The position of mechanical arm in people’s life is getting higher and higher. It replaces the function of human arm, moving and moving in space. Generally, the structure is composed of mechanical body, controller, servo mechanism, and sensor, and some specified actions are set to complete according to the actual production requirements. The manipulator has flexible operation, good stability, and high safety, so it is widely used in industrial automation production line. With the development of science and technology, many practical production requirements for the function of the manipulator are more and more refined, especially in the high-end research field. For example, medical devices, automobile manufacturing, deep-sea submarines, and space station maintenance put forward higher requirements for it. In terms of miniaturization and precision, it can meet the needs of scientific research and actual production. But these are inseparable from the motion control system technology. This paper mainly introduces the research of manipulator control system based on AI wearable acceleration sensor, aiming to provide some ideas and directions for the research of wearable manipulator. This paper presents the research method of manipulator control system based on AI wearable acceleration sensor, including the establishment of manipulator kinematics model, common filtering algorithm, and PI algorithm of speed control system. It is used for the research and experiment of manipulator control system based on AI wearable acceleration sensor. The experimental results show that the average matching rate of the manipulator control system based on AI wearable acceleration sensor is as high as 88.89%, and the stability of the feature descriptor is high.