Autonomic Nervous System In Children Research Articles

Features of vegetative adaptation to educational activities of primary school children

Purpose. To study the functional state of the autonomic nervous system (ANS), which is involved in the formation of adaptation processes in schoolchildren with different physiological abilities. Material and methods. Three groups of junior schoolchildren were examined: 1st – intellectually gifted children, selected based on the results of specialized scales and tests; 2nd – children with high sports/physical abilities; 3rd (control) – schoolchildren with good academic performance and sports/physical abilities. The functional state of the ANS of children was studied using cardiointervalography. Results. The dynamics of the mode indicators, mode amplitude, variation range, and tension index of regulatory systems (IN) indicated that in group 1 the activity of the sympathetic influences of the ANS predominated, the ratio IN2/IN1 showed hypersympathicotonic reactivity. In group 2, the IN values corresponded to normotonic values. The majority of children in groups 2 and 3 had a normal type of autonomic response. The greatest increase in heart rate and systolic blood pressure during orthostasis was observed in group 1. Conclusion. Multidirectional changes in systolic blood pressure and an increase in diastolic blood pressure of varying degrees of severity were established in children of the study groups, which indicates the heterogeneous nature of vascular reactions to orthostasis. The rhythmogram indicators in group 1 are characterized by the predominance of the activity of the sympathetic influences of the ANS. The identified imbalance in the functional activity of the ANS in children of the 1st group indicates the tension of adaptation processes.

Reactivity of the autonomic nervous system in children of younger school age with mental retardation

Introduction. The functioning of the autonomic nervous system (ANS) to some extent affects various aspects of human health and general well-being. One of the main ANS functions is to ensure adaptation to the factors of the external and internal environment, carried out by the coordinated activity of the sympathetic and parasympathetic links. Determining the predominant type of ANS reactivity according to the characteristics of the heart rhythm makes it possible to predict the adaptive capabilities of the child’s body in the learning process in a personalized way. 
 The aim of the study was to study the trend in heart rate variability in children with special health conditions associated with disorders of the intellectual development, which characterizes the implementation of mechanisms for adapting the body to the conditions of schooling.
 Materials and methods. We examined one hundred sixty eight 7–11 years children of primary school age, including 54 children with special health abilities (SHA) (F70, F71), and 114 mentally healthy children. The study of heart rate variability was carried out using the hardware-software complex “ORTO Valeo”. There was analyzed TP, HF, LF, VLF, LF / HF; RMSSD, SDNN, Mo, AMo, ΔX, IN, AMo / Mo, Amo / ΔX; type of vegetative regulation.
 Results. In SHA children of primary school age, the LF, VLF, LF / HF indices are increased and HF is decreased relative to the control group, which indicates the predominance of the sympathetic link of the autonomic nervous system over the parasympathetic. When analyzing the spectral components in SHA children of primary school age, VLF (40.6%) and low HF (19.6%) dominate. According to the types of autonomic regulation in SHA children, the following ratio was found 50: 4: 33: 13, the central type of cardiac regulation dominates (type I).
 Limitations. The limitation of the study is due to the specifics of the individuals in the observation group – children of primary school age (7–11 years) with special health opportunities associated with mental retardation.
 Conclusion. SHA children of primary school age have high activity of sympathetic modulation, reduced resistance to stress, high tension of adaptive responses with the dominance of the central type of regulation of the cardiac activity. The revealed imbalance of the parameters of autonomic regulation in SHA children without corrective measures (including correction of physical status, psychoemotional and educational loads) threatens the development of a breakdown of adaptive responses to the effects of various internal and external factors, contributing to asthenization of regulatory systems.

Effects of Mitral Valve Prolapse on Heart Rate Variability and the Autonomic Nervous System in Children.

