Abstract With hyperspectral instruments measuring radiation emitted by Earth and its atmosphere in the thermal infrared range in multiple channels, several studies were made to select a subset of channels in order to reduce the number of channels to be used in a data assimilation system. An optimal selection of channels based on the information content depends on several factors related to observation and background error statistics and the assimilation system itself. An optimal channel selection for the Cross-track Infrared Sounder (CrIS) was obtained and then compared to selections made for different NWP systems. For instance, the channel selection of Carminati has 224 channels also present in our optimal selection, which includes 455 channels. However, in terms of analysis error variance, the difference between the two selections is small. Integrated over the whole profile, the relative difference is equal to 15.3% and 4.5% for temperature and humidity, respectively. Also, different observation error covariance matrices were considered to evaluate the impact of this matrix on channel selection. Even though the channels selected optimally were different in terms of which channels were selected for the various matrices, the results in terms of analysis error are similar. Significance Statement Satellites measure radiation from Earth and its atmosphere in the thermal infrared. Those radiance data contain thousands of measurements, called channels, and thus, a selection needs to be done retaining most of the information content since the large number of individual pieces of information is not usable for numerical weather prediction systems. The goal of this paper is to find an optimal selection for the instrument CrIS and to compare this selection with selections made for different numerical weather prediction systems. It was found that even though the channels selected optimally were different in terms of which channels were selected compared to other selections, the results in terms of precision of the analysis are similar and the results in terms of analysis error are similar due to the nature of hyperspectral instruments, which have multiple Jacobians overlapping.