* Abbreviation: COVID-19 — : coronavirus disease 2019 Each year, before 2020, millions of children contracted influenza virus.1 From 2020 to 2021, protective measures to prevent the spread of coronavirus disease 2019 (COVID-19), such as mask wearing, social distancing, and frequent hand-washing, likely protected children from other infectiousdiseases, including seasonal influenza.2 However, as COVID-19 preventive measures begin to abate and children return to school and normal activities outside the home, the seasonal influenza will again be a threat to young children nationally. Children under 18 years of age are twice as likely to develop symptoms as adults over age 65 years, and those under 4 years of age are over 3 times as likely.1 Young children, especially those under 5 years old, are at the highest risk for severe illness and death from influenza.1,3 Children are also key drivers of transmission, on average spreading influenza to multiple age groups and for longer periods than adults.4 Influenza vaccination is still the best method of preventing influenza and its associated complications. Influenza vaccine should be given to children starting at age 6 months, and 2 doses of influenza vaccine, administered 28 days apart, should be given to a child under age 9 years if they have not previously received 2 doses during an influenza season. Previous studies have shown the importance of both doses, especially in vaccine-naive children. For example, in vaccine-naive children aged 2 years or younger, vaccine effectiveness is cut … Address correspondence to Melissa S. Stockwell, MD, MPH, Division of Child and Adolescent Health, Department of Pediatrics, Vagelos College of Physicians & Surgeons, Columbia University, 622 W 168th St, VC 417, New York, NY 10032. E-mail: mss2112{at}cumc.columbia.edu