Average Uric Acid Level Research Articles

#2640 Hyperuricemia in Gitelman syndrome 132 patients

Abstract Background and Aims Thiazide diuretics, the most common prescription for hypertension, were partly restricted by the hyperuricemia induced by the impairment of uric acid clearance serum uric acid. Gitelman syndrome (GS, OMIM263800), caused by mutations of the SLC12A3 gene encodes the thiazide-sensitive human Na–Cl co-transporter (hNCC), might shed light on the precision mechanism of hyperuricemia induced by Thiazide diuretics. Method We retrospectively reviewed 132 GS patients and pertinent articles and analyzed their clinical and genetic characteristics with or without hyperuricemia. Our study also employed Illumina Human Asian Screening Array-24 + v1.0 (ASA) gene chips to screen available samples from 87 patients with Gitelman Syndrome, which included a subgroup of 17 individuals exhibiting elevated uric acid levels characteristic of GS. Results The average uric acid level of 132 genetic-confirmed GS patients was 351.4 ± 95.1 µmol/l, with 21.2% hyperuricemia (mean 482.1 µmol/l) and 2 cases of gout. The GS patients with hyperuricemia had higher BMI (24.3 ± 3.9 vs. 21.6 ± 3.5 kg/m2, P = 0.001), lower FEUA (4.6 ± 1.0 vs. 7.0 ± 2.7%, P < 0.001), urinary calcium/creatinine (0.05 vs. 0.11 mmol/mmol, P = 0.01), and△FECl (0.6 ± 0.4% vs 1.2 ± 1.1%, P = 0.02) of the HCT test, indicating more severe NCC function injury. Fisher's exact test yielded non-significant associations of the ten uric acid-predicting SNPs between the patients with or without hyperuricemia at the conventional P-value cut-off of 0.05. Conclusion The prevalence of hyperuricemia in GS patients exceeds that observed in the general population. GS patients with hyperuricemia might be because of a high body mass index (BMI) and more severe impairment of NCC function, which suggested the crosstalk between NCC and Uric acid transporter.

Relationship Between Hyperuricemia and Hypertension in Diabetic Patients Undergoing Hemodialysis

Background: Diabetes is a prevalent chronic disease and is considered a risk factor for other chronic diseases. Various studies have pointed out the relationship between uric acid and type 2 diabetes. Objectives: This study aimed to investigate the relationship between hyperuricemia and hypertension in diabetic patients undergoing hemodialysis. Methods: The descriptive-analytical cross-sectional study was conducted on dialysis patients referred to the Comprehensive Center for the Treatment of Special Diseases in Birjand in 2022. Data were collected through a checklist, which included information such as age, sex, duration of hemodialysis, duration of diabetes, history of underlying diseases, blood pressure, and serum uric acid level. The data were analyzed using SPSS 26 software and chi-square, Fisher's exact, Mann-Whitney tests with a significance level of 0.05. Results: Hypertension was present in 61 (85.9%) of patients. The average uric acid level was 5.9 ± 1.12, and hyperuricemia was observed in 11 (15.5%) of patients. Although the rate of hyperuricemia was higher in patients with high blood pressure [10 (16.4%) vs. 1 (10%)], no significant relationship between hyperuricemia and high blood pressure was observed (P = 0.605). Additionally, no significant relationship was observed between the average uric acid level and demographic factors (age, sex, duration of dialysis, and average blood sugar) (P > 0.05). Conclusions: According to the present study's results, the rate of hyperuricemia in dialysis patients with high blood pressure is higher than in patients without high blood pressure. However, due to the non-significance of this relationship, there is a need to conduct studies with a larger sample size to truly understand its relationship with high blood pressure in diabetic patients undergoing hemodialysis.