Patients with mitral valve prolapse (MVP) may reveal symptoms of autonomic dysfunction and heart rate variability (HRV). We sought to explore the autonomic nervous system in children with MVP. This cross-sectional study enrolled 60 children aged between 5 and 15 years with MVP and 60 age- and sex-matched healthy children as controls. Two cardiologists performed electrocardiography and standard echocardiography. HRV parameters were explored via 24-hour rhythm 3-channel Holter monitoring. The depolarization of ventricular and atrial parameters, comprising QT max and min, QTc intervals, QT dispersion, P maximum and minimum, and P-wave dispersion, was measured and compared. The mean age was 13.12±1.50 years in the MVP group (F/M: 34/26) and 13.20±1.81 years in the control group (F/M: 35/25). The maximum duration and P-wave dispersion in the MVP group were significantly different from the healthy children (P<0.001). The longest and shortest QT dispersion values and QTc values were significantly different between the 2 groups (P=0.004, P=0.043, P<0.001, and P<0.001, respectively). The HRV parameters were significantly different between the 2 groups, too. Decreased HRV and inhomogeneous depolarization showed that our children with MVP were prone to atrial and ventricular arrhythmias. Furthermore, P-wave dispersion and QTc could be used as prognostic markers of cardiac autonomic dysfunction before it is diagnosed by 24-hour Holter monitoring.

Correction of vegetative disorders in children with irritable bowel syndrome

Introduction. The article considers the formation of irritable bowel syndrome (IBS) in children. In recent years this pathology occurs more often among the adult and children population in many countries in the world. According to the modern view of the problem, this disease is considered a biopsychological disease, in the development of which an important role is played by the connection of psychological factors, dysfunctions of the autonomic nervous system, motor and secretory disorders of various parts of the intestine, which can cause the discomfort, changes of intestinal habits. All these factors lead to a decrease in the quality of life in children. Purpose of research. The main goal of this research is to study the peculiarities of the status of the autonomic nervous system in children with irritable bowel syndrome and to evaluate the effectiveness of the proposed therapy. Materials and methods One of the main methods for assessing the condition of the autonomic system in patients is cardiointervalography. During this examination, we calculated the index of tension, which is one of the main indicators of assessing the condition of this part of the nervous system. According to this index’s indicators, the vegetative system’s state can be divided into three main variants of functioning – vagotony, eutony, and sympathicotony. All patients were divided into groups according to the main complaints and course of IBS – IBS with constipation (IBS -C), IBS with diarrhea (IBS- D), a mixed form of IBS and an unclassified form of IBS. And also another two large groups were formed – main and control. Results. We analyzed the cardiointervalogram indicators in both groups of patients with different clinical variants of IBS. In the main group, we registered a statistically significant decrease in the index of tension and an improvement in autonomic nervous system dysfunction in patients with IBS with constipation and diarrhea. Indicators in these groups were changed from the state of vagotony and sympathicotonia to eutony. This indicates the restoration of the function of the normal function of the autonomic nervous system. Patients from the control group also showed changes in the index of tension, but the indicators stayed in the borders of vagotony and sympathicotony, and didn’t reach the level of eutony. Conclusions. Аfter the evaluation of the received data, it was proved that the use of hopanthenic acid in the complex therapy of irritable bowel syndrome effectively improve the status of the autonomic nervous system in children.

РЕАБИЛИТАЦИЯ ДЕТЕЙ И ПОДРОСТКОВ С ЛОКАЛЬНЫМИ ФОРМАМИ ТУБЕРКУЛЕЗА ЛЕГКИХ НА ГОСПИТАЛЬНОМ ЭТАПЕ

A prospective study was conducted to investigate the effect of therapeutic physical exercise in combination with low-frequency pulsed sound on the functional state and energy supply of the autonomic nervous system in children with local forms of pulmonary TB during inpatient treatment. The study enrolled 16 children aged 4–16 years. Seven were diagnosed with intrathoracic lymph node TB, seven – primary tuberculous complex, and two – infiltrative TB. All the patients received treatment according to the clinical recommendations. In addition, they performed breathing exercise under the instructor’s control for a month. Weak acoustic impulse signals were added to the musical accompaniment. The amplitude and the frequency of stimuli was adjusted for adequate perception by the vibration receptors. Heart rate variability and skin bioelectrical activity were monitored before the course of exercise and four weeks after its completion. It was established that the skin conductance and the frequency of spontaneous reactions decreased, which was a sign of good energy supply of the nervous system. Physical exercise did not provoke adverse cardiac or nervous reactions in children with active pulmonary TB.

