Background Of Ischemia Research Articles

Новые возможности нейропротекторной терапии при дегенеративных и ишемических поражениях сетчатки и зрительного нерва

The presented literature review highlights the significance of the ischemia as a reason of reducing visual acuity in case of having such diseases as rhegmatogenous retinal detachment, primary open-angle glaucoma, AION and optic nerve atrophy. The expediency of prescribing “Cytoflavin” in the background of ischemia in case of neurodegenerative eye diseases is justified. The evidence of the effectiveness of this medicine in ophthalmological practice is provided.

Incidence of peptic ulcers accompanied by gastrointestinal bleeding after surgery for critical lower limb ischemia

To study the incidence of peptic ulcers accompanied by gastrointestinal bleeding after surgery for critical lower limb ischemia and their relationship with the factors predisposing to mucous membrane damage. The study involved 94 patients with critical lower limb ischemia who were eligible for open bypass surgery. All patients underwent preoperative gastro- and duodenoscopy. The patients were followed up for 1 year, while the relationship between the nature of the lesion of the proximal gastrointestinal tract mucosa and the duration of pain syndrome against the background of ischemia, painkiller consumption and redo surgery. All study participants had lesions of the mucous membrane of the stomach and duodenum: inflammatory changes were identified in 92.6% of patients, ulcerative defects in 7.4%. When conducting a correlation analysis, we obtained a weak and moderate strength of the relationship between the duration of rest pain and severity of mucous membrane lesion and strong correlation between painkiller consumption and endoscopic data. Postoperative gastrointestinal bleeding was more common after redo reconstructive surgery or amputation compared to one intervention (7.7% and 1.8%, respectively). Various lesions of gastrointestinal mucous membrane are diagnosed in all patients with critical lower limb ischemia. It is associated with the underlying disease and painkiller consumption. Risk of bleeding is higher after redo surgery and amputations. Prevention of lesions requires comprehensive examination of patients and individual approach.

Influence of chronic ischemic disorders in the prostate on the development of benign prostatic hyperplasia

Purpose of the study. To assess the degree of influence of ischemic disorders in the prostate on the level of androgens.Materials and methods. This was an experimental study that included 20 white non-linear sexually Mature rats. All animals were divided into 2 equal groups: main and control (intact). In the main group of animals (n=10), we created a model of chronic ischemic disorders in the prostate by partial ligation of the inferior Vena cava. After 1.5 months, we conducted a hormonal study in all rats (n=20) — determining the concentration of androgens (testosterone, dihydrotestosterone) and estrogens (estradiol) in the blood of animals and prostate tissue.Results. In the blood of animals of both groups, the level of total testosterone and estradiol did not significantly differ (p>0.05). The level of dihydrotestosterone in the blood serum of rats of the main group on the background of ischemia was reduced by 18.1%, compared to the intact group (p>0.05). However, we detected elevated levels of testosterone (p<0.05) and dihydrotestosterone (p>0.05) in prostate tissue against the background of chronic ischemia.Conclusions. Chronic ischemic disorders in the prostate can be an independent pathogenetic factor in the development of BPH. Vascular damage leads to impaired blood flow and hypoxia, with increased tissue concentration of testosterone, which potentiates the development of BPH.

Changes in the composition of proteins in the blood during the period of ischemia-reperfusion syndrome, modeled by a violation of blood flow in the liver

On the experimental model of liver ischemia-reperfusion, quantitative changes in protein composition in the blood of white outbred rats were investigated. It was found that against the background of a 10-minute ischemia, the total protein content decreased by 0,9%, albumins by 1,5% (p0,05). The content of globulins practically did not change, and the content of fibrinogen increased by 33,3% (p0,05). In the corresponding periods of reperfusion compared with intact values, the content of total protein and albumins decreased, and globulins and fibrinogen increased. The intensity of changes in the quantitative and qualitative content of proteins in the blood of animals depended on both the duration of the ischemia period and the duration of reperfusion. At the same time, the increase in the level of globulins in the blood occurred more intensively during reperfusion after 20 minutes of ischemia. Thus, against the background of ischemia, there are changes in the quantitative composition of plasma proteins (total protein, albumins, globulins, fibrinogen). As the duration of ischemia increases, pathological changes increase. With reperfusion, the process continues unidirectionally, but against the background of a deeper ischemia lasting 20 minutes, some parameters of the pathological changes in the blood composition are less pronounced than against a background of reperfusion after a 10-minute ischemia. This phenomenon is explained by the activation of the protective and adaptive functions of the body.

Differentiation of fatty tissue stromal cells under different conditions of experimental cell transplantation

Fatty tissue has been lately considered by researchers as an accessible source of autological stem cells. The problem of factors which influence the directed differentiation of stem cells is still important. Experimental researches have been conducted on rats with simulated limb ischemia. Stromal-vascular fraction of fatty tissue was injected to the experimental animals both with limb ischemia and to those with intact extremities. Imunohistochemical researches (determination of antibodies expression to von Willebrand factor, of collagen IV type and vimentin) of processes, which take place with introduced multipotential stromal cells, the number of which is great in stromal-vascular fraction of fatty tissue against the background of ischemia and without it, have been conducted. These results allow defining the future subsequent development of this direction of researches.