The performance and stable operating range of compressors are critical to the efficient operation of various turbomachinery systems. This paper proposes a multi-level optimization strategy combining the uni-uniform direct free deformation method, Linux partitioned CPU accelerated parallel computing technology, multi-objective particle swarm optimization algorithm and downhill simplex algorithm, which improves design efficiency. Numerical results show that after optimization design, the average value of peak efficiency and stall margin increases. The flow mechanism of compressor performance improvement after optimization lies in the reduction of a low-velocity separation zone in stator hub region. Moreover, the experiment study confirms the reliability and accuracy of the optimization design method and found that flow instability triggering mode, propagation characteristics of the stall cell, and surge frequency are changed after optimization design. Setting a probability distribution threshold for autocorrelation coefficient and cross-correlation coefficients can be used to predict the arrival of the surge condition.