This article explores the crucial role of higher education institutions in catalysing regional innovation ecosystems. In particular, it aims to study how polytechnics in Portugal have been involved in this process. The research utilizes an exploratory and reflective case study approach to present real-world evidence of collaborative efforts within innovation networks that involve both businesses and the social economy. Thus, the study raises awareness of collaborative innovation and entrepreneurship networks, emphasizing genuine interactive learning and knowledge exchange. Polytechnic institutions can enhance regional competitiveness by providing education and training for future entrepreneurs and highly skilled professionals, as well as offering technological and managerial solutions that drive value creation and the emergence of new businesses and markets, potentially even on an international level. The study also emphasizes the fourth mission of higher education institutions, particularly polytechnic institutes, focusing on empowering communities through social innovation projects for sustainable local and regional development.