Average Pressure Research Articles

Hypertension and its correlation with autonomic nervous system dysfunction, heart rate variability and chronic inflammation

Objective This study investigates the relationship between hypertension, dysregulation of the autonomic nervous system, heart rate variability (HRV), and chronic inflammation. Methods We analysed a cohort of 50 hypertensive patients treated at the affiliated Hospital of Jianghan University. The average systolic and diastolic blood pressures (BPs) in this group were 155.26 and 95.32 mmHg, respectively. A control group of 50 healthy volunteers, undergoing routine physical examinations at the same hospital, was also analysed. Results The average systolic BP of the control group was 115.64 ± 10.27 mmHg, and the average diastolic BP was 75.33 ± 8.25 mmHg. In contrast, the experimental group exhibited an average systolic BP of 155.26 ± 20.13 mmHg and an average diastolic BP of 95.32 ± 12.16 mmHg. Both systolic and diastolic BPs were significantly higher in the hypertensive group (p < 0.05). The experimental group also demonstrated reduced HRV and skin conductance response, alongside increased BP variability (BPV), urinary epinephrine levels and prolonged pupillary light reaction time compared to controls (p < 0.05). Notably, Standard Deviation of Normal to Normal Intervals (SDNN) and Root Mean Square of Successive Differences (RMSSD) values were significantly lower in the experimental group (p < 0.05). Furthermore, levels of inflammatory markers such as CRP, TNF-α, IL-6 and IL-1β were markedly elevated in hypertensive patients (p < 0.05). Negative correlations were observed between systolic and diastolic BP with HRV metrics, while positive correlations were found between BP and BPV as well as urinary adrenaline levels. Conclusions The findings indicate that hypertension is closely associated with autonomic nervous system dysfunction, reduced HRV and increased chronic inflammation. A comprehensive approach to hypertension management should integrate these interrelated physiological and pathological mechanisms, with potential therapeutic interventions targeting autonomic function and inflammatory states.

Effects of field activities by age of 119 emergency response team on the blood pressure, pulse, respiration, and quality of cardiopulmonary resuscitation

This study analyzed the physical changes according to age and the quality of cardiopulmonary resuscitation through experiments by 119 EMT in transporting equipment at the first aid site and performing post-cardiopulmonary resuscitation. In all ages, cardiopulmonary resuscitation was performed without physical load and CPR was performed after moving the equipment, first, the pulse was significantly increased, and the average pulse was measured higher than in other higher age groups under the age of 30. Second, respiratory changes were significantly increased, and average breathing was measured higher than in other higher age groups when CPR was performed after wearing personal protective equipment and moving the equipment. Third, as for changes in blood pressure, all blood pressure rose, and the average blood pressure in the 40s and older was measured higher than that of the younger age. Fourth, in the quality change of cardiopulmonary resuscitation, the pressure rate was found to have a statistically significant difference in those under 30, 30 to 34, and 35 to 39 years of age, and it was measured that the speed was maintained without change in those over 40. Finally, there was a statistically significant difference in pressure depth between those under 30 and those under 35-39 years old, and the average depth was measured deeper than other higher age groups, so it is necessary to develop differentiated education and training methods at those under 30 years of relatively little experience.

The influence of lumbar vertebra and cage related factors on cage-endplate contact after lumbar interbody fusion: An in-vitro experimental study