The state of response of autonomic nervous system in children with mitral valve prolapse

The article presents summarized materials on connective tissue dysplasia of the heart, primary mitral valve prolapse, dysfunction of the autonomic system. Aim of research: to estimate the condition of autonomic nervous system in children with primary mitral valve prolapse. We examined 106 children with mitral valve prolapse aged from 13 to 17 years old on the clinical base of city hospital “Center of mother and child” in Vinnitsya. Research included time and frequency domain (evaluation with cardiointervalography. Final results were compared with the control group records. The results showed no statistical significance among time domain parameters in the main group of children. All these indices displayed tendency to sympathetic and parasympathetic autonomic nervous system tonus increase in boys. However, sympathicotonia tendency was noted in girls only. Frequency domain parameters showed similar results, compared with the previous. Nevertheless, very low frequency parameters had statistically significant difference in both subgroups of patience with mitral valve prolapse, including males (3205.8±190.9 against 1717±154, р&lt;0.05) and females (3280±220.1 against 1433±811, р&lt;0.05). There were no statistically significant difference among other frequency domain parameters. Conclusions: we estimated that children with mitral valve prolapse have imbalanced autonomic homeostasis manifested by tone disturbances of both autonomic vegetative system branches with sympathetic predominance. Patients with primary mitral valve prolapse generally have increased sympathetic tone - both boys and girls - according to spectral analysis of heart rate variability indices, heart rate oscillation power of a very low frequency in particular (p&lt;0.05). In children with mitral valve prolapse, the tone of parasympathetic nervous system is generally normal; there is a tendency to its increase in boys and decrease in girls. These children should be under close medical supervision by pediatricians and cardiologists.

The clinical significance of the parameters of the capillary bed, heart rate variability, and computer bronchophonography in the differential diagnosis of diseases accompanied by prolonged cough in children

Differentia! diagnosis of the causes of prolonged cough is difficult because of its multifactorial nature. Diagnostics in case of a cough that persists for more than 4 weeks is based on clinical data, but sometimes it is not enough to establish a diagnosis. This issue led to the development of algorithms based on additional diagnostic criteria evaluated with modern non-invasive functional methods for diagnosing diseases accompanied by a prolonged cough in children.Aim. To determine the differential diagnostic value of the functional parameters of the capillary bed, respiratory tract, and autonomic nervous system in children with diseases accompanied by a prolonged cough (more than 4 weeks).Methods. 238 children aged from 2 to 17 years with prolonged cough were examined in inpatient or outpatient settings and divided into 4 groups: Group 1 (n = 68) - patients with acute or exacerbation of the chronic infectious upper respiratory tract diseases; Group 2 (n = 53) - patients with lower respiratory tract infection; Group 3 (n = 39) - patients with allergic rhinitis; Group 4 (n = 78) - patients with bronchial asthma. All patients underwent standard clinical examination. The diagnostic test also included functional assessment of microcirculation, autonomic nervous system, and respiratory system via computer capillaroscopy of the nail bed, evaluation of heart rate variability, and computer bronchophonography.Results. Patients with allergic diseases of the respiratory tract, especially with asthma, show a change in all parts of the capillary bed and a significant increase in the zone of perivascular edema in combination with parasympathicotonia, in contrast to children with infectious diseases of the respiratory system, who showed a change in microcirculation parameters mainly in the venous capillaries in combination with sympathicotonia. In addition, children with prolonged coughing, regardless of its origin, showed functional changes in the high-frequency acoustic parameters of the respiratory system in the form of an increase in the coefficient of the high-frequency acoustic component of breathing (ф3), which indicates bronchial hyperreactivity.Conclusion. The functional parameters of the microvasculature, autonomic nervous system, and respiratory tract can be used as additional differential diagnostic criteria and included in algorithms for diagnosing respiratory diseases of various origins in childhood, contributing to the early detection of the pathology and timely targeted therapy.

