Under the background of Internet Plus, the rapid development of the mobile Internet technology has led to the widespread use of the PCs and smartphones, bringing out new chances for college English mobile learning. More importantly, with the trend of globalization, the complex situation has set higher demands for this generation. In order to promote college students’ English learning effectiveness and enhance comprehensive English skills, this paper explores possible mobile learning patterns based on multi-modal learning that college students can apply in English learning, according to the theories of the Multi-modal Discourse Analysis and mobile learning. Included in the study are the employment of questionnaires and interviews. The results show that teachers’ construction of multi-modal teaching and students’ after-class multi-modal learning play a significant role in improving college students’ English proficiency. The research, therefore, will provide some possible insight into cultivating college students’ comprehensive English skills to adapt to the changing society.