Lumbar interbody fusion (LIF) using interbody cages is an established treatment for lumbar degenerative disc disease, but fusion results are known to be affected by risk factors such as bone mineral density (BMD), endplate geometry and cage position. At present, direct measurement of endplate-cage contact variables that affect LIF have not been fully identified. The aim of this study was to use cadaveric experiments to investigate the dependency between BMD, endplate geometry, cage parameters like type, orientation, position, and contact variables like stress and area. One vertebral body specimen from each of the five lumbar positions was harvested from five male donors. The lower half of each vertebra was potted and placed in a material testing machine (Instron 8874). A spinal cage was clamped to the machine then lowered to bring it into contact against the superior endplate. A lockable ball-joint was used to rotate the cage such that its inferior surface was congruent with the local endplate surface. A pressure sensor (Tekscan) was placed between the cage and endplate to record contact area and the peak and average contact pressures. Axial compression of 400 N was performed for five positions using a straight cage, and in one anterior position using a curved cage. The linear mixed model was utilised to perform data analyses for experimental results with statistical significance set at p < 0.05. The results indicated two trends toward significance for contact area, one for volumetric BMD (vBMD) of the vertebra (p = 0.081), and another for predicted contact area (p = 0.057). Peak contact pressure correlated significantly with vBMD (p = 0.041), and there was a trend between average contact pressure and lateral position of cage (p = 0.051). In addition, predicted contact area correlated significantly with cage orientation (p < 0.001). These results indicated that high vBMD of vertebra and a medially positioned cage led to higher contact pressures. Logically, low vBMD of vertebra and transverse cage orientation increased the contact area between the cage and endplate. In conclusion, the study identified significant influence of vBMD of vertebra, cage position and orientation on cage-endplate contact which may help to inform cage selection and design for LIF.

A graph theory-based modelling method for multi-splitting-merging-channel refrigerant-cooled evaporator in battery thermal management

A multi-splitting-merging-channel refrigerant-cooled evaporator can provide non-uniform cooling capacity distribution to match a non-uniform distributed heat flux produced by a battery by properly arranged hierarchical refrigerant channel network, however the design of the refrigerant channels is extremely complex. The purpose of this study is to present a model to support the design of a multi-splitting-merging-channel refrigerant-cooled evaporator, and the model should have the functions of describing various channel network, predicting the refrigerant flow distribution in splitting and merging channels, and accurately presenting temperature distribution at unevenly distributed heat flux. In the model, the distributed parameter modelling approach is applied for predicting the thermal performance distribution; arbitrary kinds of control volumes are normalized into five standard types according to channel structures; the refrigerant flows with multiple splitting and merging are described by the calculation sequences of control volumes, which are generated based on the graph theory. Model validations are done on a small sized and a large sized evaporator samples by comparing the simulated results with the experiment data. It is shown show that, the average temperature deviations of the small sized and the large sized evaporator samples are 1.0 °C and 0.9 °C, respectively while their average pressure drop deviations are 2.8% and 2.1%, respectively. The validation result indicates that the accuracy of the proposed model is acceptable for engineering application.

Study on the Damage Characteristics of Wheat Kernels under Continuous Compression Conditions.