Evaluation of autonomic nervous system in children with spastic cerebral palsy: clinical and electophysiological study

BackgroundCerebral palsy (CP) is the most prevalent severe motor disability among children. The aim of this work was to assess autonomic dysfunction in children with cerebral palsy clinically and electrophysiologically.ResultsAge of the studied children ranged from 4 to 12 years. Quadriplegic type of spastic cerebral palsy constituted 82.5% of CP children while diplegic type constituted 17.5%. Based on Gross Motor Function Classification System (GMFCS), the majority of children were in levels 4 and 5. The prevalence of autonomic dysfunction symptoms were 80% for thermoregulatory abnormalities (cold extremities), 65% for chronic constipation, 52.5% for sleep disturbance, 47.5% for loss of appetite, 40% for sweating abnormalities, 25% for recurrent nausea and/or vomiting, 22.5% for increased sensitivity to light or dark and 15% for bloating. As regards sympathetic skin response, 19 CP children had unobtainable response in both upper and lower limbs while 5 children had unobtainable response in lower limbs only. All of them were in levels 4 and 5 of GMFCS. Postural hypotension was present in 20% of CP children. Mean Heart rate of CP children was significantly increased more than healthy children upon head tilt test.ConclusionsAutonomic dysfunction has been objectively proven in CP children through absent sympathetic skin response, presence of orthostatic tachycardia and postural hypotension.

Peculiarities of vegetative provision and disorders of tolerance to exercise in children with endocrine and cardiac pathology

Annotation. The aim – to find out the features of autonomic support and exercise tolerance of the cardiovascular system in children with chronic non-infectious diseases, in the future will be able to improve the results of diagnosis and rehabilitation of patients, as well as differentially regulate the mode of the exercise regime for patients. The study included 58 children aged 10-17 years, with cardiac and endocrine pathology: group 1 – 23 children with endocrine pathology (type 1 diabetes mellitus), group 2 – 23 children with cardiac pathology (AH stages I-II). The study included clinical examinations, anthropometry, a questionnaire of physical activity by MAOFA, ECG, ultrasound examination of the heart and Rufier's test were performed. Assessment of the state of the autonomic nervous system was carried out using the Kerdo index and COT. Statistical analysis was performed using s/n program SPSS 17 4a 180844250981. It was found that there is a tendency to outstrip the normative values and increased body weight indicators in the examined children with chronic pathology of the endocrine and cardiovascular systems. According to the Rufier test, it was found that in the group of children with diabetes mellitus, 69.5±9.6% of the examined had low results. Among children with hypertension, 30.7±10.4% of the test indicators were regarded as weak, and in 26.9±5.8% – unsatisfactory. The results of Rufier's test were significantly lower in children with endocrine pathology, both in comparison with the group of children with cardiac pathology (p&lt;0.05) and with the control group (p≤0.001). In 70.0±15.3% of cases, weak and unsatisfactory indicators of the Ruffier test were observed against the background of hyperdiastolic autonomic support. In physically nonactive adolescents, asympathicotonic and hyperdiastolic types of COT were observed. Thus, almost 70% of children with diabetes mellitus and 57% of children with arterial hypertension have reduced exercise tolerance. This is associated with hyperdiastolic autonomic support. Physical activity has a positive effect on the state of the autonomic nervous system in children with arterial hypertension and diabetes mellitus.

Diagnosis and management of an inappropriate sinus tachycardia in adolescence based upon a Holter ECG: A retrospective analysis of 479 patients.

Inappropriate sinus tachycardia (IST) is a common disease of the autonomic nervous system in children and adults. Diagnosis and treatment of IST in adolescents is not well defined. In this retrospective study, we tested our hypothesis regarding autonomic dysfunction in childhood by analyzing 24-h heart rate variability (HRV) in 479 children, with a mean age of 13.7 ± 2.1 years, who were referred to the outpatient clinic in the Pediatrics Department within the last 15 years. Seventy-four adolescents with a mean 24-h heart rate ≥ 95 bpm (our cut-off for an IST based upon 66 healthy controls) were deemed to have IST. We found the risk of IST to be high in adolescents with attention deficit disorder (OR = 3.5,p<0.001), pre-hypertension (OR = 2.5, p = 0.043) and hypertension (OR = 2.1,p = 0.02); insignificantly enhanced in children with short stature (OR = 1.9,p = 0.19), surgically-treated congenital heart disease (OR = 1.4,p = 0.51) and obesity without hypertension (OR = 1.4;p = 0.25); and negligible in adolescents with anorexia nervosa (OR = 0.3, p = 0.26) and constitutional thinness (OR = 0.9,p = 0.89). IST was associated with a significant decrease in global HRV and elevated blood pressures, indicating an enhanced cardiovascular risk. Methylphenidate did not increase 24-h heart rates, whereas omega-3 fatty acid supplementation significantly decreased elevated heart rates and increased HRV in adolescents with IST. In this retrospective analysis, 15.4% of adolescents suffered from IST with a 24-h heart rate ≥ 95 bpm, predominately due to attention deficit disorder and hypertension.

