ObjectiveRecent years have seen increased cases of measles despite widespread vaccination. We examine potential drivers behind the resurgence of measles. MethodsWe analyze the trends in measles incidence and vaccine coverage from 2010 to 2019 across World Health Organization (WHO) member countries using country-level linear regression models. We compute Spearman's rank correlation coefficient (ρ) between measles incidence and socioeconomic and vaccination-related variables using published data from the WHO member countries to identify key factors influencing measles incidence. ResultsBetween 2010 and 2019, global measles cases fluctuated with a notable rise in 2019 (measles cases per million in 2019 was about 140% higher than in 2010), alongside a declining vaccination coverage in many countries (59 out of 194 countries). Among 10 socioeconomic factors examined, per-capita national gross income, population literacy, urban residences, and political stability were significantly associated with measles incidence (ρ < 0, and P-value <0.05 for all these variables). These factors likely reflect the quality of public health infrastructure (e.g., access to vaccines), particularly in low- and middle-income countries (LMIC). In addition, stratified analysis suggests vaccine hesitancy likely contributed to measles case increases in high- and upper-middle income countries (HIC & UMIC). ConclusionThe socioeconomic determinants of measles transmission are interconnected and region-specific. Availability of public health resources and political stability significantly influence measles burdens in LMIC, while vaccine hesitancy presents a unique challenge to measles elimination in HIC and UMIC.