Peeling wheat yields higher-quality flour. During processing in a flaking machine, wheat kernels undergo continuous compression within the machine's chamber. As this compression persists, damage to the kernels intensifies and accumulates, eventually leading to kernel breakage. To study the damage characteristics of wheat kernels during peeling, this study established a continuous damage model based on Hertzian contact theory and continuous damage theory. The model's accuracy was validated through experiments, culminating in the calculation of critical parameters for wheat peeling. This study focused on different wheat varieties (Ningmai 22 and Jichun 1) and kernel sizes (the thicknesses of the small, medium, and large kernels were standardized as follows: Ningmai 22-2.67 ± 0.07 mm, 2.81 ± 0.07 mm, and 2.95 ± 0.07 mm; Jichun 1-2.98 ± 0.11 mm, 3.20 ± 0.11 mm, and 3.42 ± 0.11 mm). Continuous compression tests were conducted using a mass spectrometer, and critical damage parameters were analyzed and calculated by integrating the theoretical model with experimental data. The test results showed that the average maximum crushing force (Fc) for small, medium, and large-sized kernels of Ningmai 22 was 96.71 ± 2.27 N, 110.17 ± 2.68 N, and 128.41 ± 2.85 N, respectively. The average maximum crushing deformation (αc) was 0.65 ± 0.08 mm, 0.68 ± 0.13 mm, and 0.77 ± 0.17 mm, respectively. The average elastic-plastic critical pressure (Fs) was 50.21 N, 60.13 N, and 59.08 N, respectively, and the average critical values of elastic-plastic deformation (αs) were 0.37 mm, 0.38 mm, and 0.39 mm, respectively. For Jichun 1, the average maximum crushing force (Fc) for small-, medium-, and large-sized kernels was 113.34 ± 3.15 N, 125.28 ± 3.64 N, and 136.15 ± 3.29 N, respectively. The average maximum crushing deformation (αc) was 0.75 ± 0.11 mm, 0.83 ± 0.15 mm, and 0.88 ± 0.18 mm, respectively. The average elastic-plastic critical pressure (Fs) was 58.11 N, 64.17 N, and 85.05 N, respectively, and the average critical values of elastic-plastic deformation (αs) were 0.45 mm, 0.47 mm, and 0.52 mm, respectively. The test results indicated that during mechanical compression, if the deformation is less than αs, the continued application of the compression load will not result in kernel crushing. However, if the deformation exceeds αs, continued compression will lead to kernel crushing, with the required number of compressions decreasing as the deformation increases. If the deformation surpasses αc, a single compression load is sufficient to cause kernel crushing. Since smaller wheat kernels are more susceptible to breakage during processing, the peeling pressure (F) within the chamber should be controlled to remain below the average elastic-plastic critical pressure (Fs) of small-sized wheat kernels. Additionally, the kernel deformation (α) induced by the flow rate and loading in the chamber should be kept below the average elastic-plastic critical deformation (αs) of small-sized wheat kernels. This paper provides a theoretical foundation for the structural design and optimization of processing parameters for wheat peeling machines.

Experimental investigation of non-uniform heating effect on flow and heat transfer of supercritical carbon dioxide:An application to solar parabolic trough collector

In order to reduce the carbon dioxide emission, the supercritical carbon dioxide (sCO2) Brayton cycle is a good choice to convert solar energy into power using solar parabolic trough collectors (PTCs). Because the earth rotation induced non-uniform flux distribution threatens the safe operation of absorber tubes, we investigate the flow and heat transfer of sCO2 in a horizontal tube under non-uniform heating, with the mass fluxes, average heat fluxes and pressures in the ranges of (397–1244) kg/m2s, (99–413) kW/m2, and (7.5–15.7) MPa, respectively. On the contrary to the classical treatment of supercritical fluid (SCF), SCF is treated in a multiphase framework. It is found that, compared with the sCO2 heat transfer in horizontal tubes under uniform heating, the non-uniform heating not only enhances heat transfer, but also increases friction factors. Besides, the non-uniform heating weakens the stratification effect, but the difference of heat transfer between the top and bottom generatrixes cannot be completed eliminated. It is observed that the larger vapor-like-layer thicknesses on tube walls may switch the sCO2 heat transfer from normal heat transfer (NHT) to heat transfer deterioration (HTD). Three heat transfer mechanisms are commented by using the dimensionless numbers regarding the pseudo-boiling in supercritical pressures.

Modeling of Drain Consolidation in the Quick Triaxial Test and Its Analytical Solution

ABSTRACTSand columns have been widely used to accelerate drainage and then improving the mechanical properties of soft soil foundations. The sand column has also been introduced into the triaxial test by researchers, in the center of the cylindrical specimen, to greatly accelerate drainage and consolidation process. The objective of this paper is to evaluate the consolidation properties of the triaxial cylindrical specimen considering the presence of a sand column, and then to propose a consolidation model that simulates the consolidation process of the triaxial test. The consolidation equations were derived considering the drainage of the specimen with a sand column composed of both vertical and double‐radial flows. Then the analytical solution of the model was obtained based on specific initial and boundary conditions. The comparison between the consolidation model and the laboratory tests yielded highly consistent. The case study demonstrated that the proposed consolidation model accurately simulates the evolution of average pore pressure and degree of consolidation in triaxial specimens containing a sand column. The studies on the consolidation parameters showed that there were different effects on the drainage rate for the diameter of specimen, the permeability coefficients of specimen and sand column, as well as the radius of the sand column.