The Capacity of Examination of Сhildren by a Family Doctor, as a Factor in the Prevention of Sudden Cardiac Death

The objective: evaluate the prognostic value of the Ruffier test as an indicator of the functional reserve capabilities of the cardiovascular system in children and adolescents.Materials and methods. With a prevention purpose we examined children at the age of 13±3 years (21 boys), who train in the basketball section. All children underwent testing of the Ruffier breakdown and were assigned to the main group with an average Ruffier index of the group 3,0±0,2. At the time of the examination, everyone considered themselves healthy. Children underwent blood pressure measurements, ECG recording at rest, and ultrasound examination of the heart.Results. According to the results of an ECG study, one of the examined had single supraventricular extrasystoles. According to the results of blood pressure measurements in 3 patients (14,2%), hypertension was detected. Based on the results of ultrasound examination of the heart in children who were diagnosed with hypertension, concentric hypertrophy of the left ventricle was revealed. It should be emphasized that the autonomic nervous system in children and adolescents prone to functional imbalances, this does not allow us to reliably judge the functional reserve of the heart based on fluctuations in heart rate.Conclusions. The capacity of the preventive examination, which is now being performed by a pediatrician or family doctor, did not allow to reveal heart pathology of any origin. The Ruffier test did not add information to the survey. We consider it appropriate to include the following diagnostic tests in the required scope of the examination:1. Measurement of blood pressure.2. ECG recording at rest.3. Ultrasound examination of the heart.4. Evaluation of the level of TSH and free T4.5. The study of lipid metabolism.6. General blood and urine tests.

Assessment of Autonomic Nervous System in Children with Celiac Disease: A Heart Rate Variability Study

We evaluated the activity of autonomic nervous system in children with celiac disease by using heart rate variability (HRV) analysis. HRV parameters of 37 children with celiac disease were compared to 36 age- and sex-matched healthy controls. None of the participants had a systemic, central or peripheral neurological disease. Statistically significant differences were present in two parameters; standard deviation of all RR intervals (SDNN) and standard deviation of 5-minute RR interval means (SDANN). Age was negatively correlated with mean, minimum and maximum heart rate. Duration of disease was positively correlated with low frequency power-high frequency power ratio. No correlation was found between anti-tissue transglutaminase IgA level and HRV parameters. Celiac disease may affect autonomic nervous function in children even if there are no symptoms of dysautonomia.

RELATIONSHIP BETWEEN BODY WEIGHT AND LENGTH IN NEWBORNS AND INDICATORS OF AUTHONOMIC NERVOUS SYSTEM IN CHILDREN

The purpose of this work is to study the relationship between body weight and length in newborns and indicators of autonomic nervous system in children. To study the features of the autonomic regulation of heart rhythm, we studied children aged from four to seven years (125 boys and 114 girls). Five‐minute ECG were recorded during rest period. In four‐year‐old boys, we have found positive correlation between body weight at birth and SI («stress index») (r = −0.257, p &lt;0.05), AMo (r = −0.169, p &lt;0.05), heart rate (r = −0.002, p &lt;0.05). In girls of the same age, multiple regression analysis showed a pronounced effect of body weight at birth on SI (r = 0.506, p &lt;0.016) and AMo (r = 0.525, p &lt;0.01). In boys of five years old, a significant correlation was found between body weight at birth and the average value of RR intervals (r = 0.647, p &lt;0.001), Mo (r = 0.598, p &lt;0.001), AMo (r = −0.442, p &lt;0.01), SI (r = −0.465, p &lt;0,05), heart rate (r = −0.666, p &lt;0.001). For boys of five years old, significant correlation was observed between the length of the body of newborns and the average value of RR‐intervals (r = 0.583, p &lt;0.001), Mo (r = 0.518, p &lt;0.002), MxDMn (r = 0.441, p &lt;0.01), AMo (r = −0.539, p &lt;0.001), SI (r = −0.606, p &lt;0.001), heart rate (r = −0.600, p &lt;0.001). In girls of five years of age, a significant positive relationship was found between body weight at birth and SI (r = −0.173, p &lt;0.05), between the length of the body at birth and SI (r = −0.166, p &lt;0.05). The results of multiple regression analysis allow us to come to the conclusion about a more pronounced effect of body length at birth on indicators of autonomic nervous system in children. Body weight and body length of newborns may be use as cofactors when analyzing the influence of environmental factors on the functional state of the cardiovascular system.

