Abstract Purpose: Ultraviolet radiation is the primary cause of skin cancer.1,2 Other risk factors include fair skin, moles, family history, and history of sunburns.1,3 Photoprotective practices and regular skin examinations can help prevent skin cancer associated with ultraviolet radiation,5-8 underlining the importance of prevention and early detection. However, dermatological health disparities, such as limited access to dermatologists and inadequate awareness of sun protection practices, present significant challenges to effective prevention and early detection efforts. Recognizing and addressing these barriers is crucial, particularly amongst minoritized groups, who carry a higher burden of skin cancer morbidity and mortality.9 The Sun Bus, affiliated with the Colorado Melanoma Foundation, travels across the United States providing free skin cancer screenings and prevention education to reduce the incidence of skin cancer.1 In collaboration with the Sun Bus, Paul L. Foster School of Medicine and Myth Busters at Texas Tech University Health Sciences Center El Paso organized a bilingual skin cancer education and screening community event in El Paso, Texas. The main objectives were to debunk skin cancer myths prevalent in underserved communities and to strengthen prevention initiatives. Methods: Participants were administered optional surveys assessing their skin cancer knowledge and prevention behaviors before and after attending the session. Demographic data was collected, and pre-event and post-event knowledge were quantified using unpaired T-tests. Results: The event was attended by over 100 people. Over 80% of the event attendees were Hispanic. Among them, approximately one-third had only graduated high school, another third had completed college, and one-quarter held advanced degrees. The ages of participants ranged from 18 to over 75. Notably, 22% of respondents were uninsured. All survey respondents reported learning something new from the event. The performance from the pre-test to the post-test improved significantly by 7.04% (p=0.017). Additionally, attendees reported better knowledge about where to apply sunscreen and the importance of wearing sun-protective clothing. Conclusion: The Sun Bus Community Initiative proved to be an effective method for participants to learn about sun protection, skin cancer prevention and screening. This initiative could serve as a model to implement in other underserved communities to improve skin cancer awareness and prevention. Citation Format: Daniel Lovasz, Brian Kan, Hannah Riva, Shravya Kichena, Fabiola Ramirez, Whitney Shaffer, Julia Guido, Mariana Arajuo-Rincon, Jessica Chacon. Empowering underserved communities: The impact of the Sun Bus and Texas Tech on skin cancer awareness and prevention in “Sun City” [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B056.