Distinct uric acid trajectories are associated with incident cardiac conduction block

BackgroundThe association of longitudinal uric acid (UA) changes with cardiac conduction block risk is unclear. We aimed to identify the trajectories of UA and explore its association with cardiac conduction block.MethodsA total of 67,095 participants with a mean age of 53.12 years were included from the Kailuan cohort in Tangshan, China, who were free of cardiac conduction block and with repeated measurements of UA from 2006 to 2012. UA trajectories during 2006 to 2012 were identified by group-based trajectory modeling. Cox proportional hazard regression models were used to assess the association of UA trajectories with cardiac conduction block.ResultsWe categorized three observed discrete trajectories of UA during 2006–2012 period: low-stable, moderate-stable, and high-stable. Over a median follow-up of 6.19 years, we identified 1405 (2.09%) incident cardiac conduction block. Compared to those in the low-stable trajectory, the adjusted hazard ratios (HRs) (95% confidence interval [CI]) of cardiac conduction block in the moderate-stable and high-stable trajectory were 1.30 (1.16–1.47) and 1.86 (1.56–2.22), and HRs of atrioventricular block were 1.39 (1.12–1.72) and 2.90 (2.19–3.83), and HRs of bundle branch blocks were 1.27 (1.10–1.47) and 1.43 (1.13–1.79). Notably, although the average UA level in the moderate-stable UA trajectory group is within the normal range, the risk of cardiac conduction block has increased.ConclusionsThe moderate-stable and high-stable trajectories are associated with increased risk for new-onset cardiac conduction block. Monitoring UA trajectories may assist in identifying subpopulations at higher risk for cardiac conduction block.

Uric acid level in Chronic Kidney Disease patients and its association with other established CKD risk factors

Introduction: Chronic Kidney Disease (CKD) is a rising global health concern with increased cardiovascular risks. Hyperuricemia, linked to CKD and related conditions, warrants investigation. Objectives: This study examines the uric acid in different stages of CKD and the association between uric acid levels and established CKD risk factors. Methodology: A hospital-based prospective cross-sectional study was conducted at Birat Medical College Teaching Hospital from 10 June 2023 to 30 August 2023. We enrolled 90 patients with non-dialytic chronic kidney disease (CKD) by complete enumeration sampling method. Ethical approval was obtained from the institutional review committee of the college. Written informed consent was obtained from each participant. Data was collected by means of a self developed questionnaire. Blood samples were obtained for estimation of serum creatinine and uric acid level and recorded in Microsoft excel sheet and analyzed by using SPSS software version 23. Results: Hyperuricemia was seen in 33(36.7%) ranging from 3.5-12 mg/dl with an average uric acid level of 6.38 mg/dl and a standard deviation of 1.43 mg/dl of total 90 patients. The mean serum uric acid level was highest in stage 2 CKD which includes 6.88±2.10 ranging from 4.3-12 mg/dl. CKD patients with a history of alcohol intake had increased risk of hyperuricemia and it was statistically significant (p value 0.005). Different stages of CKD (p value: 0.70), age groups, (p value 0.17), gender(P value 0.082), diabetes(p value 0.954), hypertension(p value 0.364), other CVDs(p value 0.649)and anemia(p value 0.0602)had no statistical significant association with hyperuricemia. Conclusion: In conclusion, hyperuricemia prevalence was observed in CKD patients, with the highest levels in stage 2 CKD. Notably, alcohol intake significantly correlated with hyperuricemia, while other studied factors did not show significant associations.

Assessment of renal and cardiovascular risks in patients with type 2 diabetes when using non-steroidal mineralocorticoid receptor antagonists

