The present work investigates the application of vortex generators for separation control in axisymmetric isolator flows. Reynolds-Averaged Navier-Stokes computations were performed to simulate a Mach 2.5 flow past a half-isolator geometry with a 20∘ axisymmteric compression ramp based on the experiments of Funderburk and Narayanaswamy at North Carolina State University. Single vortex generator and a vortex generator array placed upstream of the shock-induced separation region were investigated. Near wall streamlines, surface pressure contours and density contours on crosswise planes were compared with experiments for flow control using a single vortex generator. Results indicate that the present computations are able to capture the wake and shock structures, and also predict reduction in the streamwise extent of flow separation downstream of the device trailing edge. Finally, the effects of the shape/orientation (forward facing/backward facing) of a single vortex generator, and the design of an array of three vortex generators (with devices of similar and mixed orientations) on the flow separation were also investigated. Contours of near-surface streamwise velocity showed that device orientation had a strong effect on separation control, which is attributed to the differences in the primary streamwise vortices shed in the two cases. Further, the overall reduction in the footprint of separated flow was determined to be most with the use of an array of vortex generators with mixed orientations.