Awareness In Dementia Research Articles

Cognitive Reserve and the Relationship Between Depressive Symptoms and Awareness of Deficits in Dementia

Depression and low cognitive reserve are linked to impaired awareness in dementia, although their relative contributions are unknown. The authors investigated the impact of depressive symptoms and cognitive reserve on awareness in questionable and mild dementia. Sixty-six patients completed measures of cognitive reserve, awareness, and depressive symptoms. Cognitive reserve and its interaction with depressive symptoms accounted for significant proportions of variance in awareness; depressive symptoms alone did not. Depressive symptoms and awareness were positively related in high, but not low, cognitive reserve groups. Findings suggest cognitive reserve moderates the depression/awareness relationship in dementia, which may explain previously discrepant findings.

Longitudinal assessment of awareness in early-stage Alzheimer's disease using comparable questionnaire-based and performance-based measures: A prospective one-year follow-up study

Few studies of awareness in dementia have taken a longitudinal perspective, yet exploring the ways in which awareness changes over time may offer important information about the processes involved and the relationship between awareness and other variables. The present study explored in detail the patterns of change in awareness scores over time for a group of 12 participants with early-stage Alzheimer's disease using a multi-dimensional measure giving comparable participant-carer and postdiction-performance discrepancy scores. There were small, non-significant increases in mean discrepancy scores for each of these components of the assessment, with similar patterns for questionnaire-based and performance-based ratings. The small changes that were observed reflected both participant and informant factors. The majority of participants showed only very minor changes; others showed changes in the direction of either reduced or increased awareness. There was no significant association between change in mean discrepancy score and change in MMSE score over time, although there was a significant decline in MMSE scores at follow-up. The observation of different longitudinal trajectories for awareness scores, reflecting increased or decreased awareness or no change, may indicate the operation of different processes affecting the expression of explicit awareness that can be understood within a biopsychosocial formulation of this complex construct.

Perceptions of change over time in early-stage Alzheimer's disease

Emerging models of subjective experience, awareness and coping in early-stage dementia may usefully be enhanced by incorporating a temporal perspective. As an initial step in this direction, we undertook a prospective one-year follow-up of participants with a diagnosis of early-stage Alzheimer's disease whose accounts had contributed to the development of Clare's phenomenological model of awareness incorporating the continuum model of coping in early-stage dementia. All 12 participants from the original study completed a follow-up interview one year later. Interpretative phenomenological analysis was used to identify emergent themes. All participants continued to demonstrate some awareness of difficulties with memory, but individuals varied in their evaluations of the extent and implications of these changes, with the majority tending towards more normalizing explanations. Many were nevertheless making practical adjustments to their activities, and the need to renegotiate relationships was a prominent issue. Subsequently, the data were examined for evidence of the themes identified in the original study, the initial model was reapplied, and changes in individual coping style over time were explored through case study analysis. The range of processes and coping styles observed across participants 12 months earlier was still apparent, with some indication of increased polarization between self-maintaining and self-adjusting styles of coping. A small number of participants showed significant changes in coping style, with changes occurring in both directions. The findings suggest that expression of awareness interacts with coping style, illustrating the need to consider both factors in combination in order to better understand individual expressions of awareness of change.

Awareness in dementia: A review of assessment methods and measures

A comprehensive range of literature on awareness in dementia published in peer-reviewed journals during the last 15 years was reviewed with the aim of extracting details of the methods and measurement instruments adopted for the purposes of assessing awareness. Assessment approaches fell into five categories: clinician rating methods, questionnaire-based methods, performance-based methods, phenomenological methods, and multidimensional or combined methods. Ranges of objects of awareness assessment were identified both within and across domains. Strengths and limitations of methods in each category were identified. Reasons for the inconclusive findings from research using the methods described here were considered, and suggestions for future directions were made.

Awareness in dementia: Ethical and legal issues in relation to people with dementia

Our improved understanding of the experience of people with dementia provides a new impetus to address legal and ethical issues. This paper explores emerging issues in relation to awareness in dementia and its impact on legal and ethical matters. The different approaches and principles demonstrated in relation to ethical issues are discussed, with an exploration of the concepts of beneficence, non-maleficence, autonomy, and paternalism. Application of these concepts is discussed in relation to advance directives, capacity, and decision making, participation in research and treatment, including informed consent, and truth telling. The tensions that exist between the imperatives of doing no harm and of maintaining autonomy in addressing legal and ethical issues are highlighted, and attention drawn to the manner in which the attribution of unawareness is used to justify withholding autonomy. The review emphasizes the importance of considering competency and awareness as being multi-faceted, to be understood in the context of social interaction.

Awareness in dementia: A review of clinical correlates

This article provides a review of the literature on clinical correlates of awareness in dementia. Most inconsistencies were found with regard to an association between depression and higher levels of awareness. Dysthymia, but not major depression, is probably related to higher levels of awareness. Anxiety also appears to be related to higher levels of awareness. Apathy and psychosis are frequently present in patients with less awareness, and may share common neuropathological substrates with awareness. Furthermore, unawareness seems to be related to difficulties in daily life functioning, increased caregiver burden, and deterioration in global dementia severity. Factors that may be of influence on the inconclusive data are discussed, as are future directions of research.

Awareness in dementia: A subject for scrutiny

Awareness is an important concept in dementia care, with significant implications for the well-being and support needs of people with dementia and of their family members and carers. For example, h...