Background. Given the proven excessive activation of the renin-angiotensin-aldosterone system and the clinical manifestations of hypertension, mostly of renal origin, there is a need to optimize antihypertensive therapy aimed at an active nephroprotection. The purpose of the study is to carry out a comprehensive assessment of kidney and heart risk factors in patients with type 2 diabetes mellitus and chronic kidney disease (CKD) and to justify the administration of non-steroidal mineralocorticoid receptor antagonists to these patients. Materials and methods. In a prospective cohort study, 88 patients with type 2 diabetes were examined: group 1 — estimated glomerular filtration rate (eGFR) < 60 ml/min/m2, group 2 — eGFR ≥ 60 ml/min/m2. eGFR was evaluated according to the CKD-EPI (Chronic Kidney Disease Epidemiology Colla­boration) formula based on serum creatinine. GFR category was defined according to the KDIGO (Kidney Disease: Improving Global Outcomes) criteria. The albumin-creatinine ratio was calcula­ted. The level of glycated hemoglobin (HbA1c) was assessed by the method of high-performance liquid chromatography. Aldosterone was evaluated by immunoenzymatic method. Results. In patients with eGFR < 60 ml/min/m2, the albumin-creatinine ratio in daily urine is statistically significantly higher compared to group 2. Patients with eGFR < 60 ml/min/m2 had an average uric acid level of 410.3 ± 98.8 μmol/l, which is statistically significantly higher than in those with eGFR ≥ 60 ml/min/m2 — 321.10 ± 74.54 μmol/l. A statistically significant correlation between the level of uric acid and markers of renal dysfunction was found only in patients with eGFR < 60 ml/min/m2. Aldosterone levels were higher in the first group. No statistical difference was found between the average value of HbA1c in the studied groups. Conclusions. Numerous factors of unfavorable prognosis regarding kidney and heart risks have been identified: hypertension, increased albumin-creatinine ratio and cholesterol, unsatisfactory compensation of diabetes, obesity. There is an increase in the frequency of resistant hypertension, hyperuricemia, and hyperaldosteronism in patients with decreased eGFR. In patients with diabetic kidney damage on the background of type 2 diabetes, the administration of finerenone, a non-steroidal mine­ralocorticoid receptor antagonist, at a dose of 10–20 mg/day is pathogenetically justified.

Effect of Candesartan Usage on Uric Acid Levels

Cardiovascular disease is caused by disorders of the heart and blood vessels. One of the risk factors for cardiovascular disease is hyperuricemia, which indicates a high uric acid level in the blood, namely ≥7.0 mg / dL in men and ≥6.0 mg/ dL in women. Candersatan is one of the main line therapies that are widely used in cardiovascular patients which in previous studies were known to affect uric acid levels. This study aims to determine the effect of the use of candersatan on uric acid levels in cardiovascular patients for 3 months. This study uses a cross-sectional study with a prospective approach that is by examining uric acid levels before and after three months using candersatan and analyzed using SPSS statistical test Paired test. Of the total samples that met in the inclusion and exclusion criteria were 19 patients, the results showed an increase in uric acid levels with a significance value of 0,012 (p = ≤0.05). So it can be concluded that the average uric acid level of patients before using candersatan was 5.44 mg / dL, and the average uric acid level after using candersatan for three months was 6.30 mg / dL which means that the used of 8 mg candersatan for three months had a significant effect on the increase in uric acid levels in cardiovascular patients.

Correlation between Uric Acid Levels and the Severity of Psoriasis Vulgaris Patients

Introduction: Psoriasis vulgaris (PV) is a recurrent chronic inflammatory skin disease characterized by erythematous, scaly, well-defined plaques with the greatest predilection, generally in the areas of the elbows, knees, scalp, and lower back. The psoriasis area and severity index (PASI) is one of the most widely used evaluation tools to determine the development of psoriasis vulgaris in a patient. Hyperuricemia is the dominant risk factor for PV when compared to other known risk factors, such as obesity or metabolic syndrome. This study aimed to determine whether there is a relationship between serum uric acid levels and the severity of PV based on the PASI score.
 Methods: Cross-sectional study with one-time sampling conducted from December 2021 to February 2022 in psoriasis vulgaris patients who came to the Dermatology and Venereology clinic at Dr. Moewardi General Hospital, Surakarta, Indonesia. All data were statistically analyzed using SPSS 26. Variables, including age, gender, disease duration, body mass index, and uric acid levels, were subjected to univariate analysis. Bivariate analysis was then followed by a parametric test. The p-value <0.05 was considered significant.
 Results: There were 36 patients during the study period. The average uric acid level was 6.0135, with an average PASI score of 10.6388. The relationship between uric acid levels and the severity of psoriasis vulgaris was found to be significant, with a value of p = 0.025.
 Conclusion: There is a significant relationship between uric acid levels and the severity of psoriasis vulgaris, where the higher the uric acid level, the more severe the severity of psoriasis vulgaris.

