Brucellosis is one of the major public health problems in China, and human brucellosis represents a serious public health concern in Xinjiang and requires a prediction analysis to help making early planning and putting forward science preventive and control countermeasures. According to the characteristics of the time series of monthly reported cases of human brucellosis in Xinjiang from January 2008 to June 2020, we used seasonal autoregressive integrated moving average (SARIMA) method and nonlinear autoregressive regression neural network (NARNN) method, which are widely prevalent and have high prediction accuracy, to construct prediction models and make prediction analysis. Finally, we established the SARIMA((1,4,5,7),0,0)(0,1,2)12 model and the NARNN model with a time lag of 5 and a hidden layer neuron of 10. Both models have high fitting performance. After comparing the accuracies of two established models, we found that the SARIMA((1,4,5,7),0,0)(0,1,2)12 model was better than the NARNN model. We used the SARIMA((1,4,5,7),0,0)(0,1,2)12 model to predict the number of monthly reported cases of human brucellosis in Xinjiang from July 2020 to December 2021, and the results showed that the fluctuation of the time series from July 2020 to December 2021 was similar to that of the last year and a half while maintaining the current prevention and control ability. The methodology applied here and its prediction values of this study could be useful to give a scientific reference for prevention and control human brucellosis.