Influenza A virus continues to have a devastating effect on livestock, especially in Africa typified by lack of standardized prevention protocols and low level of compliance to biosecurity. Pig handlers are more vulnerable since pigs serve as a mixing vessel for genetic re-assortment, giving rise to a pandemic strain. Therefore, a descriptive and cross sectional survey was carried out between January 2019 and July 2019 on 40 pig keepers in areas with previous outbreaks of avian influenza in the Greater Accra Region of Ghana. A structured interviewer-administered questionnaire was used to obtain information on socio demographic characteristics, level of awareness and knowledge on influenza A, and on the biosecurity measures. Data collected was analyzed using Statistical Package for Social Sciences (SPSS) version 25. Chi-square was also employed to define association between variables at 0.05 significant levels. Generally, respondents who were not aware and also ignorant of the mode of transmission of the virus constituted the majority, slightly above 60%. Again, about 30% of the respondents were informed through radio and television. Surprisingly, extension officers contributed the least, 2.5% with information to farmers. Knowledge on mode of transmission and level of awareness were significantly correlated (p ⤠0.05) with level of education. There was a moderate biosecurity compliance among the respondents, representing 60% on the average. There was also a positive correlation between socio demographic characteristics, such as level of education and age of respondents, and adoption of some basic biosecurity measures. Therefore, integration of socio demographic characteristics, such as education in addition to source of information in the design of preventive measures and the adoption of biosecurity is significantly scalable.