RELATIONSHIP OF HYPERURACEMIA WITH METABOLIC DISORDERS IN PATIENTS WITH ARTERIAL HYPERTENSION

Objective: To study the prevalence of hyperuremia and to study its role in development of metabolic disorders in patients with arterial hypertension (AH). Design and method: The study analyzed 188 case histories of patients with AH grades 1-3 (ESC/ESH, 2018). 109 women and 79 men were studied. Mean age 62.8±10.2 years. Hyperuricemia was established with an increase in the level of uric acid > 7 mg / dl in men, > 5.7 mg / dl in women. Results: Results: For analysis, patients were divided into 2 groups: the first group consisted of patients with hyperuricemia (n = 103), the second - patients with normal levels of uric acid (n = 85). The average level of uric acid in the 1st group was 7.44±1.33 mg/dl, and in the 2nd group - 5.06±0.98 mg/dl, p<0.00001. The compared groups were similar in terms of age, office SBP and DBP. Age: 62.7±10.51 vs 62.8±10.01 years, p = 0.95; SBP - 136.82±22.09 mm Hg. vs 132.98±24.4 mmHg, p = 0.26; DBP - 85.17±10.27 mm Hg. vs 84.27±10.71 mmHg, p = 0.56. The groups also did not differ in BMI and WC: BMI-32.96±5.84 kg/m2 vs 31.24±5.00 kg/m2 p = 0.44; OT-105.44±13.75 cm vs 102.76±12.06 cm, p = 0.16. It should be noted that patients with hyperuricemia had a significantly high level of MAU: 63.24±104.06 vs 39.33±36.42 mg/l, p = 0.044. Patients with hyperuricemia had more pronounced dyslipidemia. Thus, total cholesterol was significantly high in group 1: 198.31±49.41 mg/dl vs 181.75±49.1 mg/dl, p = 0.04, LDL cholesterol 111.83±42.46 mg/dl dl vs 100.56±37.99 mg/dl, p = 0.04. TG and HDL-C did not differ between the groups. TG: 223.39±130.76 vs 189.69±122.18 p = 0.057. HDL-C: 41.92±13.54 mg/dl vs 43.30±12.87 mg/dl, p = 0.48. In the group of patients with hyperuricemia, there was a significantly high level of glucose compared with patients with normal levels of uric acid: 9.71±04.35 mmol/l vs 6.51±3.06 mmol/l, p = 0.0001. The creatinine level was also high in patients with hyperuricemia: 98.45±36.75 μmol/l vs 85.06±17.21 μmol/l, p = 0.003. Conclusions: Hyperuricemia should be considered as an additional cardiovascular risk in hypertensive patients. Hyperuricemia is associated with severe dyslipidemia and elevated levels of glycemia and creatinine in hypertensive patients.

Associations Between Insulin Resistance Indexes and Hyperuricemia in Hypertensive Population

Objective To explore the relationship between insulin resistance (IR) indexes and hyperuricemia (HUA) among the people with hypertension. Methods From July to August in 2018,hypertension screening was carried out in Wuyuan county,Jiangxi province,and the data were collected through questionnaire survey,physical measurement,and biochemical test.Logistic regression was performed to analyze the relationship between HUA and IR indexes including metabolic score for IR (METS-IR),triglyceride-glucose (TyG) index,TyG-body mass index (BMI),TyG-waist circumference (WC),visceral adiposity index (VAI),triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C),and lipid accumulation product (LAP).The penalty spline method was used for the curve fitting between IR indexes and HUA.The area under the receiver operating characteristic curve (AUC) was employed to reveal the correlation between each index and HUA. Results The 14 220 hypertension patients included 6 713 males and 7 507 females,with the average age of (63.8±9.4) years old,the average uric acid level of (418.9±120.6) mmol/L,and the HUA detection rate of 44.4%.The HUA group had higher proportions of males,current drinking,current smoking,diabetes,and using antihypertensive drugs,older age,higher diastolic blood pressure,WC,BMI,homocysteine,total cholesterol,TG,low-density lipoprotein cholesterol,blood urea nitrogen,creatinine,aspartate aminotransferase,alanine aminotransferase,total protein,albumin,total bilirubin,direct bilirubin, METS-IR, TyG, TyG-BMI, TyG-WC, VAI, TG/HDL-C, and LAP, and lower systolic blood pressure and HDL-C than the normal uric acid group (all P<0.05).Multivariate Logistic regression showed that METS-IR (OR=1.049,95%CI=1.038-1.060, P<0.001), TyG (OR=1.639,95%CI=1.496-1.797, P<0.001), TyG-BMI (OR=1.008,95%CI=1.006-1.010, P<0.001), TyG-WC (OR=1.003,95%CI=1.002-1.004, P<0.001), lnVAI (OR=1.850, 95%CI=1.735-1.973, P<0.001), ln(TG/HDL-C) (OR=1.862,95%CI=1.692-2.048, P<0.001),and lnLAP (OR=1.503,95%CI=1.401-1.613,P<0.001) were associated with the risk of HUA.Curve fitting indicated that METS-IR,TyG,TYG-BMI,TYG-WC,lnVAI,ln(TG/HDL-C),and lnLAP were positively correlated with HUA (all P<0.001),and the AUC of TyG index was higher than that of other IR indexes (all P<0.05). Conclusion Increased IR indexes,especially TyG,were associated with the risk of HUA among people with hypertension.

