid copper humate-chitosan nanoparticles to control the development of human bacterial pathogens.

One-step synthesis of hybrid copper humate-chitosan nanoparticles to control the development of human bacterial pathogens.