Unattended versus conventional blood pressure measurements in hospitalized hypertensive patients.

This study aims to compare the differences between unattended and conventional blood pressure measurements in hospitalized hypertensive patients. In fall of 2019, hypertensive patients at Ruijin Hospital underwent two rounds of unattended and conventional (nurse-monitored) blood pressure measurement. Both rounds used the same electronic blood pressure monitor with measurements taken three times, 30 s apart. Comparison was made using intra-class correlation coefficients, Bland-Altman plots, paired t-tests, etc. Among the 92 subjects in the study, the median age was 50 years old, with women accounting for 33.7%. Among the subjects, the median duration of hypertension was 8.0 years. The prevalence of diabetes, coronary heart disease, and stroke were 26.1%, 5.4%, and 6.5%, respectively. Whether unattended or conventional measurements were taken first, the average blood pressure measured first was slightly higher than the one measured later, but the difference was within 1-2 mmHg. Except that the average DBP during the round of conventional blood pressure measurements was significantly reduced by 1.6 mmHg compared to the conventional DBP, there were no other significant differences. Subgroup analysis by age, gender, BMI, and diabetes showed no significant difference in blood pressure measurement results between unattended and conventional methods. No significant difference was observed between unattended and conventional methods of blood pressure measurement in hospitalized hypertensive patients. Unattended blood pressure measurement can be adopted as the current standard for blood pressure management in hospitalized patients.

Effect of perioperative management on early graft function in living donor paediatric kidney transplantation

Abstract Background Paediatric kidney transplantation has an increased risk of surgical and vascular complications, with intensive care monitoring required postoperatively. This study aimed to determine if perioperative management affects early graft function in living donor paediatric kidney transplantation. Methods Clinical data was extracted from the electronic medical record for living donor kidney transplants at two paediatric centres covering the state of New South Wales (NSW), Australia from 2009 to 2021. Estimated glomerular filtration rate (eGFR) of 7 days and 1-month post-transplant were calculated as measures of early graft function. Results Thirty-nine eligible patients (female n (%) 13 (33%)) with a median (IQR) age of 6 (3–9) years and pre-transplant eGFR of 7 (6–10) mL/min/1.73 m2 were analysed. Mean (SD) central venous pressure (CVP) after revascularisation was 11 (4) mmHg. Intraoperatively, mean volume of fluid administered was 84 (39) mL/kg, and 34 (87%) patients received vasoactive agents. Average systolic blood pressure (BP) in the first 24-h post-transplant was 117 (12) mmHg. Postoperatively, median volume of fluid administered in the first 24 h was 224 (159–313) mL/kg, and 17 (44%) patients received vasoactive agents. Median eGFR 7 days and 1-month post-transplant were 115 (79–148) and 103 (83–115) mL/min/1.73 m2, respectively. Linear regression analyses demonstrated that after adjusting for age, the average CVP after revascularisation and average systolic BP in the first 24-h post-transplant were not associated with eGFR in the first month post-transplant. Conclusions Targeted intraoperative and postoperative fluid and haemodynamic characteristics were achieved but did not correlate with early graft function. Graphical Abstract