Allopurinol

Allopurinol

Analysis Of Uric Acid Levels In Pre-Elderly Patients In Terms Of Coffee Drinking Behavior In The Work Area Of The Cikeusal Health Center, Serang Regency In 2022

The World Health Organization (WHO) states that hyperuricemia sufferers are increasing every year in the world. The Cikeusal Health Center in Serang Regency shows that cases of hyperuricemia are quite high, namely as many as 189 in 2020, increasing in 2021, namely 340, even in 2022 in the January-September period there were 208 cases. One of the pharmacological treatments in the treatment of hyperuricemia is coffee because it contains polyphenolic compounds. Purpose of Writing was to knowing the analysis of uric acid levels in pre-elderly patients in terms of coffee drinking behavior in the working area of the Cikeusal Health Center, Serang Regency, in 2022. Research Methods on this research is a quantitative analytic study with a cross sectional design. The sample in this study were pre-elderly patients who visited the Cikeusal Health Center in Serang Regency in August-October 2022 with a total of 81 respondents using a purposive sampling technique. The research instrument used questionnaires and observation sheets. The data is primary data analyzed using the one way ANOVA test which previously had been carried out the normality test with normal data distribution results. The results of univariate analysis revealed that the average uric acid level was 4.786, coffee drinking behavior was low, medium and high respectively 33.3% with an average of 21.07. The results of the bivariate analysis revealed that there was an effect of coffee drinking behavior on uric acid levels with a p value = 0.021. Coffee drinking behavior affects uric acid levels in pre-elderly patients. It is hoped that the community can carry out routine checks and maintain food intake, one of which is drinking coffee regularly between 1-2 times a day.

Plasmonic nanomaterials-based flexible strips for the SERS detection of gouty arthritis.

Flexible biochips that enable sensitive detection and simultaneous quantification of biomarkers are of great importance in the field of point-of-care testing. Recently, surface-enhanced Raman scattering (SERS)-based flexible biochips have attracted a great deal of research attention for disease detection due to their rapid, sensitive, and noninvasive sensing abilities. Phenomenal progress in the synthesis of structure-controlled plasmonic nanomaterials has made SERS a powerful sensing platform for disease diagnosis and trace detection. Here, we demonstrate flexible plasmonic biochips for the SERS-based detection of uric acid (UA). Flexible strips exhibited excellent sensing performance with a detection limit of around 10 μM of UA, which is lower than the average level of UA in tears. This rapid and sensitive detection method enables the noninvasive diagnosis of gouty arthritis.

The elevated visceral adiposity index increases the risk of hyperuricemia in Chinese hypertensive patients: A cross-sectional study.

