Abera Kumie , Kalkidan Genete, Helina Worku, Eshetu Kebede , Frehun Ayele , Habtamu Mulugeta Abstract Background: The magnitude of the sanitary conditions of food and drink establishments in urban centres of Ethiopia is very limited and unknown in most cases. Objective: To assess, the sanitary-hygienic conditions of public catering establishments in the district town of Zeway, Southern Ethiopia. Methods: A cross sectional descriptive study was conducted in all existing food and drink establishments. Results: Local informal catering establishments is considerably high in town with the ratio of about 1:1 to that of formal sectors. A piped water supply was found in all establishments. About 59% of the establishments had some kind of human waste management means, dry pit latrine being the commonest. Liquid waste and refuse management were found to be grossly inadequate in 73.5% and 81% of establishments, respectively. Some kind of acceptable type of clients' hand washing, soiled dish and glass washing facilities were found in 29.9%, 66.6%, and 72.8% of establishments, respectively. Food handlers in 14.8% of establishments had some form of active skin and respiratory infections. The personal hygiene of food handlers in most establishments was very poor and that only 21.65% of them had acceptable type of over coats used while working. Glass washing facilities, latrine availability, and water source type are strongly associated with the presence of licence, OR=10.62 (3.66,37.09), OR=23.80 (8.72,67.8), OR=183.42 (37.78,1632.28), respectively. Conclusion and Recommendation: The poor sanitary conditions of food and drink establishments favours the transmission of food borne communicable diseases. A public intervention towards the improvement of the establishments is highly recommended. [Ethiop. J. Health Dev. 2002;16(1):95-104]