Prediction of Soil Temperature in Wheat Field Using Machine Learning Models

ABSTRACT Wheat is a very vital cereal crop in the development of a nation’s economy and agricultural sector. A crucial element that profoundly affects the growth and productivity of wheat is the soil temperature. As an insulating layer, straw mulch controls the soil temperature. Field measurement of the soil temperature is time-consuming and costly; therefore, the present study investigates the applicability of random forest (RF), support vector machine (SVM) and generalized regression neural network (GRNN) models for estimating soil temperature in wheat fields covered with straw mulch using meteorological, soil cover and agronomical parameters. A field study was conducted on the wheat cultivar with two soil cover treatments for measuring the soil temperature at three depths (5, 50 and 80 cm). Soil plant analysis development value; soil cover and depth; daily meteorological data such as average air temperature, average relative humidity, sunshine hours and vapor pressure were used as inputs for machine learning models in training and testing. Statistical performance indicators showed applicability of three models with a root mean square error (RMSE) ranging from 0.245–0.595°C, 0.867–0.886°C and 0.557–0.812°C, Nash-Sutcliffe efficiency (NSE) ranging from 0.917–0.987, 0.823–0.836 and 0.804–0.935 and Lin’s concordance correlation coefficient (CCC) ranging from 0.949–0.991, 0.887–0.897 and 0.881–0.957 for the RF, SVM and GRNN, respectively. Results indicated better performance of the RF model for predicting the soil temperature at different depths in the case of both crop and soil cover conditions. Also, the uncertainty analysis indicated the better performance of RF with R-factor and P-factor value of 0.40 and 0.84, respectively.

A Reduced Resistance, Concentric-Gated Artificial Membrane Lung for Pediatric End-Stage Lung Failure.

The goal of the low-resistance pediatric artificial lung (PAL-LR) is to serve as a pumpless bridge-to-transplant device for children with end-stage lung failure. The PAL-LR doubles the exposed fiber length of the previous PAL design. In vitro and in vivo studies tested hemocompatibility, device flow, gas exchange and pressure drop performance. For in vitro tests, average rated blood flow (outlet SO2 of 95%) was 2.56 ± 0.93 L/min with a pressure drop of 25.88 ± 0.90 mm Hg. At the targeted pediatric flow rate of 1 L/min, the pressure drop was 8.6 mm Hg compared with 25 mm Hg of the PAL. At rated flow, the average O2 and CO2 transfer rates were 101.75 ± 10.81 and 77.93 ± 8.40 mL/min, respectively. The average maximum O2 and CO2 exchange efficiencies were 215.75 ± 22.93 and 176.99 ± 8.40 mL/(min m2), respectively. In vivo tests revealed an average outlet SO2 of 100%, and average pressure drop of 2 ± 0 mm Hg for a blood flow of 1.07 ± 0.02 L/min. Having a lower resistance, the PAL-LR is a promising step closer to a pumpless artificial membrane lung that alleviates right ventricular strain associated with idiopathic pulmonary hypertension.

Effectiveness of Acupressure Therapy in Reducing Blood Pressure Hypertension sufferers

Hypertension is a disease that causes complications in sufferers, thereby reducing the sufferer's quality of life. Increased blood pressure in hypertension sufferers can be controlled with pharmacological and non-pharmacological therapy, one of which is using acupressure therapy. This study aims to determine the effectiveness of providing acupressure therapy in reducing blood pressure for hypertension sufferers in the Bukit Raya Village Sub-district Health Center Work Area, East Lampung. This research design is quantitative analytical with a Quasi-Experimental approach using a one group pretest and posttest design. The results of the research conducted showed that the average systolic blood pressure before acupuncture therapy was 168 with a standard deviation of 26.943. After therapy the average blood pressure value decreased to 122 with a standard deviation of 3.535. Meanwhile, the average diastolic blood pressure before acupressure therapy was 103 with a standard deviation of 11.18. After therapy the average blood pressure value decreased to 71 with a standard deviation of 2.204. Seeing the effectiveness of acupressure therapy in lowering blood pressure in hypertensive patients, this therapy can be applied as a non-pharmacological treatment for patients who experience high blood pressure. Keywords: Acupressure, blood pressure, hypertension

Clinical correlates of medication adherence in individuals with bipolar disorder and comorbid hypertension.