Uncertainty still remained about the relationship between visceral adiposity index (VAI) and hyperuricemia. The aim of this study was to investigate whether VAI was an independent risk factor for hyperuricemia in hypertensive Chinese patients. A cross-sectional study including 13176 hypertensive participants (6478 males) recruited from Wuyuan County, Jiangxi province, was conducted. All patients received anthropometric measurements, completed questionnaires and provided blood samples for biochemical testing. VAI was calculated by waist circumference, BMI, triglyceride and high-density lipoprotein cholesterol. Hyperuricemia was defined as serum uric acid ≥ 7 mg/dL in men and ≥ 6 mg/dL in women. Overall, the average level of uric acid was 7.8 ± 2.0 mg/dL in males and 6.34 ± 1.78 in females and prevalence of hyperuricemia was 61.4% and 51.30%, respectively. In multivariate logistic regression analysis, the risk of hyperuricemia increased 1.77 times and 1.88 times with the increase of ln VAI in males (OR:1.77, 95% CI: 1.62, 1.94) and females (OR:1.88, 95% CI: 1.73, 2.04). For males, compared to quartile 1, the risk of hyperuricemia in the second, third and the forth quartile of visceral adiposity index were 1.34 (95% CI: 1.14, 1.57),1.82(95% CI: 1.54, 2.14) and 2.97 (95% CI: 2.48, 3.57). For females, compared to quartile 1, the risk of hyperuricemia in the second, third and the forth quartile of visceral adiposity index were 1.48 (95% CI: 1.28, 1.72), 1.99 (95% CI: 1.71, 2.32) and 2.92 (95% CI: 2.50, 3.42). This study found that VAI was an independent risk factor for hyperuricemia among hypertensive patients, which may provide some strategies for reducing the level of uric acid.

Efek Obat Antituberkulosis Fase Intensif dan Konsumsi Purin Terhadap Kadar Asam Urat Pasien Tuberkulosis

ABSTRACT A high prevalence of TB requires serious treatment with Anti-Tuberculosis Therapy, but the side effects can gain uric acid levels. This study aimed to analyze the effects of intensive phase therapy and high purine consumption patterns with uric acid levels in TB patients with Anti-Tuberculosis Therapy. This research was an analytic study using a prospective cohort design. The population was all tuberculosis patients who received Anti-Tuberculosis Therapy at several Public Health Centers in Samarinda. The sampling technique used consecutive sampling approach. The respondents were selected according to the inclusion criteria and had signed the informed consent. Furthermore, the venous blood was measured to know the levels of the uric acid pre-test. The measurements of uric acid levels post-test were carried out after undergoing Anti-Tuberculosis Therapy for 2 months and filling out the FFQ questionnaire to determine the patterns of high purine consumption. The collected data was analyzed using a t-paired and a one-way anova test. T-Paired test results exhibited that there were increasing trend in the average uric acid levels after following Anti-Tuberculosis Therapy in an intensive phase of 2.53 mg / dL (39.78%) with p-value &lt;0.001. Besides, the one way anova test results showed that the average difference in uric acid levels in respondents who consumed high purine 4-6 times/week was 3.16 mg / dL and was higher than respondents who never consumed high purine or those who consumed high purine 1-3 times/week with a p-value &lt;0.001. An average increase in uric acid levels in TB patients after undergoing the intensive phase of Anti-Tuberculosis Therapy for 2 months with a pyrazinamide and ethambutol regimen and an increase in uric acid levels was higher compared to respondents who consumed high purine. Keywords: uric acid level, high purine consumption, intensive phase

Pengaruh Konsumsi Tuak Terhadap Kadar Asam Urat Pada Masyarakat Dewasa di Desa Jagaraga Timur

Tuak is a type of alcoholic drink made from palm sugar. Excessive consumption of tuak continuously can increase the levels of uric acid in the body. Uric acid is the end product of purine metabolism. This study aimed to determine the effect of tuak consumption of uric acid levels in the adult community in East Jagaraga Village. This research is an analytical observation using a cross-sectional approach. The sampling technique was a simple random sampling of 48 people, namely 24 adults that consumed tuak and 24 adults who did not consume tuak. Data analysis in SPSS used an independent sample t-test. The average uric acid levels in 24 respondents that consumed and did not consume tuak were 7.46 mg/dl and 4.92 mg/dl, respectively. The results show that there is an effect of tuak consumption uric acid levels in the adult community in the East Jagaraga Village, this is shown in a probability value (p = 0.000) &lt;0.05 then Ho is rejected and Ha is accepted. From these results, it can be concluded that the consumption of tuak in the long term affects increasing uric acid levels.

