Cholera has been around for centuries but in our modern history there has been a resurgence with at least 7 devastating global outbreaks occurring worldwide in in the last century each claiming thousands of innocent lives. Cholera infects 1.3 to 4 million people around the world, killing 21,000 to 143,000 people annually according to the World Health Organization (WHO). It is thus imperative to research this bacterial disease and come up with ways of shedding light on effective prevention and cure. Cholera is an illness of multi-causal origin where biological, environmental, social, political, and cultural factors intervene. This disease continues to resurge as a sanitary problem of great magnitude in many countries and emerged in Haiti following the January 12, 2010 magnitude 7.0 earthquake some 16 miles from the capital city of Port-au-Prince, where it caused massive damage to roads, buildings, and the environment. Although Haiti is among the poorest countries in the Americas, and its capital city lacked much in the way of modern public sanitation at the time of the earthquake, the country had been cholera free for at least 150 years or more at the time of the earthquake. By mid-October 2010, the first cases of cholera began to appear, and by the end of the decade would infect some 800,000 Haitians (~10% of the population of Haiti) and approximately 10,000 deaths. The source of the infection was traced to the Artibonite River, a main source of water in Haiti, which was believed to have become unknowingly contaminated by well-intentioned foreign workers from Nepal following the earthquake. The strain of cholera found in Haiti was similar to the one found in Nepal (CDC). Haiti employed measures of Cholera prevention and eradication efforts including water treatment, sanitation and hygiene measures, education, oral vaccination, and addressing climate variability issues, history, epidemiology, clinical diagnosis, and treatment, monitoring and prevention of this disease to prevent further loss of life. By 2020, no new cases of cholera have been reported for over 12 months, indicating that Haiti may soon be cholera free once again. Results/Conclusion: Effective hygienic conditions, timely medical intervention including supportive care, access to the appropriate antibiotics, availability of clean drinking water, hand washing, and other prevention protocols can help curb the loss of life associated with cholera. Cholera can kill a healthy person within 12 to 24 hours from the onset of diarrhea, as it is quite virulent. The current situation of cholera in the world (particularly in Haiti), and the extensive collaborative relation and the geographical proximity to Haiti makes the epidemiological risk in neighboring countries increase; therefore, immediate action is required in the organization of health services to prevent yet another epidemic.