Individuals with bipolar disorder (BD) have high rates of suboptimal medication adherence, medical illness, and premature mortality, largely from cardiovascular causes. This analysis examined the association between adherence to antihypertensive and BD medications and clinical symptoms in patients with BD and comorbid hypertension (HTN) from an ongoing trial to optimize adherence. Inclusion criteria were a BD diagnosis, treatment with antihypertensives, adherence challenges, and poorly controlled HTN. Adherence was measured via self-report using the Tablets Routine Questionnaire and using eCAP, an electronic pillcap which captures openings. Average systolic blood pressure (SBP) was calculated from 12 readings over 1week. The Montgomery-Asberg Depression Rating Scale (MADRS) and the Brief Psychiatric Rating Scale (BPRS) assessed BD symptoms. A total of 83 participants with BD and HTN were included. Adherence to BD and antihypertensive medications were positively correlated. eCAP openings showed more missed doses than self-reported antihypertensive adherence. BD medication adherence was positively correlated with BPRS at baseline; antihypertensive adherence was negatively correlated with SBP at screening. Antihypertensive adherence improved and SBP decreased between screening and baseline. Adherence levels fluctuated over time and differed based on measurement method in people with comorbid BD and HTN. Self-reported BD adherence was positively related to global psychiatric symptoms and antihypertensive adherence was related to better SBP control. Monitoring both medication and blood pressure led to change in self-reported adherence. BD symptom severity may indicate poor adherence in patients with BD and should be considered in treatment planning.

Investigating the Effect of COVID-19 on Pregnancy-Induced Hypertension (HTN): A Case-Control Study.

Suppression of the body's immune system can cause high blood pressure. Also, many people with COVID-19 have underlying diseases, including high blood pressure. This study was conducted to investigate the effect of COVID-19 infection on blood pressure caused by pregnancy in women referred to Kashani Hospital in Jiroft City. This study was a case-control study with a census sampling method on 266 pregnant women referring to Kashani Hospital in Jiroft City in 2021-2022. Pregnant women were divided into two control groups (pregnant women without COVID-19) and intervention (pregnant women with COVID-19). SPSS software version 22 was analyzed. 266 pregnant women participating in the study were divided into two equal control (133) and intervention (133) groups. The average age of pregnant women was 29 ± 6.8 years. The average systolic and diastolic blood pressure in the intervention group was 112.6 and 70, and in the control group, it was 107.8 and 66.6, which was not statistically significant (P_Value>0.05). Also, the results showed that there was a difference between home blood pressure during pregnancy and there is a statistically significant relationship between the age of pregnant women (P_Value< 0.05).. while there is no significant statistical relationship between gestational age and body mass index (P_Value>0.05). According to the results of this study, COVID-19 affects blood pressure caused by pregnancy, and gestational age is an important factor in the prevalence of high blood pressure in women with COVID-19.

Simulated analysis and experimental validation of sound field distribution regularity for a large-scale non-anechoic harbor pool

The large-scale underwater space, such as large water pool or large-scale harbor pool can provide a good experimental environment for the measurement of the underwater radiated noise of vessel. However, it's not as simple as measuring the sound power of a small machine in the air, the measurement and evaluation of the low frequency mechanical noise and radiated sound power of vessel requires a specific reverberation environment in the large-scale underwater space. Therefore, in this paper, the reverberant sound field characteristics of large-scale underwater space are simulated and calculated by finite element analysis, and experimental measurements are carried out in the large-scale harbor pool. It was found the cut-off frequency of large-scale underwater space depends on the depth of the water pool, and the lower limit frequency depends on the volume of the water pool. The dock door does not reduce the spatial average sound pressure in the reverberation sound field, the floating box platform does not effect on the cut-off frequency but has an effect on the sound energy of the reverberant sound field. It is possible to select the appropriate underwater experimental environment for the measurement and evaluation of different mechanical noise sources. The sound pressure level obtained by calculating the sound source at different locations in the reverberation area is basically the same, and in a 16 × 22 hydrophone arrays, more than 160 array elements are selected, each between 0.25 m and 1 m, a stable sound pressure level can be obtained through spatial averaging. Through experimental measurement verification in the large-scale harbor pool, low-frequency sound sources are emitted from 6 different positions, three hydrophone arrays data are collected, and the measured sound pressure level error is within 1.4 dB. These conclusions are conducive to the actual measurement and evaluation of noise sources of vessel.

