The mixed control chart is proposed to improve detection performance with fewer process shifts. In this study, we proposed the modified exponentially weighted moving average - moving average control chart (MMEM), a new mixed control chart for observing the changes in the process mean. Average run length, standard deviation of run length, and median run length can be used to examine the effectiveness of detecting changes in the proposed chart with Shewhart, Moving Average (MA), Modified Exponentially Weighted Moving Average (MEWMA), and Mixed Moving Average - Modified Exponentially Weighted Moving Average (MMME) control charts in parametric and nonparametric distributions that use Monte Carlo simulation. The results demonstrate that the proposed chart outperforms other control charts mostly in the detection of small-to-moderate shifts. To illustrate the application of the proposed chart, chemical process temperature data and dataset on survival times of a group of patients suffering from head and neck cancer disease and treated with radiotherapy were provided, and it was discovered that the proposed chart performs better than other control charts.