Gambaran Kadar Asam Urat Pada Pasien Gagal Ginjal

Uric acid or urine acid is a product of purine nucleic acid catabolism. Uric acid is produced from within the body (genetic) and from outside (food consumed). Uric acid is measured to assess purine metabolism abnormalities, to confirm the diagnosis and monitoring of treatment, and to detect abnormalities in kidney function. In this situation, the results of purine metabolism (uric acid) that should be excreted out of the body through the kidneys do not occur, so that uric acid in the blood will increase over time. Kidney failure disease kidney organ function has decreased so that eventually unable to work as a filter, dispose of body electrolytes, and maintain fluid and chemical balance in the blood or urine production. This study aims to determine uric acid levels and the percentage of uric acid levels that are outside the normal range and the relationship between hemodialysis time and uric acid levels in patients with kidney failure. The research method used is the descriptive method and the examination method uses the uricase enzymatic method. For data analysis using the SPSS Bivariate test program with Spearmen's Rank test with a sig value of 0.608 which was carried out on 32 samples of serum from hemodialysis patients at random. The results of this study showed that the average uric acid level was 7.1 mg/dL, while normal uric acid levels were 2.7 mg/dL, and the highest was 10.2 mg/dL. Uric acid levels that showed normal results were 12 respondents or 37.5% and increased results were 20 respondents or 62.5%. There is no relationship between the length of hemodialysis time and uric acid levels in patients with kidney failure.

THE EFFECT OF GIVING BOILED WATER OF MAHKOTA DEWA FRUIT ON URIC ACID LEVELS IN MENOPAUSAL WOMEN

Menopause is a normal change that occurs in a woman's life when her menstrual period stops. The average age reaches 48-60 years. A woman has reached menopause if she has not had her periods for 12 consecutive months, and there are no other reasons for the changes that occur during menopause. The number of follicles experiencing atresia is increasing, until one day there are no longer enough follicles, the production of estrogen decreases and menstruation does not occur again which ends with menopause. The purpose of this study was to determine the effect of giving boiled water of Mahkota Dewa fruit on uric acid levels in menopausal women at the Tamalanrea Jaya Public Health Center Makassar. This research is quantitative with a pre-experimental design using the One Group Prettest-Posttest Design. The population in this study were 57 respondents with a sample of 20 respondents. In this study using the Paired Sample T Test. The results showed that the average level of uric acid before and after being given boiled water from the crown of the god was 4,000, Std. Deviation 6.459, S.td Error Mean 2.103 with 95% CI = 1.785-12,215 with p value = 0.000. The conclusion of this study is that there is an effect of giving boiled water of the crown of the gods on uric acid levels in postmenopausal women at the Tamalanrea Jaya Health Center Makassar. It is recommended to the Tamalanrea Jaya Makassar Public Health Center to be used as a reference for further researchers about the benefits of boiled water from the crown of the god on uric acid levels in postmenopausal women.

Pengaruh Konsumsi Jus Nanas Terhadap Kadar Asam Urat Pada Wanita Menopause

Abstract. Gout often attacks people over the age of 30, this is because at that age the declining esterogenous levels can cause uric acid levels in the blood to increase. High uric acid levels can be overcome with a variety of treatments including nonpharmacological treatment in the form of giving pineapple juice. Prevention that can be done to keep uric acid levels normal is by limiting purine foods, choosing low-purine foods, avoiding taking drugs, and taking vitamin C supplements including consuming pineapple juice. The purpose of this study was to determine uric acid levels before and after giving pineapple juice and to determine the difference in results before and after giving pineapple juice on uric acid levels in menopausal women. The research method was pre experiment and the method of examining uric acid levels using the POCT method. The population in the study were 25 menopausal women aged 45-55 years in RW 3 Kaliwadas Village, Cirebon Regency. The sample in the study was 22 menopausal women, with the sampling technique using purposive sampling. Data from the examination of uric acid levels before and after the administration of pineapple juice obtained the results of 21 samples that experienced a decrease (95.45%) and 1 sample that experienced an increase (4.45%) with an average uric acid level before 5.6 mg/dL with the highest level of 8.4 mg/dL and the lowest level of 4.7 mg/dL and the average after 5.3 mg/dL with the highest level of 8.4 mg/dL and the lowest level of 3.7 mg/dL. The research data were analyzed using a normality test and paired sample T-test obtained Sig. (2-tailed) 0.000 &lt;0.005. based on this study it can be concluded that there is an influence on uric acid levels before and after being given pineapple juice.

