AbstractPurpose: This study explored the perceptions of people with a lower limb amputation as to important factors contributing to their low back pain (LBP). Method: Semi-structured interviews were conducted (three focus groups and two individual interviews), with 11 participants with lower limb amputation and on-going LBP. The discussions were analysed using the General Inductive Approach. Results: Five major categories were identified with “uneven posture and compensatory movements” of the back perceived to be the main contributor to LBP. “Fatigue” during functional activities and “prosthesis-related factors” may affect the “uneven movements” of the back further leading to LBP. “Multiple pain conditions” (i.e. phantom limb pain, non-amputated limb pain) could influence the pain perceptions contributing to LBP. “Self-management strategies” in the form of maintaining optimal physical fitness and support from health care professionals helped to manage LBP symptoms, thereby assisted in preventing chronicit...