Frequent weather or climate changes, coupled with the topography of Cirebon and Majalengka which are mostly lowlands and close to the sea, raise concerns that flood disasters can occur if mitigation is not done early. This research aims to predict and map rainfall and runoff discharge as a flood mitigation effort in the Cirebon and Majalengka areas. The method used in this research is the Backpropagation Method, which resembles the way the neuron system works in the human brain to learn patterns, optimize weights and biases, and reduce the error rate (mean square error) so that the predicted value is closer to the actual value. The results showed that Cirebon was predicted to have the highest rainfall of 2471 mm in 2048, based on prediction data from BMKG Penggung Station, while Majalengka was predicted to have the highest rainfall of 2922 mm in 2048, based on prediction data from BMKG Kertajati Station. The largest runoff discharge in the Cirebon region occurred in Susukan District (51.96 km²) with a discharge of 68.648 m³/second (Q25), and in the Majalengka region occurred in Lemahsugih District (78.64 km²) with a discharge of 104.16 m³/second (Q25). The implications of this research include mitigation efforts that can be carried out, such as reducing development above drainage channels, reforestation, maintaining open areas, reducing land use change, conservation of rivers and catchments, construction of flood embankments, and issuance of related regulations.