Objective: The article analyzes the impact of various factors on the profitability of small and medium-sized enterprises (SMEs) in Vietnam amidst an economic crisis, using a dataset of Vietnamese SMEs from 2016 to 2018 across different provinces nationwide. Method: Employing panel data regression techniques in two forms: Fixed Effects (FE) and Random Effects (RE) models to estimate the impact of factors on enterprise profitability. Results and Discussion: Through estimating the two models on the article's dataset, the RE model shows that the coefficients of the explanatory variables in the model are statistically significant, whereas the FE model's coefficients are not. The estimation results from the RE model indicate that all variables including equity value, number of foreign workers, number of sectors the enterprise operates in the dummy variable for state support, average labour cost, and the dummy variable for the main operating sector of the enterprise affect the profitability of the enterprise. The RE model results suggest that the most significant factors impacting enterprise profitability are the business sector and state support. We need to have policies that create favorable conditions for businesses to achieve sustainable development goals (SDG). Conclusions: Results from the estimated model show that the most important factors affecting business profits are the business sector and state support. The state and businesses need to take measures to innovate activities to help businesses develop sustainably during the economic crisis.
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