Сечокам'яна хвороба як наслідок вторинної гіперурикемії у пацієнтів з діабетичним ураженням нирок

Urolithiasis is currently one of the most pressing problems of modern urology and medicine in general. The pathogenesis of urolithiasis is multifactorial and caused by various metabolic disorders, in particular carbohydrate, the main manifestation of which is diabetes mellitus. In connection with the above, a comparative approach to the study of metabolic disorders in patients with diabetic kidney damage, in particular hyperuricemia, is relevant in order to identify possible causes of lithogenesis. The purpose of the study is to study the effect of secondary hyperuricemia on the formation of urinary stones in patients with diabetic kidney damage, compared with non-diabetic nephropathies. Materials and methods. The study included 59 patients with chronic kidney disease, including 27 with diabetic nephropathy and 32 with non-diabetic nephropathy. All patients underwent a comprehensive clinical and laboratory study, which included glycosylated hemoglobin, glycemic profile, lipid complex, C-reactive protein, serum creatinine, urea, electrolytes, uric acid, uric acid clearance, glomerular filtration rate, and ultrasound examination of the urinary system. Results and discussion. Urolithiasis was detected in 70.3 % patients with diabetic kidney disease and in 29.6% patients with non-diabetic pathology. The stones had a renal localization: pelvic stones occurred in 38.9% patients, stones in calyces – in 61.1% patients. When assessing the biochemical parameters, the average level of uric acid in the blood serum of patients with diabetes mellitus significantly exceeded the same indicator in the group of patients with non-diabetic pathology. Also, the level of hyperuricemia was higher in diabetic patients with a glycosylated hemoglobin content of more than 8.5%, compared with patients with an HbA1 concentration of less than 7.5%. In patients of both groups compared with serum uric acid concentrations exceeding the level of 498.5 mmol/l in men and 384.2 mmol/L in women, there was a progression of arterial hypertension. In patients with diabetic nephropathy, there was a significant increase in the level of cholesterol, low-density lipoproteins and triglycerides, which provided an increase in the value of the atherogenicity index to 5.7±1.2. Conclusion. In patients with diabetic kidney damage, there are prerequisites for the development of urolithiasis, due to the development of a number of metabolic disorders that affect kidney function and the composition of urine. The key links in the pathogenesis of more frequent development of urolithiasis in this category of patients are secondary hyperuricemia, as well as disorders of carbohydrate and lipid metabolism in the form of hyperglycemia and hyperlipidemia

Association of blood uric acid with the duration of diabetes in type 2 diabetics: A pilot study

Diabetes Mellitus is the most common non-communicable disease which is vastly conquering both the developed &amp; developing countries of the world. Hypothesis: serum uric acid plays as an independent risk factor for the development of type 2 diabetes. Studies revealing the clearance of uric acid reduced with insulin resistance are few in numbers. A positive correlation between uric acid and glucose levels leads to the development of type 2 diabetes. To correlate the levels of blood uric acid with the duration of diabetes in type 2 diabetics. Fifteen type 2 diabetes patients with no history of any complications and other systemic organ &amp; metabolic disorders like gout &amp; obesity randomly selected for this cross-sectional study. A biochemical investigation, like the Uricase method employed for fasting serum uric acid levels estimation. Statistical analysis by the Pearson correlation test used. Positive correlation of serum uric acid with the duration of diabetes in type 2 diabetic patients found to be statistically significant (r = +0.6, p &amp;#60; 0.05). Out of fifteen, eleven of them were suffering from hyperuricemia (73%). Average uric acid level elevated from 6.88 ± 0.95 in people with the duration of diabetes 2 to 6 years to 7.61 ± 3.16 in people with the duration of diabetes 7 to 10 years. The positive association of fasting serum uric acid with the duration of type 2 diabetes suggests that uric acid acts as an independent biochemical marker for prognosis of the type 2 diabetes. Drugs that reduce the uric acid levels may be useful in avoiding the development and prognosis of insulin resistance that causes type 2 diabetes and other complications.