On atmospheric pressure and temperature correlation across various terrain types

Temperature (T), pressure (p), and density (ρ) are fundamental variables describing the atmospheric behavior. This study investigates the interdependence of these variables near Earth's surface in real-world conditions, by evaluating data from different European weather stations. It has been found that the correlation between pressure and temperature is strongly related to the dynamics of the PBL that facilitates a two-group classification. The first group includes all the stations in the plain or in the valley-floor and exhibits a weak correlation, R(p,T). 2D density plots representing hourly pressure against temperature have a distinctive triangular shape at these stations. Regardless of location, the upper boundary of this triangle consistently fits a linear equation with a constant slope and an intercept that scales with the average pressure of the station. This finding holds promising implications for enhancing the quality check of pressure and temperature data, enabling the identification of implausible measurements using a unified equation. In contrast, the second group includes stations with a strongly positive correlation R(p,T) and a more linear density plot; it includes all stations near a mountain-top. Their correlations exhibit identical features when compared to radiosounding data extracted at corresponding heights. The study concludes that: i) the first group of stations is significantly influenced by non-hydrostatic processes such as turbulence, friction and surface radiative heating/cooling in the PBL, resulting in weakly negative R(p,T) for shorter timescales that become null over longer durations; ii) the second group of stations has R(p,T) characteristics similar to the free atmosphere, predominantly regulated by hydrostatic balance and the advection of sensible heat.

Bilateral superselective adrenal artery embolization for bilateral primary aldosteronism: a novel approach in an efficacy and safety proof-of-principle trial.

Superselective adrenal artery embolization (SAAE) offers a novel approach for treating primary aldosteronism (PA). In this study, we aimed to assess the efficacy and safety of SAAE for the treatment of PA based on the lateralization results obtained from adrenal vein sampling (AVS).In this prospective study, we enrolled 40 patients with PA who underwent SAAE. The patients were categorized into two groups, unilateral PA and bilateral PA, based on AVS results. Clinical parameters and biochemical markers were assessed at 3 and 12 months postoperatively. The primary outcomes were changes in blood pressure and defined daily dose (DDD) of antihypertensive medications compared to baseline. Thirty-eight patients achieved technical success, with favorable clinical and biochemical efficacy rates. At three months postoperatively, the clinical efficacy rates were 79.2% and 78.6% for the UPA and BPA groups, respectively. At 12 months, the rates were 83.3% and 71.4%, respectively. Both groups exhibited a significant decrease in average blood pressure at 3 and 12 months compared with baseline (P < 0.001), and there was also a notable reduction in DDD (P < 0.05). At three months, the biochemical efficacy rates were 61.9% and 58.3% in the UPA and BPA groups, respectively. Due to loss to follow-up, biochemical indicators were not assessed at 12 months postoperatively. No severe adverse reactions occurred during or after SAAE. Patients with both UPA and BPA can benefit from SAAE. The superiority of bilateral adrenal artery embolization in the treatment of BPA over unilateral adrenal artery embolization requires further investigation.

Elevated systemic venous pressures as a possible pathology in prepubertal pediatric idiopathic intracranial hypertension.

