The aim of this study was to investigate the influence of prolonged aerobic exercise on cardiac, muscular and renal inflammatory markers in a group of trained obese men. Seventeen men (aged 40 ± 6years; body mass index [BMI] 31.3 ± 2.8kgm-2, maximal oxygen uptake [V'O2max] 41.5 ± 5.6mlkg-1min-1) ran a half, 30km, or full marathon. Troponin I (cTnI), the n-terminal creatine kinase-myocardial band (CK-MB), pro b-type natriuretic peptide (NT-proBNP), lactate dehydrogenase (LDH), myoglobin, creatinine (CREA) and the estimated glomerular filtration rate (eGFR)were measured before (T0), immediately after (T1) and 3days after the race (T2). The concentrations of cTnI, myoglobin, LDH, CK-MB and CREA significantly increased (P < 0.05), whereas eGRF decreased at T1 (P < 0.05). All the above parameters returned to baseline at T2, except for eGFR, which remained lower than that at T0 (P < 0.05). A positive association was observed between ΔCK-MB (%) and the time spent in Zone 3 during the race (R = 0.686, P = 0.014). The Δmyoglobin (%) was positively correlated with race time, race mean speed and time in Zone 3 (R = 0.574-0.862, P < 0.05). The ∆CREA values were moderately correlated with the race mean HRMAX (%) and time spent in Zone 3 (%) (R = 0.514-0.610; P = 0.05). The ∆eGRF values were moderately inversely correlated with the time spent in Zone 3 (%) (R = - 0.627; P < 0.05). Changes in cardiac, muscular and renal inflammatory markers in trained men with obesity are consistent with those described in the literature in normal-weight individuals. Finally, running parameters, such as running time, average running intensity and time in Zone 3 appear to be responsible for the changes in cardiac, muscular and renal function markers after long-distance running.
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