How to predict and study persistent extreme precipitation events (PEPEs) with a prediction period of 1–2 weeks is an important scientific problem faced by the meteorological circles at home and abroad. Based on the accurate description of the flood range caused by 14-day PEPEs, the comprehensive analysis method was used to obtain the weather characteristics related to 14-day PEPEs (including abnormal trough/ridge, westerly jet, atmospheric river (AR) activity, teleconnections, etc.). First, we selected three regions in China, North China (NC), the Yangtze River valley (YRV), and South China (SC), analyzed their 14-day PEPEs in summer (June to August), and composited them into an average circulation (500 hPa geopotential height field) to compare the weather patterns related to PEPEs in these regions. Then, several variables are composited to understand the evolution of the atmospheric state before and during the occurrence of PEPEs. Finally, potential applications of several teleconnection types and composites in advance prediction are studied. The main findings include: the common weather signals during the occurrence of PEPEs are characterized by obvious and continuous a high-low-high saddle field circulation configuration (conducive to the formation of frequent heavy rainfall), active westerly jet (westerly jet is the controlling factor of precipitation), and enhanced water vapor transport (significantly increased atmospheric river activity). In this study, some key characteristics and development of PEPEs were identified, the formation mechanism of China’s 14-day PEPEs was revealed, the role of ARs in PEPEs was recognized, and the PEPEs precursor signal was extracted. Furthermore, PEPEs in different regions were also compared, which played an important role in understanding and predicting similar events.