Emotion Regulation via the Autonomic Nervous System in Children with Attention-Deficit/Hyperactivity Disorder (ADHD): Replication and Extension.

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent disorder characterized by symptoms of inattention, hyperactivity, and/or impulsivity, as well as executive dysfunction. Recent work underlines the importance in understanding the role of emotion reactivity and regulatory deficits in the context of the disorder. One study (i.e., Musser et al. 2011) utilized a positive and negative emotion induction and suppression task, as well as indexes of autonomic nervous system reactivity, to examine emotional functioning in youth with ADHD. This study revealed inflexible parasympathetic-based regulation across emotion conditions among youth with ADHD compared to typically developing youth. The present study sought to replicate and extend these findings to a clinically recruited, diverse sample, while also examining sympathetic functioning. Two hundred fifty-nine participants (160 youth with ADHD), aged 5 to 13, completed the task utilized in Musser et al. 2011, while indexes of parasympathetic (i.e., respiratory sinus arrhythmia [RSA]) and sympathetic (i.e., pre-ejection period [PEP] and electrodermal activity [EDA]) reactivity were obtained. ADHD was associated with significantly elevated parasympathetic (i.e., augmented RSA) and sympathetic (as indexed by EDA) reactivity. Overall, results replicate and extend Musser et al. 2011, revealing sympathetic-linked disruptions in emotion reactivity and parasympathetic-linked disruptions in emotion regulation among youth with ADHD. Future studies of behavioral therapies for ADHD should consider the efficacy of adding an emotion regulation skills training component.

The effects of antimuscarinic agents on the activity of the cardiac autonomic nervous system in children with functional overactive bladder

Functional overactive bladder disorder is one of the most prevalent presentations of bladder and bowel dysfunction in children, and it is associated with lower overall cardiac autonomic and parasympathetic activity. Antimuscarinics are the most frequently used pharmacological agents for treatment of children with functional overactive bladder disorder; however, there is a gap in the literature in describing the effect of antimuscarinics on the autonomic profile of this population. The aim of the study was to assess the cardiac parasympathetic activity before and after 12 weeks of oxybutynin treatment in children with overactive bladder. This was a single-institution prospective cohort study. Cardiac autonomic activity was assessed during storage and voiding phases of the bladder function via spectral analysis of heart rate variability and impedance cardiography. The primary outcome measure was high frequency, a proxy for parasympathetic nervous system activity. Parameters of uroflow study, severity of symptoms, and quality of life outcomes were also assessed. Ten children (7 females) diagnosed with overactive bladder with a median age of 10 years (range = 6-14) were followed up for a median treatment duration of 11.8 weeks (range = 6-19.4). After treatment, there was a significant reduction in high frequency during the storage phase (median change=-24.17%, p=0.047). No change was observed in the other outcome measures except for the overall Symptom Score for Dysfunctional Elimination Syndrome after treatment (5-point decrease, p=0.034) (Summary Table). The findings of the present follow-up study suggest that the use of oxybutynin in children with overactive bladder is associated with a significant reduction in the activity of the parasympathetic nervous system. The clinical implications of this finding are important because similar autonomic profiles (as markers of chronic stress) have been shown to be associated with increased inflammation and are found in major chronic diseases. The authors caution making a clinical connection between the heart rate variability profile of the patients in this study and patients with chronic diseases because oxybutynin is usually not administered as long-term treatment for overactive bladder. Use of oxybutynin was associated with reduction in cardiac parasympathetic activity of children with functional overactive bladder. Further investigation into the role of the autonomic nervous system as a treatment target in the management of these children is warranted.

