Abstract With the onset of the fossil energy crisis, demand for oil has skyrocketed, and the spiral axial flow gas-liquid mixing pump has emerged as the primary piece of equipment for deep-sea oil extraction. However, at high gas content, the problems of separation of mixed media from hydraulic components, gas-liquid separation and gas phase aggregation are faced. The difficulties of gas-phase aggregation and bubble trajectory in the impeller channel have received much attention, while the problem of increased medium flow resistance induced by flow separation has received less attention. The spiral axial gas-liquid mixing pump is numerically calculated using the Eulerian multiphase flow model and the SST k- turbulence model in this work. The pump is designed with the design flow rate Q = 100 m3/h, rotational speed n = 4500 rmin, and head H = 30m by arranging guide slots with different relative depths and different number of slots to reduce the dissipative vortices, thus reducing the flow resistance in the 1/5 region behind the suction surface. The findings reveal that when the relative depth of the slots is 1/7 and the number of guide slots arranged is 5, the highest drag reduction rate in this location is 69.6% under the design flow condition. When the relative depth of the guide channel is1/7 and the number of guide channels is 3, the performance of the mixing pump is improved most, with an efficiency increment of 1.9% and a head increment of 4.2%, which can provide technical support for the flow resistance reduction of gas-liquid mixing pumps.