Awareness in dementia: Conceptual issues

There has been a recent proliferation of studies exploring awareness in people with dementia and, as is the case with similar studies in other clinical areas, results are generally mixed and inconsistent. One of the reasons underlying variability in study results relates to the complexities around the concept of awareness itself. Two sources of conceptual problems are explored. First, the meaning of awareness is examined and, within the dementia literature, various conceptualizations of awareness are identified which could be traced to three broad frameworks within which awareness and related terms are conceived. Differences between meanings of awareness are thus highlighted and the importance of making such differences explicit in studies was discussed. Second, the relational aspect of awareness is raised as a crucial issue determining the phenomenon of awareness elicited in clinical practice. Thus, in dementia, awareness is related to various “objects” including the illness as a whole, memory problems, activities of daily living, affective changes and many others. In each case, however, the object of awareness will elicit a different phenomenon of awareness, again carrying implications for the generalizability of study results. Clarification of conceptual problems is essential for future work in this area in order that empirical studies can provide meaningful answers concerning the therapeutic and predictive validity of different aspects of awareness.

Self awareness and personality change in dementia

Background: Loss of insight is a core diagnostic criterion for frontotemporal dementia (FTD), whereas failure to recognise cognitive deficits and unawareness of disease (anosognosia) are well established findings in Alzheimer’s...

Cognitive reserve and anosognosia in questionable and mild dementia

Cognitive reserve (CR) theory posits that the clinical presentation of individuals with the same brain disease varies based upon premorbid variables (e.g., education, occupation, reading ability). Anosognosia (decreased insight regarding one's deficits) is common in dementia and has implications for safety, treatment, and caregiver burden. The current study examined the role of CR in anosognosia in individuals with mild dementia. Participants were individuals diagnosed with questionable or mild dementia (Clinical Dementia Rating 0.5 or 1) after neuropsychological evaluation. Anosognosia was measured by informant–patient discrepancy on the Cognitive Difficulties Scale. High and Low CR groups were created based upon reading performance. Low CR showed greater anosognosia than High CR. Anosognosia was associated with reduced reading performance, even after controlling for global cognitive decline. These findings suggest CR is related to anosognosia in questionable and mild dementia, and have clinical implications for the assessment of awareness in dementia.

La démence dans l’espace de la conscience

This research studies the self awareness in dementia. Using L’Écuyer and Tap’s models like a structural psychic organisation, opening to the subject himself, we analyse the self description of Claudie suffering from dementia. The content analysis underscores the presence of personal identity, sustained by a self feeling and a self awareness.

Awareness in Dementia: New Directions

Awareness in Dementia: New Directions

Developing Awareness about Awareness in Early-Stage Dementia

Unawareness in dementia is often viewed as a ‘symptom’ that is wholly or primarily the product of biological factors. While neurological damage may be sufficient to produce unawareness in some disorders, it is argued that this is not generally the case in early-stage dementia. Instead, it is suggested that the apparent degree of awareness is an expression of adaptive psychological responses constructed in a social situation in the context of neurologically based cognitive impairment. Drawing on examples from detailed interviews with people who have dementia and their partners, the contribution of psychological and social factors to the expression of awareness is explored. It is further argued that, because evaluations of awareness are constructed in dialogue through the interpretative activity of the researcher or clinician, reflexivity is essential in considering awareness.

Exploring the Meaning of Symptom Awareness and Unawareness in Dementia

This interpretive phenomenological study explores the commonalities and differences in how people with dementia understand the meaning of their symptoms, comparing those who are aware of their impairment, those who are unaware, and those who have mixed awareness. Participants included five women and four men with mild to moderate Alzheimer's disease. The Anosognosia Questionnaire-Dementia (AQ-D) was used to measure symptom awareness, and in-depth interviews and participant observations were conducted to gather qualitative data about the meaning of symptoms. AQ-D results identified a range of awareness across the nine participants. Three were aware of their symptoms, three were unaware, and three had mixed awareness. Interpretive analysis of the qualitative data revealed three meaning narratives that illustrate qualitative distinctions in symptom experience across the different levels of awareness: (a) “Everything works more slowly” is a narrative of awareness; (b) “It's just old age” is a narrative of unawareness; (c) “It does not stick in the brain” is a narrative of mixed awareness. Such narratives offer important clues about the meaning and significance of symptoms for people with dementia. Nurses might use this information to tailor strategies for interacting with and offering support to people with dementia, depending on each individual's level of awareness.

Awareness of cognitive deficits and anosognosia in probable Alzheimer's disease.

We examined the relationship between unawareness of cognitive deficits and psychiatric and neuropsychological manifestations in 181 patients with probable Alzheimer's disease (AD). Patients unaware of their cognitive deficits were more cognitively impaired, as measured by the Mini-Mental State Examination, and had a specific defect in 'frontal/executive' functions. The presence of major depression, delusions and hallucinations was no more likely among patients who were aware of their cognitive impairment than among those who were not. These findings have important implications for the understanding of anosognosia and deficit awareness in dementia.

Deficit awareness in dementia: Relevance to the clinical diagnosis of Alzheimer's disease: B.R. Ott, J. Tornabene, and B.S. Fogel. Department of Clinical Neurosciences; Brown University, Providence, Rhode Island, U.S.A.

Deficit awareness in dementia: Relevance to the clinical diagnosis of Alzheimer's disease: B.R. Ott, J. Tornabene, and B.S. Fogel. Department of Clinical Neurosciences; Brown University, Providence, Rhode Island, U.S.A.