Downward condensation of a near-azeotropic low GWP refrigerant mixture of R290/R1270 (65%/35% wt.), named HC01, was investigated inside an offset strip-fin (OSF) flow-structured plate heat exchanger (PHE). This study tested the prototype heat exchanger with HC01 and compared the condensation heat transfer coefficient (CHTC) and pressure drop (CPD) with the pure R-290 for working conditions of refrigerant mass flux (G) = 20–50 kg/m2s, inlet vapor quality (xin) = 0.2–0.9, saturation temperature (Tsat) = 40–55 °C, and heat flux (q) = 4–13 kW/m2. It was observed that the condensation of HC01 occurred entirely within the forced convection condensation flow regime, despite a slight change in the CHTC at a lower xin as the G increased. The CHTC demonstrated an increase in response to higher values of G and q, but decreased with increasing Tsat. Similarly, the CPD exhibited an increase with higher G and a decrease with lower Tsat, whereas the q had minimal influence. Comparison results showed that the HC01 exhibited 14.2% higher average CHTC but 6.5% lower CPD than that of R-290 because of the differences in properties, such as liquid thermal conductivity, viscosity, surface tension, latent heat, and discrepancies in liquid and vapor phase densities. Correlations were generated to predict the values of the Nusselt number (Nu) and friction factor (FF) of HC01, with mean absolute errors of 12.1% and 12.7%, respectively.