Pediatric idiopathic intracranial hypertension (IIH) is a rare and challenging condition. As implied by the nomenclature, the etiologies remain unknown, and multiple etiologies are being investigated. In this study, we explored the potential role of increased systemic or cerebral venous pressure in the pathogenesis. An observational cohort study following the STROBE guidelines, including prepubertal children with clinical symptoms and imaging findings consistent with IIH referred to the neurosurgical department, was conducted. The patients underwent a comprehensive diagnostic protocol, including MRI, continuous intracranial pressure (ICP) monitoring, and endovascular venography with venous pressure measurements. The study included 11 consecutive patients (six boys and five girls) with an average age of 2.3years, and an average BMI of 18.4. Among these, one patient was found to have venous stenosis with a gradient; the other 10 patients presented with normal intracranial anatomy. All patients exhibited elevated venous pressures, with an average superior sagittal sinus pressure of 18.9mmHg, average internal jugular vein pressure of 17.0mmHg, and average central venous pressure of 15.9mmHg. Daytime ICP averaged 12.9mmHg, whereas nighttime ICP averaged 17.2mmHg with either A- or B-waves in 10 of the 11 patients. Despite pathological ICP, only three patients had papilledema. All patients had an increased systemic venous pressure, indicating a possible pathological factor for prepubertal IIH. Additionally, our findings show that young children often only partly meet the Friedman criteria due to a lack of papilledema, emphasizing the need for pediatric-specific diagnostic criteria. Further large-scale studies are needed to confirm these findings and to explore the underlying reasons for this increase in venous pressure and potential new treatment avenues.

The performance of a spark ignition gasoline engine with hydrogen addition under low-load conditions

With continuously increasing populations and industrialization, more and more green consumers and stringent emission regulations promote low-carbon or zero-carbon alternative fuels in transportation sector. Hydrogen is considered carbon-free when produced using environmentally friendly methods, and could achieve zero carbon emission in the internal combustion engines. This study comprehensively explores the influences of the hydrogen addition on the performance of the gasoline spark ignition (SI) engine operated at low-load conditions. The experimental results showed that the abnormal combustion cycles of the test gasoline engine are greatly reduced with hydrogen enrichment. In addition, the coefficient of variation (COV) of the indicated mean effective pressure (IMEP) of the gasoline engine is 2.66 % under the 1500 rpm and 0.2 Mpa (brake mean effective pressure: BMEP) condition, while the COV of IMEP of the engine fuelled with gasoline and hydrogen is 2.34 % at the same condition. Furthermore, the knocking intensity of the gasoline engine is strengthened by adding hydrogen because the averaged maximum pressure rise rate (MPRR) of the gasoline SI engine is slightly increased. Besides, the indicated thermal efficiency (ITE) of the gasoline engine is increased 0.9 % and its maximum increase rate of the ITE is 4.27 % with hydrogen addition at the 1300 rpm and 0.2 MPa condition. Last, unburned HC, CO, and CO2 of the gasoline engine are reduced while NOx emissions increase with adding hydrogen due to high combustion temperature.

Numerical study on heat transfer and pressure performance of different suspension nozzles

The drying process of the lithium battery pole pieces makes extensive use of the suspension nozzle. It is of great significance to study the heat transfer and pressure steady-state characteristics of the suspension nozzle and to select the appropriate nozzle structure for the production of pole pieces. Based on the SSTk-ω\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${\ ext{SST }}k - \\omega$$\\end{document} turbulence model, this article numerically simulates the impact jet process of suspension nozzles with slits, injection holes, and effusion holes. There is a qualitative and quantitative analysis of the distribution of their velocity field, temperature field, local Nusselt number, average Nusselt number, local pressure coefficient, and average pressure coefficient, and the comprehensive performance index of the nozzle is proposed. The results show that when the weight factor of heat transfer performance α is less than 21.61% and the weight factor of pressure performance β is more than 78.39%, the comprehensive performance of the traditional suspension nozzle with double slits is the best. As the α is increasing, the β is decreasing. The comprehensive performance of the suspension nozzle with effusion holes is the best. The turbulent intermittence, interaction between neighbouring jets, and edge effects affect the heat transfer and pressure uniformity of the suspension nozzle.