Correction to: Emotion Regulation via the Autonomic Nervous System in Children with Attention-Deficit/Hyperactivity Disorder (ADHD).

This erratum reports an error in Musser, E. D., Backs, R. W., Schmitt, C. F., Ablow, J. C., Measelle, J. R., & Nigg, J. T. (2011). Emotion regulation via the autonomic nervous system in children with attention-deficit/hyperactivity disorder (ADHD).

TO THE QUESTION OF VEGETATIVE BACKGROUND IN CHILDREN WITH CHRONIC GASTRODUODENAL PATHOLOGY

Summary. It is proved that the vegetative dysfunction, which originated in childhood or adolescence, becomes an unfavorable background and a harbinger of many diseases, including chronic ones. In connection with the increase in the frequency of autonomic dysfunction in children, there is a need in recent years to study this problem. Objective. To study the state of the autonomic nervous system in children with chronic gastroduodenal pathology.Materials and methods. 120 school-age children were examined, who were hospitalized in the gastroenterological department of the city children's clinical hospital in Chernivtsi. Children are divided into two groups: the main one (60 people with chronic gastroduodenal pathology), and the control group (60 people with functional diseases of the gastrointestinal tract).During the questioning of children, using the questionnaire ofWayne, the state of the vegetative nervous system was evaluated. To determine the nature of autonomic dysfunction with a predominance of sympathetic or parasympathetic departments, the vegetative Kerdo index was used. All children were also electrocardiographically examined.Results. Children with chronic gastroduodenal pathology were twice as likely to have autonomic dysfunction as compared to the comparison group. Estimating the Curdo index in children from the main group, the prevalence of the sympathetic tone of the vegetative system was significantly higher (85.6 ± 0.2%, vs. 50.8 ± 0.3% in the control group and significantly less pronounced in them eutonia - 4.4 ± 0 4%, against 41.0 ± 0.2% in the control group, p &lt;0.05.Conclusions. The predominance of the frequency of autonomic dysfunction in children of the main group can be explained by the effect of autonomic dysregulation and organic lesions of the gastroduodenal zone in them.

Influence of the autonomic nervous system in children involved in badminton refraction

Influence of the autonomic nervous system in children involved in badminton refraction

Features of the autonomic nervous system in children with gastroesophageal reflux disease and different genotypes of C825t locus of Gnb3 gene

Захворюваність на гастроезофагеальну рефлюксну хворобу серед дітей неухильно зростає. Різноманітність клініко-морфологічних варіантів ГЕРХ зумовлює труднощі діагностики даної патології у дитячому віці. Враховуючи велику кількість етіологічних чинників, в тому числі порушення регуляції стравоходу з боку автономної нервової системи та генетичну схильність, необхідним є детальний аналіз кожного з них

O134 The dysfunction of autonomic nervous system in children with paroxysmal disorders

Introduction Autonomic nervous system (ANS) involvement in children with paroxysmal events can be seen at multiple levels, including epileptic ictal and postictal symptoms, status epilepticus, non-epileptic spells, side effects of antiepileptic drugs and vagus nerve stimulation. Autonomic testing combines a battery of tests serving to define the severity of the problem. Aim The aim of the study was to present current knowledge regarding the involvement of ANS in children with paroxysmal disorders. Material and methods Using key words ANS, epilepsy and syncope the search was performed in collections of Elsevier and Springer Journals, as well as PubMed. Results Manifestation of ANS dysfunctions may comprise a clinical spectrum of symptoms, including apnea, arrhythmia, hypotension and aspiration. Certain pediatric epilepsy syndromes present with a unique prominence of autonomic signs and symptoms (Panayiotopoulos syndrome). Autonomic dysfunction has been hypothesized in children with channelopathies such as Dravet syndrome. In adolescents with syncope, autonomic testing can help to stratify the risk of future episodes and to guide treatment decisions. Cardiovagal testing has been demonstrated in a number of paroxysmal disorders to be a marker of autonomic dysfunction. Conclusions Recognition of the diverse autonomic manifestations of epilepsy and non-epileptic spells would enhance early diagnosis and appropriate management, ultimately improving quality the of life of the affected patients. Symptoms of ANS dysregulation may warning as for life threatening conditions, so they should be included as a part of medical history and physical examination.