Bacteria have been shown in recent years to sense population density and change their phenotype depending on their surroundings. Quorum sensing is a phenomenon that allows bacteria to control virulence factors and biofilm formation. Because of the increasing number of therapeutic failures, Helicobacter pylori is our primary focus in this case. Obliteration of anH. pylori infection is getting decreasingly hard. Antibiotic resistance is extensively caused by biofilm conformation, a medium inH. pylori regulated by QS (signal patch- AI- 2) and regarded as a sensitive marker for quorum- seeing bacterial communication. A new result for quorum seeing attenuation was delved in this design, which involves the use of computer- supported medicine design to identify implicit quorum seeing impediments as a relief for antibiotics. Six campaigners were computationally linked as implicit QSIs from the 25 composites screened due to their high list affinity for the chemoreceptor TlpB and low toxin. This emulsion could be used to either stop or reduce bacterial communication and thus inhibit the development of QS-controlled traits by in silico method against nosocomial infection causing drug resistant H.pylori. In-vitro studies also shown that it inhibits the formation of H. pylori biofilms.